Long-term Outcome of Chondrosarcoma: A Single Institutional Experience
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Purpose The prognostic factors of chondrosarcoma remain uncertain as only a few large studies withlong-term follow-up have been reported. The aim of this study was to analyze oncologicaloutcomes and prognostic factors. Materials and MethodsA retrospective review of oncological outcomes and prognostic factors was performed on125 consecutive chondrosarcoma patients who underwent surgery at our institution. ResultsOverall survival was 91.6%±2.5%, 84.1%±3.8%, and 84.1%±3.8% at 5, 10, and 15 yearsrespectively. Among the histological types, dedifferentiated type showed the worst survival(p < 0.001). As for conventional type chondrosarcoma, histologic grade and anatomicallocation predicted outcome, with high-grade with axial location having the worst outcome(p < 0.001). In contrast, low-grade chondrosarcoma of appendicular skeleton could betreated safely by intralesional curettage. ConclusionHistological type was significantly associated with the outcome of chondrosarcoma. For theconventional type, histologic grade and anatomical location predicted outcome, with highgradewith axial location having the worst outcome.
Abstract
Purpose The prognostic factors of chondrosarcoma remain uncertain as only a few large studies withlong-term follow-up have been reported. The aim of this study was to analyze oncologicaloutcomes and prognostic factors. Materials and MethodsA retrospective review of oncological outcomes and prognostic factors was performed on125 consecutive chondrosarcoma patients who underwent surgery at our institution. ResultsOverall survival was 91.6%±2.5%, 84.1%±3.8%, and 84.1%±3.8% at 5, 10, and 15 yearsrespectively. Among the histological types, dedifferentiated type showed the worst survival(p < 0.001). As for conventional type chondrosarcoma, histologic grade and anatomicallocation predicted outcome, with high-grade with axial location having the worst outcome(p < 0.001). In contrast, low-grade chondrosarcoma of appendicular skeleton could betreated safely by intralesional curettage. ConclusionHistological type was significantly associated with the outcome of chondrosarcoma. For theconventional type, histologic grade and anatomical location predicted outcome, with highgradewith axial location having the worst outcome.
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