An Unusual Presentation of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma as Diffuse Pulmonary Infiltrates with Spontaneous Regression
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A 57-year-old woman presented with cough and dyspnea for 2 months. Computedtomography of the chest showed diffuse ground-glass opacities in both lungs. Histologicexamination via thoracoscopic lung biopsy revealed atypical lymphoproliferativelesion. Her symptoms and radiologic findings of the chest improved just after lungbiopsy without any treatment. Therefore, she was discharged and monitored at anoutpatient clinic. Two months later, pulmonary mucosa-associated lymphoid tissue(MALT) lymphoma was confirmed by the detection of API2-MALT1 translocation influorescent in situ hybridization analysis. Although the lung lesions resolved spontaneously,she received chemotherapy due to bone marrow involvement in her stagingworkup. Pulmonary MALT lymphoma is rare. Nodular or consolidative patterns are themost frequent radiologic findings. Although the disease has an indolent growth, itrarely resolves without treatment. We report an unusual case of pulmonary MALT lymphomawith diffuse interstitial abnormalities on image and spontaneous regressionon clinical course.
Abstract
A 57-year-old woman presented with cough and dyspnea for 2 months. Computedtomography of the chest showed diffuse ground-glass opacities in both lungs. Histologicexamination via thoracoscopic lung biopsy revealed atypical lymphoproliferativelesion. Her symptoms and radiologic findings of the chest improved just after lungbiopsy without any treatment. Therefore, she was discharged and monitored at anoutpatient clinic. Two months later, pulmonary mucosa-associated lymphoid tissue(MALT) lymphoma was confirmed by the detection of API2-MALT1 translocation influorescent in situ hybridization analysis. Although the lung lesions resolved spontaneously,she received chemotherapy due to bone marrow involvement in her stagingworkup. Pulmonary MALT lymphoma is rare. Nodular or consolidative patterns are themost frequent radiologic findings. Although the disease has an indolent growth, itrarely resolves without treatment. We report an unusual case of pulmonary MALT lymphomawith diffuse interstitial abnormalities on image and spontaneous regressionon clinical course.
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