A Case of Metastatic Low-Grade Endometrial Stromal Sarcoma Treated with Letrozole after Ovarian Ablation by Radiotherapy
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
A 50-year-old woman was admitted to our hospital due to multiple lung nodulesdetected incidentally on a chest X-ray. A video-assisted thoracoscopic lung biopsyrevealed low-grade endometrial stromal sarcoma (LG-ESS). She had undergone asimple hysterectomy 1 year earlier owing to a diagnosis of adenomyosis. A review ofher previous hysterectomy specimen showed not endometriosis but LG-ESS. Accordingto the patient’s levels of serum follicle stimulating hormone and estradiol, shewas in the premenopausal state with retained and normally functioning ovaries. Shethen underwent ovarian ablation by radiotherapy, after which she was administered2.5 mg of letrozole once per day. Three months later, the size of the metastaticnodules in both lungs had decreased. The patient was followed up for 24 monthswhile continuing on letrozole, and maintained a partial remission. We report hereinon a case of metastatic LG-ESS treated with letrozole after ovarian ablation by radiotherapy.
Abstract
A 50-year-old woman was admitted to our hospital due to multiple lung nodulesdetected incidentally on a chest X-ray. A video-assisted thoracoscopic lung biopsyrevealed low-grade endometrial stromal sarcoma (LG-ESS). She had undergone asimple hysterectomy 1 year earlier owing to a diagnosis of adenomyosis. A review ofher previous hysterectomy specimen showed not endometriosis but LG-ESS. Accordingto the patient’s levels of serum follicle stimulating hormone and estradiol, shewas in the premenopausal state with retained and normally functioning ovaries. Shethen underwent ovarian ablation by radiotherapy, after which she was administered2.5 mg of letrozole once per day. Three months later, the size of the metastaticnodules in both lungs had decreased. The patient was followed up for 24 monthswhile continuing on letrozole, and maintained a partial remission. We report hereinon a case of metastatic LG-ESS treated with letrozole after ovarian ablation by radiotherapy.
참고문헌 (15)
- Koss LG, "Endometrial stromal sarcoma", Surg Gynecol Obstet, 121, pp.531~537 (1965)
- Norris HJ, "Mesenchymal tumors of the uterus. I. A clinical and pathological study of 53 endometrial stromal tumors", Cancer, 19, pp.755~766 (1966)
- Leath CA 3rd, "A multi-institutional review of outcomes of endometrial stromal sarcoma", Gynecol Oncol, 105, pp.630~634 (2007)
- Bodner K, "Prognostic parameters in endometrial stromal sarcoma : a clinicopathologic study in 31 patients", Gynecol Oncol, 81, pp.160~165 (2001)
- Li N, "Treatment options in stage I endometrial stromal sarcoma : a retrospective analysis of 53 cases", Gynecol Oncol, 108, pp.306~311 (2008)
- Gadducci A, "The management of patients with uterine sarcoma : a debated clinical challenge", Crit Rev Oncol Hematol, 65, pp.129~142 (2008)
- Chu MC, "Low-grade endometrial stromal sarcoma : hormonal aspects", Gynecol Oncol, 90, pp.170~176 (2003)
- Li AJ, "Ovarian preservation in stage I low-grade endometrial stromal sarcomas", Obstet Gynecol, 106, pp.1304~1308 (2005)
- Pink D, "Harm or benefit of hormonal treatment in metastatic low-grade endometrial stromal sarcoma : single center experience with 10 cases and review of the literature", Gynecol Oncol, 101, pp.464~469 (2006)
- Pellillo D., "Proliferative stromatosis of the uterus with pulmonary metastases. Remission following treatment with a longacting synthetic progestin: a case report", Obstet Gynecol, 31, pp.33~39 (1968)
- Garavaglia E, "Treatment of recurrent or metastatic low-grade endometrial stromal sarcoma : three case reports", Int J Gynecol Cancer, 20, pp.1197~1200 (2010)
- Maluf FC, "Endometrial stromal sarcoma : objective response to letrozole", Gynecol Oncol, 82, pp.384~388 (2001)
- Shoji K, "Aromatase inhibitor anastrozole as a second-line hormonal treatment to a recurrent low-grade endometrial stromal sarcoma : a case report", Med Oncol, 28, pp.771~774 (2011)
- Dombernowsky P, "Letrozole, a new oral aromatase inhibitor for advanced breast cancer : double-blind randomized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate", J Clin Oncol, 16, pp.453~461 (1998)
- Wysowski DK, "Uterine sarcoma associated with tamoxifen use", N Engl J Med, 346, pp.1832~1833 (2002)