HIF-1alpha: a Valid Therapeutic Target for Tumor Therapy

키워드

참고문헌 (109)

1. "Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor", medulloblastomamodels as single agent and in combination chemotherapy, 2001, pp.61, 1527~32
2. "Angiogenesis in cancer and other disease", 407, pp.249~57 (2000)
3. "Molecular pathology of cyclooxygenase-2 in neoplasia", 30, pp.3~21 (2000)
4. "master and commander of thehypoxic world A pharmacological approach to its regulationby siRNAs", pp.971~1 80 (2004)
5. "The effect of trastuzumab", docatexel combination on breast cancer angiogenesis dichotomus effect predictable by the HIFI alpha, pp.2003[DOI]
6. "Targeting HIF-1 for cancer therapy", 3, pp.721~32 (2003)
7. "Early stages of multistephepatocarcinogenesis", 22, pp.172~8 (1999)
8. "Dramatic effect of ZD1839 ('Iressa') in a patientwith advanced non-small-cell lung cancer and poor performancestatus", 40, pp.73~6 (2003)
9. "Prostaglandin E2 induces hypoxia-induciblefactor-1alpha stabilization and nuclear localization in a humanprostate cancer cell line", 277, pp.50081~6 (2002)
10. "Effect of protein kinaseand phosphatase inhibitors on expression of HIF-1", 216, pp.669~75 (1995)
11. "and transactivation properties of HIF-1α", pp.17771~8 (1996)
12. "and enhance the transcriptionalactivity of HIF-1", pp.32631~7 (1999)
13. "The thioredoxin redox inhibitors 1-methylpropyl2-imidazolyl disulfide and pleurotin inhibithypoxia- induced factor 1alpha and vascular endothelialgrowth factor formation", 2, pp.235~43 (2003)
14. "Identification of amino acid residues critical for transcriptionalactivation and", or interaction with CREB-binding protein, 2002, 38723~30
15. "Reduction of hypoxia-induced transcription through therepression of hypoxia-inducible factor-1alpha", aryl hydrocarbonreceptor nuclear translocator DNA binding by the 90-kDaheat-shock protein inhibitor radicicol, 2002, pp.62, 975~82
16. "a transcription factor selectively expressed in endothelialcells", pp.72~82 (1997)
17. "angiogenesis and growth of human breastcancer xenografts", so(o h), pp.1342~51 (2001), inhibits expressionof hypoxia-inducible factor-1alpha and vascular endothelialgrowth factor
18. "Identificationof alternative spliced variants of human hypoxicinduciblefactor-1alpha", 275, pp.6922~7 (2000)
19. "structural requirementof bisphenol A for degradation of HIF-1alpha", pp.1006~11 (2004)
20. "Anew HIF-1 alpha variant induced by zinc ion suppresses HIF-1- mediated hypoxic responses", 114, pp.4051~61 (2001)
21. "Berberineinhibits HIF-1alpha expression via enhanced proteolysis", 66, pp.612~9 (2004)
22. "A dominantnegativeisoform lacking exon 11 and 12 of the humanhypoxic- inducible factor-1 α gene", 362, pp.71~9 (2002)
23. "an inhibitor of hypoxia-inducible factor-1alpha", pp.233~478 44 (2004)
24. "Phorbol ester stimulates the nonhypoxic induction of anovel hypoxia-inducible factor 1α isoform:implications fortumor promotion", 63, pp.8700~7 (2003)
25. "GL331 inhibits HIF-1alpha expression in a lung cancermodel", 302, pp.95~100 (2003)
26. "Non-hypoxic transcriptional activationof the aryl hydrocarbon receptor nuclear translocator inconcert with a novel hypoxia-inducible factor-1alpha isoform", 32, pp.5499~511 (2004)
27. "HIFalpha targeted for VHL-mediated destruction by prolinehydroxylation:implications for O2 sensing", 292, pp.464~8 (2001)
28. "Hepatitis B virus X protein induces angiogenesisby stabilizing hypoxia-inducible factor-1α", 18, pp.382~4 (2004)
