Conventional Cisplatin-Based Combination Chemotherapy Is Effective in the Treatment of Metastatic Spermatocytic Seminoma with Extensive Rhabdomyosarcomatous Transformation
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A 52-year-old man was presented with a huge left testicular mass and palpablecervical lymphadenopathy with retroperitoneal lymph node enlargement on anabdominal computed tomography. A left radical orchiectomy and an ultrasoundguidedneck node biopsy were performed. A pathological examination revealed spermatocyticseminoma with extensive rhabdomyosarcomatous transformation, acondition known to be highly resistant to platinum-based chemotherapy. The patientreceived four cycles of etoposide, ifosfamide and cisplatin (VIP) chemotherapy. Arepeat computed tomography revealed a substantial regression consistent with a partialresponse. Retroperitoneal lymph node dissection was attempted, which revealedrhabdomyosarcoma; however, complete microscopic resection was not achieved. After surgery, the residual abdominal lymph node progressed and salvage paclitaxel,ifosfamide and cisplatin (TIP) chemotherapy was employed, which again achieved apartial response. Here, we present a first case report of a spermatocytic seminomawith extensive rhabdomyosarcomatous transformation and multiple metastaticlymphadenopathies that showed a favorable response to platinum-based systemicchemotherapy.
Abstract
A 52-year-old man was presented with a huge left testicular mass and palpablecervical lymphadenopathy with retroperitoneal lymph node enlargement on anabdominal computed tomography. A left radical orchiectomy and an ultrasoundguidedneck node biopsy were performed. A pathological examination revealed spermatocyticseminoma with extensive rhabdomyosarcomatous transformation, acondition known to be highly resistant to platinum-based chemotherapy. The patientreceived four cycles of etoposide, ifosfamide and cisplatin (VIP) chemotherapy. Arepeat computed tomography revealed a substantial regression consistent with a partialresponse. Retroperitoneal lymph node dissection was attempted, which revealedrhabdomyosarcoma; however, complete microscopic resection was not achieved. After surgery, the residual abdominal lymph node progressed and salvage paclitaxel,ifosfamide and cisplatin (TIP) chemotherapy was employed, which again achieved apartial response. Here, we present a first case report of a spermatocytic seminomawith extensive rhabdomyosarcomatous transformation and multiple metastaticlymphadenopathies that showed a favorable response to platinum-based systemicchemotherapy.
참고문헌 (12)
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