본문 바로가기
KERD
논문KCI 등재

Neurocognitive Effects of Chemotherapy for Colorectal Cancer: A Systematic Review and a Meta-Analysis of 11 Studies

2

조회

0

다운로드

1

인용

0

참고문헌

키워드

주제분류의학일반

초록

Purpose Chemotherapy-related cognitive impairment (CRCI) is a controversial concept not much explored on colorectal cancer patients. Materials and Methods We identified 11 prospective studies: eight studies on 696 colorectal cancer patients who received chemotherapy and three studies on 346 rectal cancer patients who received neoadjuvant chemoradiotherapy. Standardized mean differences (SMDs) of neuropsychological test results and the cognitive quality-of-life scale were calculated using random effect models. A meta-regression was conducted to investigate the association between mean study population age and effect sizes. Results The association between chemotherapy and cognitive impairment was not clear in colorectal cancer patients (SMD, 0.003; 95% confidence interval, –0.080 to 0.086). However, a meta-regression showed that older patients are more vulnerable to CRCI than younger patients (β=–0.016, p < 0.001). Conclusion Chemotherapy has an overall positive negligible effect size on the cognitive function of colorectal patients. Age is a significant moderator of CRCI.

Abstract

Purpose Chemotherapy-related cognitive impairment (CRCI) is a controversial concept not much explored on colorectal cancer patients. Materials and Methods We identified 11 prospective studies: eight studies on 696 colorectal cancer patients who received chemotherapy and three studies on 346 rectal cancer patients who received neoadjuvant chemoradiotherapy. Standardized mean differences (SMDs) of neuropsychological test results and the cognitive quality-of-life scale were calculated using random effect models. A meta-regression was conducted to investigate the association between mean study population age and effect sizes. Results The association between chemotherapy and cognitive impairment was not clear in colorectal cancer patients (SMD, 0.003; 95% confidence interval, –0.080 to 0.086). However, a meta-regression showed that older patients are more vulnerable to CRCI than younger patients (β=–0.016, p < 0.001). Conclusion Chemotherapy has an overall positive negligible effect size on the cognitive function of colorectal patients. Age is a significant moderator of CRCI.

참고문헌 (51)