29. "Independent function of two destruction domains in hypoxiainduciblefactor-alpha chains activated by prolyl hydroxylation", 20, pp.5197~206 (2001)
30. "Tid-1 interacts with pVHL and modulates angiogenesisby destabilization of HIF-1α"
31. "The tumour suppressor protein VHL targets hypoxiainduciblefactors for oxygen-dependent proteolysis", 399, pp.271~5 (1999)
32. "Mechanismof regulation of the hypoxia inducible factor-1 alpha by thevon Hipple-Lindau tumor suppressor protein", 19, pp.4298~309 (2000)
33. "Multiple splice variants of the human HIF-3alpha locus aretargets of the VHL E3 ubiquitin ligase complex", 278, pp.11032~40 (2003)
34. "is a hypoxia-induciblesplicing variant of the hypoxia-inducible factor-3α locus", pp.32405~8 (2002)
35. "Hypoxia rapidly activates HIF-3α mRNAexpression", 17, pp.1541~3 (2003)
36. "Expression of hypoxia-induciblefactor-1alpha and -2alpha in hypoxic and ischemic rat kidneys", 13, pp.1974~6 (2002)
37. "The contribution of VHL substrate bindingand HIF-1alphaz to the phenotype of VHL loss in renal cellcarcinoma", 1, pp.247~55 (2002)
38. "Inhibition of HIF is necessary for tumor suppression by thevon Hippel Lindau protein", 1, pp.237~46 (2002)
39. "Relationship of hypoxia-inducible factor -1alpha andHIF-2alpha expression to vascular endothelial growth factorinduction and hypoxia survival in human breast cancer celllines", pp.7106~13 (2002)
40. "Hypoxia-inducible factor-1a is modified by covalentattachment to SUMO Biology of Hypoxia The Role of Oxygen Sensing in Development", (rmal function and disease) (2004)
41. "Expression of vascularendothelial growth factor in surgical specimens of hepatocellularcarcinoma", 126, pp.153~60 (2000)
42. "MAP kinases and hypoxiain the control of VEGF expression", 19, pp.139~45 (2000)
43. "Molecular mechanismsof blood vessel growth", 49, pp.507~21 (2001)
44. "target for anti-vascularendothelial growth factor", pp.32~6 (2000)
45. "A hypoxia-responsive element mediates a novel pathway ofactivation of the inducible nitric oxide synthase promoter", 182, pp.1683~93 (1995)
46. "Hypoxiainduces type II NOS gene expression in pulmonary arteryendothelial cells via HIF-1", 274, pp.212~9 (1998)
47. "Hypoxia-inducible factor-1 mediates transcriptional activationof the heme oxygenase-1 gene in response to hypoxia", 272, pp.5375~81 (1997)
48. "Hypoxiaregulates expression of the endothelin-1 gene through aproximal hypoxia-inducible factor-1 binding site on theantisense strand", 245, pp.894~9 (1998)
49. "Hypoxia regulates the expressionof the adrenomedullin and HIF-1 genes in cultured HL-1 cardiomyocytes", 265, pp.382~6 (1999)
50. "Characterization ofthe alpha1B-adrenergic receptor gene promoter region andhypoxia regulatory elements in vascular smooth muscle", 94, pp.9487~92 (1997)
51. "Cellular adaptation to hypoxia", pp.1151~62 (2002), and O2-regulated gene expression
52. "Regulation of colon carcinoma cell invasionby hypoxia- inducible factor 1", 63, pp.1138~43 (2003)
53. "Reciprocal positive regulation of hypoxia-inducible factor1alpha and insulin-like growth factor 2", 59, pp.3915~8 (1999)
54. "Hypoxiaactivates a platelet-derived growth factor receptor", phosphatidylinositol3-kinase, pp.2001, 61[DOI]
55. "Loss of PTEN facilitates HIF-1- mediated geneexpression", 14, pp.391~6 (2000)
56. "Hypoxia--a key regulatory factor in tumour growth", 2, pp.38~47 (2002)
