A Case Report of Paraneoplastic Pemphigus Associated with Esophageal Squamous Cell Carcinoma
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Paraneoplastic pemphigus is an autoimmune blistering and erosive mucocutaneous syndrome associated with underlying neoplasm. It is primarily associated with lymphoproliferative disorders, and uncommonly with malignancies of epithelial origin. We report on a case of a 68-year-old male who presented with whole body bullous and erosive skin lesions. Findings on upper gastrointestinal endoscopy and skin biopsy revealed esophageal squamous cell carcinoma and paraneoplastic pemphigus. Palliative chemotherapy and systemic glucocorticoid were started, however, the patient died of overwhelming sepsis on the ninth day of chemotherapy. This case demonstrates that paraneoplastic pemphigus can occur in esophageal squamous cell carcinoma and could be a cause of morbidity.
Abstract
Paraneoplastic pemphigus is an autoimmune blistering and erosive mucocutaneous syndrome associated with underlying neoplasm. It is primarily associated with lymphoproliferative disorders, and uncommonly with malignancies of epithelial origin. We report on a case of a 68-year-old male who presented with whole body bullous and erosive skin lesions. Findings on upper gastrointestinal endoscopy and skin biopsy revealed esophageal squamous cell carcinoma and paraneoplastic pemphigus. Palliative chemotherapy and systemic glucocorticoid were started, however, the patient died of overwhelming sepsis on the ninth day of chemotherapy. This case demonstrates that paraneoplastic pemphigus can occur in esophageal squamous cell carcinoma and could be a cause of morbidity.
참고문헌 (15)
- Abreu Velez AM, "Diagnosis and treatment of cutaneous paraneoplastic disorders", Dermatol Ther, 23, pp.662~675 (2010)
- Pelosof LC, "Paraneoplastic syndromes: an approach to diagnosis and treatment", Mayo Clin Proc, 85, pp.838~854 (2010)
- Ehst BD, "Cutaneous manifestations of internal malignancy", Curr Probl Surg, 47, pp.384~445 (2010)
- Herzberg JJ, "Cutaneous paraneoplasms in tumors of the gastrointestinal tract and the large gastric glands", Z Gastroenterol, 10, pp.249~256 (1972)
- Kaplan I, "Neoplasms associated with paraneoplastic pemphigus: a review with emphasis on non-hematologic malignancy and oral mucosal manifestations", Oral Oncol, 40, pp.553~562 (2004)
- Sheklakov ND, "Simultaneous pemphigus vulgaris and cancerous tumor of the the esophagus", Sov Med, 29, pp.122~123 (1966)
- Takahashi O, "Esophageal pemphigus vulgaris with carcinoma: postoperative steroid therapy based on pemphigus-related antibodies", Dis Esophagus, 18, pp.413~417 (2005)
- Anhalt GJ, "Paraneoplastic pemphigus: an autoimmune mucocutaneous disease associated with neoplasia", N Engl J Med, 323, pp.1729~1735 (1990)
- Camisa C, "Paraneoplastic pemphigus is a distinct neoplasia- induced autoimmune disease", Arch Dermatol, 129, pp.883~886 (1993)
- Futei Y, "Conformational epitope mapping and IgG subclass distribution of desmoglein 3 in paraneoplastic pemphigus", J Am Acad Dermatol, 49, pp.1023~1028 (2003)
- Seishima, "Antibody titers to desmogleins 1 and 3 in a patient with paraneoplastic pemphigus associated with follicular dendritic cell sarcoma", Arch Dermatol, 140, pp.1500~1503 (2004)
- Cummins DL, "Lichenoid paraneoplastic pemphigus in the absence of detectable antibodies", J Am Acad Dermatol, 56, pp.153~159 (2007)
- Nousari HC, "Immunoablative high-dose cyclophosphamide without stem cell rescue in paraneoplastic pemphigus: report of a case and review of this new therapy for severe autoimmune disease", J Am Acad Dermatol, 40(5 Pt 1), pp.750~754 (1999)
- Barnadas M, "Therapy of paraneoplastic pemphigus with Rituximab: a case report and review of literatur", J Eur Acad Dermatol Venereol, 20, pp.69~74 (2006)
- Schadlow MB, "Using rituximab (anti-CD20 antibody) in a patient with paraneoplastic pemphigus", J Drugs Dermatol, 2, pp.564~567 (2003)