Metachronous Double Primary Cancer after Diagnosis of Gastric Cancer
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Purpose The pattern of double primary cancers after treatment for gastric cancer is important for a patient's survival. Materials and Methods We analyzed the clinicopathologic data of 214 gastric cancer patients from October 1996 to November 2007 with regard to metachronous second primary cancers. Results Out of 5,778 patients with gastric cancer, metachronous second primary cancers occurred in 214patients. The median age was 61.8 years, the number of male and female patients was 140 (65.4%),74 (34.6%), respectively. The median time to the occurrence of second cancers after diagnosis of the first was 39.2 months (standard deviation, 31.2 months). The most common cancer was colorectal cancer, which occurred in 44 patients (20.6%), and lung cancer in 33 patients (15.4%),hepatocellular carcinoma in 26 patients (12.1%), ovarian cancer in 15 patients (7.0%), cervical cancer in 12 patients (7.0%), breast cancer in 11 patients (5.1%), and esophageal cancer in 11patients (5.1%). The observed/expected (O/E) ratio showed a significant increase in colorectal (1.25), male biliary (1.60), ovarian (8.72), and cervical cancer (3.33) with primary gastric cancer. After five years from diagnosis of gastric cancer, secondary cancer occurred in 50 patients (23.4%), and breast cancer, prostate cancer, laryngeal cancer, lung cancer, and hepatocellular carcinoma were the most frequent. Conclusion The O/E ratio showed a significant increase in colorectal, male biliary, ovarian, and cervical cancer with primary gastric cancer, and second primary cancer as the main cause of death for these patients. A follow-up examination for metachronous double primary cancer is needed in order to improve the survival time in patients with gastric cancer.
Abstract
Purpose The pattern of double primary cancers after treatment for gastric cancer is important for a patient's survival. Materials and Methods We analyzed the clinicopathologic data of 214 gastric cancer patients from October 1996 to November 2007 with regard to metachronous second primary cancers. Results Out of 5,778 patients with gastric cancer, metachronous second primary cancers occurred in 214patients. The median age was 61.8 years, the number of male and female patients was 140 (65.4%),74 (34.6%), respectively. The median time to the occurrence of second cancers after diagnosis of the first was 39.2 months (standard deviation, 31.2 months). The most common cancer was colorectal cancer, which occurred in 44 patients (20.6%), and lung cancer in 33 patients (15.4%),hepatocellular carcinoma in 26 patients (12.1%), ovarian cancer in 15 patients (7.0%), cervical cancer in 12 patients (7.0%), breast cancer in 11 patients (5.1%), and esophageal cancer in 11patients (5.1%). The observed/expected (O/E) ratio showed a significant increase in colorectal (1.25), male biliary (1.60), ovarian (8.72), and cervical cancer (3.33) with primary gastric cancer. After five years from diagnosis of gastric cancer, secondary cancer occurred in 50 patients (23.4%), and breast cancer, prostate cancer, laryngeal cancer, lung cancer, and hepatocellular carcinoma were the most frequent. Conclusion The O/E ratio showed a significant increase in colorectal, male biliary, ovarian, and cervical cancer with primary gastric cancer, and second primary cancer as the main cause of death for these patients. A follow-up examination for metachronous double primary cancer is needed in order to improve the survival time in patients with gastric cancer.
참고문헌 (17)
- Watanabe M, "Dual primary gastric and colorectal cancer: Is the prognosis better for synchronous or metachronous?", Am J Clin Oncol (2011)
- Moertel CG, "Multiple carcinomas of the large intestine : a review of the literature and a study of 261 cases", Gastroenterology, 34, pp.85~98 (1958)
- Eom BW, "Synchronous and metachronous cancers in patients with gastric cancer", J Surg Oncol, 98, pp.106~110 (2008)
- Ikeda Y, "Features of second primary cancer in patients with gastric cancer", Oncology, 65, pp.113~117 (2003)
- Maehara Y, "Clinicopathological features of patients who died with second primary cancer after curative resection for gastric cancer", Anticancer Res, 15, pp.1049~1053 (1995)
- Yoshino K, "Multiple primary cancers in the stomach and another organ: frequency and the effects on prognosis", Jpn J Clin Oncol, 15(Suppl 1), pp.183~190 (1985)
- Lundegardh G, "The risk of gastrointestinal and other primary malignant diseases following gastric cancer", Acta Oncol, 30, pp.1~6 (1991)
- Lynge E, "Second cancer following cancer of the digestive system in Denmark, 1943-80", Natl Cancer Inst Monogr, 68, pp.277~308 (1985)
- Lee JH, "Gastric cancer patients at high-risk of having synchronous cancer", World J Gastroenterol, 12, pp.2588~2592 (2006)
- Hiyama T, "Second primary cancer after diagnosis of stomach cancer in Osaka, Japan", Jpn J Cancer Res, 82, pp.762~770 (1991)
- Yang L, "Estimates of cancer incidence in China for 2000 and projections for 2005", Cancer Epidemiol Biomarkers Prev, 14, pp.243~250 (2005)
- Heard A, "Multiple primary cancers of separate organ sites : implications for research and cancer control(Australia)", Cancer Causes Control, 16, pp.475~481 (2005)
- Deakin M, "Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer : studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers", Carcinogenesis, 17, pp.881~884 (1996)
- Knekt P, "Risk of colorectal and other gastro-intestinal cancers after exposure to nitrate, nitrite and N-nitroso compounds : a follow-up study", Int J Cancer, 80, pp.852~856 (1999)
- Kato I, "Second malignancy in stomach cancer patients and its possible risk factors", Jpn J Clin Oncol, 16, pp.373~381 (1986)
- Yun HR, "Double primary malignancy in colorectal cancer patients : MSI is the useful marker for predicting double primary tumors", Int J Colorectal Dis, 24, pp.369~375 (2009)
- Furukawa H, "Treatments for second malignancies after gastrectomy for stomach cancer", Hepatogastroenterology, 43, pp.194~198 (1996)