57. "Oncogenic alterations of metabolism", 24, pp.68~72 (1999)
58. "Transcription factor HIF-1 is a necessarymediator of the pasteur effect in mammalian cells", 21, pp.3436~44 (2001)
59. "Regulationof glut1 mRNA by hypoxia-inducible factor-1", pp.9519~25 (2001)
60. "Hypoxia-inducible expression of tumorassociatedcarbonic anhydrases", 60, pp.7075~83 (2000)
61. "The role of phosphometabolitesin cell proliferation", pp.315~30 (1997)
62. "Activation ofHIF depends primarily upon redox-sensitive stabilization of itsalpha subunit", pp.32253~9 (1996)
63. "Activation of hypoxia-inducible factor 1alpha posttranscriptionalregulation and conformational change by recruitment ofthe Arnt transcription factor", pp.5667~72 (1997)
64. "Structural basis for the recognition ofhydroxyproline in HIF-1α by pVHL", 417, pp.975~8 (2002)
65. "Structure of an HIF-1α-pVHL complex:Hydroxyprolinerecognition in signalling", 296, pp.1886~9 (2002)
66. "Sequence determinantsin hypoxia inducible factor-1α for hydroxylation by the prolylhydroxylases PHD1", pp.39792~800 (2002)
67. "Intracellular localization of human HIF-1α hydroxylases Implications for oxygen sensing", pp.1319~26 (2003)
68. "Induction of Hif-1alpha in response to hypoxiais instantaneous", 15, pp.1312~4 (2001)
69. "Regulation and destabilization of HIF-1alpha byARD1-mediated acetylation", 111, pp.709~20 (2002)
70. "Isolation of new genes in distal Xq28:transcriptionalmap and identification of a human holologue of the ARD1N-acetyl transferase of Saccharomyces cerevisiae", 3, pp.1061~7 (1994)
71. "Genetic manipulation indicatesthat ARD1 is an essential N-acetyltransferase in Trypansomabrucei", 111, pp.309~17 (2000)
72. "Mechanismof regulation of the hypoxia-inducible factor-1 alpha by thevon Hippel-Lindau tumor suppressor protein", 19, pp.4298~309 (2000)
73. "Sumoylation increases HIF-1alpha stability and its transcriptionalactivity", 324, pp.394~400 (2004)
74. "The expression and distribution of thehypoxia-inducible factors HIF-1alpha and HIF-2alpha innormal human tissues,cancers,and tumor-associated macrophages", 157, pp.411~21 (2000)
75. "Overexpression of hypoxia-inducible factor1alpha in common human cancers and their metastases", 59, pp.5830~5 (1999)
76. "Inductionof vascular endothelial growth factor by hypoxia is modulatedby a phosphatidylinositol 3-kinase", Akt signaling pathway inHa-ras-transformed cells through a hypoxia inducible factor-1transcriptional element, 1997, pp.90, 3322~31
77. "Oxygen-dependentregulation of hypoxia-inducible factors by prolyl andasparaginyl hydroxylation", 270, pp.781~90 (2003)
78. "The hypoxia- inducible factor-1 alpha isa negative factor for tumor therapy", 22, pp.3213~20 (2003)
79. "Expression of hypoxia-inducible factor- 1alpha:a novel predictive and prognostic parameter in the radiotherapyof oropharyngeal cancer", 61, pp.2911~6 (2001)
80. "Gene transfer of antisense hypoxia inducible factor-1alpha enhances the therapeutic efficacy of cancer immunotherapy", 8, pp.638~45 (2001)
81. "Suppression of tumor growth through disruption of hypoxiainducibletranscription", 6, pp.1335~40 (2000)
82. "Hsp90 regulates a von Hippel Lindau-independenthypoxia-inducible factor-1 alpha-degradative pathway", 277, pp.29936~44 (2002)
83. "Geldanamycin induces degradation ofhypoxia- inducible factor 1alpha protein via the proteasomepathway in prostate cancer cells", 62, pp.2478~82 (2002)
