HPV-Related Retroperitoneal Squamous Cell Carcinoma of Unknown Primary: A Case Report
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
A 56-year-old female was referred to our hospital due to a mass measuring 5 cm insize in the left pelvic cavity, which was found incidentally during a health examinationby ultrasonography. Exploratory laparotomy was performed and the mass was locatedat the left retroperitoneal parametrium without invasion of the uterus and ovary. Thepathology report confirmed squamous cell carcinoma. Even after further studies, wedid not find any other primary lesion. Human papillomavirus (HPV) DNA chip test (HPV9G DNA Membrane Kit, Biometrixtechnology Inc.) showed that the surgical specimenwas positive for HPV 18. She received adjuvant chemotherapy and would receiveradiation therapy for the possibility of occult gynecologic cancer. Retroperitoneal squamouscell carcinoma of unknown primary is extremely rare and little is known aboutit. It is reported that HPV may be associated with the disease. Hence, the result ofHPV test could have an impact on finding a suspicious primary lesion and treatmentmodality in this case.
Abstract
A 56-year-old female was referred to our hospital due to a mass measuring 5 cm insize in the left pelvic cavity, which was found incidentally during a health examinationby ultrasonography. Exploratory laparotomy was performed and the mass was locatedat the left retroperitoneal parametrium without invasion of the uterus and ovary. Thepathology report confirmed squamous cell carcinoma. Even after further studies, wedid not find any other primary lesion. Human papillomavirus (HPV) DNA chip test (HPV9G DNA Membrane Kit, Biometrixtechnology Inc.) showed that the surgical specimenwas positive for HPV 18. She received adjuvant chemotherapy and would receiveradiation therapy for the possibility of occult gynecologic cancer. Retroperitoneal squamouscell carcinoma of unknown primary is extremely rare and little is known aboutit. It is reported that HPV may be associated with the disease. Hence, the result ofHPV test could have an impact on finding a suspicious primary lesion and treatmentmodality in this case.
참고문헌 (14)
- 유민지, "Primary squamous cell carcinoma arising from the pelvic retroperitoneum", Obstetrics & Gynecology Science, 55(10), pp.782~786 (2012), 대한산부인과학회[DOI]
- Hofmann U, "Retroperitoneal metastatic squamous cell carcinoma of the tonsil(with elevated beta human chorionic gonadotrophin) : a misdiagnosis as extra-gonadal germ cell tumour", J Laryngol Otol, 120, pp.885~887 (2006)
- Munoz N, "Chapter 1: HPV in the etiology of human cancer", Vaccine, 24(Suppl 3), pp.1~10 (2006)
- Staebler A, "Hormone receptor immunohistochemistry and human papillomavirus in situ hybridization are useful for distinguishing endocervical and endometrial adenocarcinomas", Am J Surg Pathol, 26, pp.998~1006 (2002)
- Clements A, "The presence of human papillomavirus or p16in six cases of retroperitoneal carcinoma", Obstet Gynecol, 116, pp.1042~1046 (2010)
- Capone RB, "Detection and quantitation of human papillomavirus(HPV)DNA in the sera of patients with HPV-associated head and neck squamous cell carcinoma", Clin Cancer Res, 6, pp.4171~4175 (2000)
- Kan CY, "Identification of human papillomavirus DNA gene sequences in human breast cancer", Br J Cancer, 93, pp.946~948 (2005)
- Chen CH, "Optimum treatment for primary squamous cell carcinoma of the pelvic retroperitoneum", J Exp Clin Med, 3, pp.304~306 (2011)
- Boneschi M, "Primary retroperitoneal tumors : treatment modality and prognostic factors", Minerva Chir, 54, pp.763~768 (1999)
- Carabias E, "Primary mucinous cystadenocarcinoma of the retroperitoneum. Report of a case and literature review", Virchows Arch, 426, pp.641~645 (1995)
- Dore R, "Primitive mucinous cystadenocarcinoma of the retroperitoneum : case report and diagnostic considerations", Clin Imaging, 20, pp.129~132 (1996)
- Caruncho M, "Primary retroperitoneal serous cystadenocarcinoma of 'ovarian-type' : US and CT findings", Eur J Radiol, 17, pp.115~116 (1993)
- Ramshankar V, "Human papilloma virus in head and neck cancers-role and relevance in clinical management", Indian J Surg Oncol, 4, pp.59~66 (2013)
- Zandberg DP, "The role of human papillomavirus in nongenital cancers", CA Cancer J Clin, 63, pp.57~81 (2013)