  1. Bray F, "Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries", CA Cancer J Clin, 68, pp.394~424 (2018)
  2. van Dam FS, "Impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer : high-dose versus standard-dose chemotherapy", J Natl Cancer Inst, 90, pp.210~218 (1998)
  3. Anderson-Hanley C, "Neuropsychological effects of treatments for adults with cancer : a meta-analysis and review of the literature", J Int Neuropsychol Soc, 9, pp.967~982 (2003)
  4. Cruzado JA, "Longitudinal study of cognitive dysfunctions induced by adjuvant chemotherapy in colon cancer patients", Support Care Cancer, 22, pp.1815~1823 (2014)
  5. Vardy JL, "Cognitive function in patients with colorectal cancer who do and do not receive chemotherapy : a prospective, longitudinal, controlled study", J Clin Oncol, 33, pp.4085~4092 (2015)
  6. Seigers R, "Neurobiological basis of chemotherapyinduced cognitive impairment : a review of rodent research", Neurosci Biobehav Rev, 35, pp.729~741 (2011)
  7. Branca JJ, "Oxaliplatin-induced blood brain barrier loosening : a new point of view on chemotherapy-induced neurotoxicity", Oncotarget, 9, pp.23426~23438 (2018)
  8. Wigmore PM, "Effects of 5-FU", Adv Exp Med Biol, 678, pp.157~164 (2010)
  9. Vardy JL, "Cancer-induced cognitive impairment : practical solutions to reduce and manage the challenge", Future Oncol, 13, pp.767~771 (2017)
  10. Fernandes HA, "Cognitive rehabilitation for cancer-related cognitive dysfunction : a systematic review", Support Care Cancer, 27, pp.3253~3279 (2019)
  11. Ahles TA, "Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer : impact of age and cognitive reserve", J Clin Oncol, 28, pp.4434~4440 (2010)
  12. Bleecker ML, "Impact of cognitive reserve on the relationship of lead exposure and neurobehavioral performance", Neurology, 69, pp.470~476 (2007)
  13. Anstey KJ, "Selfreported history of chemotherapy and cognitive decline in adults aged 60 and older : the PATH Through Life Project", J Gerontol A Biol Sci Med Sci, 70, pp.729~735 (2015)
  14. Lee SH, "Quality of life changes during adjuvant chemotherapy in patients with colon cancer", Korean J Clin Oncol, 12, pp.60~66 (2016)
  15. Andreis F, "Lack of a chemobrain effect for adjuvant FOLFOX chemotherapy in colon cancer patients : a pilot study", Support Care Cancer, 21, pp.583~590 (2013)
  16. Sales MV, "Effects of adjuvant chemotherapy on cognitive function of patients eith rarly-stage volorectal vancer", Clin Colorectal Cancer, 18, pp.19~27 (2019)
  17. Mayrbaurl B, "Quality of life across chemotherapy lines in patients with advanced colorectal cancer : a prospective single-center observational study", Support Care Cancer, 24, pp.667~674 (2016)
  18. Tsunoda A, "Health-related quality of life in patients with colorectal cancer who receive oral uracil and tegafur plus leucovorin", Jpn J Clin Oncol, 40, pp.412~419 (2010)
  19. Couwenberg AM, "Effect of neoadjuvant therapy and rectal surgery on health-related quality of life in patients with rectal cancer during the first 2 years after diagnosis", Clin Colorectal Cancer, 17, pp.e499~512 (2018)
  20. Souza J, "Health-related quality of life assessment in patients with rectal cancer treated with curative intent", Arq Gastroenterol, 55, pp.154~159 (2018)
  21. Bencova V, "Indication of pre-surgical radiochemotherapy enhances psychosocial morbidity among patients with resectable locally advanced rectal cancer", Neoplasma, 63, pp.635~641 (2016)
  22. Horowitz TS, "Understanding the profile of cancer-related cognitive impairments : a critique of meta-analyses", J Natl Cancer Inst, 111, pp.1009~1015 (2019)
  23. Fayers P, "EORTC QLQ-C30 scoring manual" (2001), European Organisation for Research and Treatment of Cancer
  24. Higgins JP, "Measuring inconsistency in meta-analyses", BMJ, 327, pp.557~560 (2003)
  25. "The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses" (2021)[URL]
  26. Luchini C, "Assessing the quality of studies in meta-analyses : advantages and limitations of the Newcastle Ottawa Scale", World J Meta-Anal, 5, pp.80~84 (2017)
  27. Faraone SV, "Interpreting estimates of treatment effects : implications for managed care", P T, 33, pp.700~711 (2008)
  28. Hodgson KD, "A meta-analysis of the effects of chemotherapy on cognition in patients with cancer", Cancer Treat Rev, 39, pp.297~304 (2013)
  29. Bernstein LJ, "Cognitive impairment in breast cancer survivors treated with chemotherapy depends on control group type and cognitive domains assessed : a multilevel meta-analysis", Neurosci Biobehav Rev, 83, pp.417~428 (2017)
  30. Jansen CE, "A metaanalysis of studies of the effects of cancer chemotherapy on various domains of cognitive function", Cancer, 104, pp.2222~2233 (2005)
  31. Falleti MG, "The nature and severity of cognitive impairment associated with adjuvant chemotherapy in women with breast cancer : a metaanalysis of the current literature", Brain Cogn, 59, pp.60~70 (2005)
  32. Stewart A, "A meta-analysis of the neuropsychological effects of adjuvant chemotherapy treatment in women treated for breast cancer", Clin Neuropsychol, 20, pp.76~89 (2006)
  33. Ono M, "A meta-analysis of cognitive impairment and decline associated with adjuvant chemotherapy in women with breast cancer", Front Oncol, 5, pp.59~ (2015)
  34. Jim HS, "Meta-analysis of cognitive functioning in breast cancer survivors previously treated with standard-dose chemotherapy", J Clin Oncol, 30, pp.3578~3587 (2012)
  35. Lindner OC, "A meta-analysis of cognitive impairment following adult cancer chemotherapy", Neuropsychology, 28, pp.726~740 (2014)
  36. Bartels C, "Practice effects in healthy adults : a longitudinal study on frequent repetitive cognitive testing", BMC Neurosci, 11, pp.118~ (2010)
  37. Lezak MD, "Neuropsychological assessment" (2004), Oxford University Press
  38. McCaffrey RJ, "Practitioner’s guide to evaluating change with neuropsychological assessment instruments" (2000), Springer Science & Business Media
  39. McCaffrey RJ, "Issues associated with repeated neuropsychological assessments", Neuropsychol Rev, 5, pp.203~221 (1995)
  40. Dodge HH, "Cohort effects in age-associated cognitive trajectories", J Gerontol A Biol Sci Med Sci, 69, pp.687~694 (2014)
  41. Dodge HH, "Cohort effects in verbal memory function and practice effects : a population-based study", Int Psychogeriatr, 29, pp.137~148 (2017)
  42. Wefel JS, "International Cognition and Cancer Task Force recommendations to harmonise studies of cognitive function in patients with cancer", Lancet Oncol, 12, pp.703~708 (2011)
  43. Pendergrass JC, "Cognitive impairment associated with cancer : a brief review", Innov Clin Neurosci, 15, pp.36~44 (2018)
  44. Hardy SJ, "Cognitive changes in cancer survivors", Am Soc Clin Oncol Educ Book, 38, pp.795~806 (2018)
  45. Anampa J, "Progress in adjuvant chemotherapy for breast cancer : an overview", BMC Med, 13, pp.195~ (2015)
  46. Bianchi E, "Apoptotic process induced by oxaliplatin in rat hippocampus causes memory impairment", Basic Clin Pharmacol Toxicol, 120, pp.14~21 (2017)
  47. Fardell JE, "Cognitive impairments caused by oxaliplatin and 5-fluorouracil chemotherapy are ameliorated by physical activity", Psychopharmacology(Berl), 220, pp.183~193 (2012)
  48. Vega JN, "Cognitive effects of chemotherapy and cancer-related treatments in older adults", Am J Geriatr Psychiatry, 25, pp.1415~1426 (2017)
  49. Maccormick RE, "Possible acceleration of aging by adjuvant chemotherapy: a cause of early onset frailty?", Med Hypotheses, 67, pp.212~215 (2006)
  50. Ahles TA, "Candidate mechanisms for chemotherapy-induced cognitive changes", Nat Rev Cancer, 7, pp.192~201 (2007)
  51. Dikmen SS, "Test-retest reliability and practice effects of expanded Halstead-Reitan Neuropsychological Test Battery", J Int Neuropsychol Soc, 5, pp.346~356 (1999)

관련 논문AI추천

이 간행물의 다른 논문 (30건)