84. "Geldanamycin inhibits migration ofglioma cells in vitro a potential role for hypoxia-induciblefactor", pp.394~402 (2003)
85. "YC-1:a potential anticancer drug targeting hypoxia-induciblefactor 1", 95, pp.516~25 (2003)
86. "2ME2 inhibits tumor growth andangiogenesis by disrupting microtubules and dysregulatingHIF", 3, pp.363~75 (2003)
87. "Targeting gene expression to hypoxictumor cells", 3, pp.515~20 (1997)
88. "Anaerobic bacteria as a gene delivery systemthat is controlled by the tumor microenvironment", 4, pp.791~6 (1997)
89. "Hypoxia-inducible factor1alpha protein expression is controlled by oxygen-regulatedubiquitination that is disrupted by deletions and missensemutations", 97, pp.4748~53 (2000)
90. "Hypoxia inducible factor-alpha binding andubiquitylation by the von Hippel-Lindau tumor suppressorprotein", 275, pp.25733~41 (2000)
91. "Activation of HIF1alpha ubiquitination by areconstituted von Hippel-Lindau", pp.10430~5 (2000), tumor suppressor complex
92. "protein is rapidly degraded by the ubiquitin-proteasomesystem under normoxic conditions Its stabilization byhypoxia depends on redox-induced changes", pp.22642~7 (1997)
93. "Regulation of tumor angiogenesis by p53-induceddegradation of hypoxia-inducible factor 1alpha", 14, pp.34~44 (2000)
94. "Stabilization of wild-type p53 by hypoxiainduciblefactor 1alpha", 392, pp.405~8 (1998)
95. "Molecular mechanisms of transcription activation by HLFand HIF1alpha in response to hypoxia:their stabilization andredox signal-induced interaction with CBP", p300, 1999, pp.18, 1905~14
96. "An essential role for p300", CBP in the cellularresponse to hypoxia, 1996, pp.93, 12969~73
97. "Redox-regulated recruitment of the transcriptionalcoactivators CREB-binding protein and SRC-1 tohypoxia- inducible factor 1alpha", 20, pp.402~15 (2000)
98. "Hypoxia-induced activation of HIF-1:role of HIF-1alpha-Hsp90 interaction", 460, pp.251~6 (1999)
99. "Jab1 interacts directly with HIF- 1alpha and regulatesits stability", 277, pp.9~12 (2002)
100. "mediator of physiological and pathophysiologicalresponses to hypoxia", pp.1474~1 80 (2000)
101. "Overexpression of hypoxiainduciblefactor 1alpha is associated with an unfavorableprognosis in lymph node-positive breast cancer", 8, pp.1831~7 (2002)
102. "Significant correlation of hypoxia-induciblefactor-1alpha with treatment outcome in cervical cancer treatedwith radical radiotherapy", 56, pp.494~501 (2003)
103. "Expression of hypoxia- inducible factor-1alpha in oligodendrogliomas:its impact on prognosis and onneoangiogenesis", 92, pp.165~71 (2001)
104. "Relation of hypoxia inducible factor1 alpha and 2 alpha in operable non-small cell lung cancer toangiogenic", molecular profile of tumours and survival, 2001, pp.85, 881~90
105. "Hypoxia-inducible factor-1alpha expression andangiogenesis in gastrointestinal stromal tumor of the stomach", 10, pp.797~802 (2003)
106. "Hypoxia-inducible factors HIF- 1alpha and HIF-2alphain head and neck cancer:relationship to tumor biology andtreatment outcome in surgically resected patients", 62, pp.2493~7 (2002)
107. "expression in early esophageal cancerand response to photodynamic therapy and radiotherapy"
108. "Discovery of anovel Raf kinase inhibitor", 8, pp.219~25 (2001)
109. "Identification of small moleculeinhibitors of hypoxia-inducible factor 1 transcriptionalactivation pathway", 62, pp.4316~24 (2002)

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