Prevalence of Women with Dense Breasts in Korea: Results from a Nationwide Cross-sectional Study
2
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
Purpose Women with dense breast are known to be at high risk for breast cancer, but their prevalence and number of Korean women are unknown. The current study was to investigate the distribution of mammographic breast density by age of women undergoing screening mammography, and to estimate the prevalence of Korean women with dense breasts, quantitatively. Materials and Methods For obtaining a nationwide representative sample, 6,481 mammograms were collected from 86 screening units participated in the National Cancer Screening Program for breast cancer. Based on the American College of Radiology Breast Imaging Reporting and Data System classification, breast density was evaluated by six breast radiologists, qualitatively. We applied these breast density distributions to age-specific counts of the Korean women population derived to mid-year 2017 to estimate the number of Korean women with dense breasts. Results Overall, 54.4% (95% confidence interval [CI], 52.9% to 55.8%) of women 40 to 69 years of age had heterogeneously or extremely dense breasts, and this proportion was inversely associated with age. Based on the age distribution of Korean women, we estimated that 6,083,000 women (95% CI, 5,919,600 to 6,245,600) age 40-69 years in Korean have dense breasts. Women aged 40-49 years (n=3,450,000) accounted for 56.7% of this group. Conclusion More than half of Korean women aged 40 and over have dense breasts. To prevent breast cancer effectively and efficiently, it is necessary to develop a new personalized prevention strategy considering her status of breast density.
Abstract
Purpose Women with dense breast are known to be at high risk for breast cancer, but their prevalence and number of Korean women are unknown. The current study was to investigate the distribution of mammographic breast density by age of women undergoing screening mammography, and to estimate the prevalence of Korean women with dense breasts, quantitatively. Materials and Methods For obtaining a nationwide representative sample, 6,481 mammograms were collected from 86 screening units participated in the National Cancer Screening Program for breast cancer. Based on the American College of Radiology Breast Imaging Reporting and Data System classification, breast density was evaluated by six breast radiologists, qualitatively. We applied these breast density distributions to age-specific counts of the Korean women population derived to mid-year 2017 to estimate the number of Korean women with dense breasts. Results Overall, 54.4% (95% confidence interval [CI], 52.9% to 55.8%) of women 40 to 69 years of age had heterogeneously or extremely dense breasts, and this proportion was inversely associated with age. Based on the age distribution of Korean women, we estimated that 6,083,000 women (95% CI, 5,919,600 to 6,245,600) age 40-69 years in Korean have dense breasts. Women aged 40-49 years (n=3,450,000) accounted for 56.7% of this group. Conclusion More than half of Korean women aged 40 and over have dense breasts. To prevent breast cancer effectively and efficiently, it is necessary to develop a new personalized prevention strategy considering her status of breast density.
참고문헌 (29)
- Boyd NF, "Mammographic density and breast cancer risk : current understanding and future prospects", Breast Cancer Res, 13, pp.223~ (2011)
- Astley SM, "A comparison of five methods of measuring mammographic density : a case-control study", Breast Cancer Res, 20, pp.10~ (2018)
- 배종면, "Breast Density and Risk of Breast Cancer in Asian Women: A Meta-analysis of Observational Studies", 예방의학회지, 49(6), pp.367~375 (2016), 대한예방의학회
- Park B, "Does breast density measured through population-based screening independently increase breast cancer risk in Asian females?", Clin Epidemiol, 10, pp.61~70 (2018)
- Nyante SJ, "Prognostic significance of mammographic density change after initiation of tamoxifen for ER-positive breast cancer", J Natl Cancer Inst, 107, pp.dju425~ (2015)
- Tice JA, "Using clinical factors and mammographic breast density to estimate breast cancer risk : development and validation of a new predictive model", Ann Intern Med, 148, pp.337~347 (2008)
- Trentham-Dietz A, "Tailoring breast cancer screening intervals by breast density and risk for women aged 50years or older : collaborative modeling of screening outcomes", Ann Intern Med, 165, pp.700~712 (2016)
- Holm J, "Risk factors and tumor characteristics of interval cancers by mammographic density", J Clin Oncol, 33, pp.1030~1037 (2015)
- Boyd NF, "Mammographic breast density as an intermediate phenotype for breast cancer", Lancet Oncol, 6, pp.798~808 (2005)
- Maskarinec G, "Comparison of mammographic densities and their determinants in women from Japan and Hawaii", Int J Cancer, 102, pp.29~33 (2002)
- Maskarinec G, "Ethnic and geographic differences in mammographic density and their association with breast cancer incidence", Breast Cancer Res Treat, 104, pp.47~56 (2007)
- Mariapun S, "Ethnic differences in mammographic densities: an Asian cross-sectional study", PLoS One, 10, pp.e0117568~ (2015)
- McCormack VA, "Ethnic variations in mammographic density : a British multiethnic longitudinal study", Am J Epidemiol, 168, pp.412~421 (2008)
- Habel LA, "Mammographic density in a multiethnic cohort", Menopause, 14, pp.891~899 (2007)
- Kim SH, "Analysis and comparison of breast density according to age on mammogram between Korean and western women", J Korean Radiol Soc, 42, pp.1009~1014 (2000)
- 윤인영, "Mammographic Breast Density Evaluation in Korean Women Using Fully Automated Volumetric Assessment", Journal of Korean Medical Science, 31(3), pp.457~462 (2016), 대한의학회
- Sprague BL, "Prevalence of mammographically dense breasts in the United States", J Natl Cancer Inst, 106, pp.dju255~ (2014)
- Dai H, "Distribution of mammographic density and its influential factors among Chinese women", Int J Epidemiol, 43, pp.1240~1251 (2014)
- Jun JK, "Development of a sampling strategy and sample size calculation to estimate the distribution of mammographic breast density in Korean women", Asian Pac J Cancer Prev, 13, pp.4661~4664 (2012)
- Breast Imaging Reporting and Data System, "American College of Radiology", American College of Radiology, ~ (2003)
- Jo HM, "Interpretive volume and inter-radiologist agreement on assessing breast density", J Korean Soc Breast Screening, 15, pp.15~22 (2018)
- Ishihara S, "Association between mammographic breast density and lifestyle in Japanese women", Acta Med Okayama, 67, pp.145~151 (2013)
- 서미나, "Trends in Participation Rates for the National Cancer Screening Program in Korea, 2002-2012", Cancer Research and Treatment, 49(3), pp.798~806 (2017), 대한암학회
- 이은혜, "Performance of Screening Mammography: A Report of the Alliance for Breast Cancer Screening in Korea", Korean Journal of Radiology, 17(4), pp.489~496 (2016), 대한영상의학회[DOI]
- 김영중, "Analysis of Participant Factors That Affect the Diagnostic Performance of Screening Mammography: A Report of the Alliance for Breast Cancer Screening in Korea", Korean Journal of Radiology, 18(4), pp.624~631 (2017), 대한영상의학회[DOI]
- "Woodbury" (2018)[URL]
- 이은혜, "유방암 검진 권고안 개정안", 대한의사협회지, 58(5), pp.408~419 (2015), 대한의사협회[DOI]
- 정규원, "Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2015", Cancer Research and Treatment, 50(2), pp.303~316 (2018), 대한암학회
- 정규원, "Prediction of Cancer Incidence and Mortality in Korea, 2018", Cancer Research and Treatment, 50(2), pp.317~323 (2018), 대한암학회