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Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation for Atypical Teratoid/Rhabdoid Tumor

이은상|이지원|김지혜|정유숙|최영배|신형진|서연림|임도훈|유건희|구홍회|성기웅
대한암학회 (Korean Cancer Association)|2016.10|Cancer Research and Treatment|제48권 제4호|pp. 1408-1419

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키워드

Hematopoietic stem cell transplantationRadiotherapyChemotherapyBrain neoplasms
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초록

Purpose We prospectively evaluated the effectiveness of tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT) in improving the survival of patients with atypical teratoid/rhabdoid tumors while reducing the risks of late adverse effects from radiotherapy (RT). Materials and Methods For young children (< 3 years old), tandem HDCT/auto-SCT was administered after six cycles of induction chemotherapy. RT was deferred until after 3 years of age unless the tumor showed relapse or progression. For older patients (> 3 years old), RT including reduceddose craniospinal RT (23.4 or 30.6 Gy) was administered either after two cycles of induction chemotherapy or after surgery, and tandem HDCT/auto-SCT was administered after six cycles of induction chemotherapy. Results A total of 13 patients (five young and eight older) were enrolled from November 2004 to June 2012. Eight patients, including all five young patients, had metastatic disease at diagnosis. Six patients (four young and two older) experienced progression before initiation of RT, and seven were able to proceed to HDCT/auto-SCT without progression during induction treatment. Three of six patients who experienced progression during induction treatment underwent HDCT/auto-SCT as salvage treatment. All five young patients died from disease progression. However, four of the eight older patients remain progression-free with a median follow-up period of 64 months (range, 39 to 108 months). Treatment-related late toxicities were acceptable. Conclusion The required dose of craniospinal RT might be reduced in older patients if the intensity of chemotherapy is increased. However, early administration of RT should be considered to prevent early progression in young patients.

Abstract

Purpose We prospectively evaluated the effectiveness of tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT) in improving the survival of patients with atypical teratoid/rhabdoid tumors while reducing the risks of late adverse effects from radiotherapy (RT). Materials and Methods For young children (< 3 years old), tandem HDCT/auto-SCT was administered after six cycles of induction chemotherapy. RT was deferred until after 3 years of age unless the tumor showed relapse or progression. For older patients (> 3 years old), RT including reduceddose craniospinal RT (23.4 or 30.6 Gy) was administered either after two cycles of induction chemotherapy or after surgery, and tandem HDCT/auto-SCT was administered after six cycles of induction chemotherapy. Results A total of 13 patients (five young and eight older) were enrolled from November 2004 to June 2012. Eight patients, including all five young patients, had metastatic disease at diagnosis. Six patients (four young and two older) experienced progression before initiation of RT, and seven were able to proceed to HDCT/auto-SCT without progression during induction treatment. Three of six patients who experienced progression during induction treatment underwent HDCT/auto-SCT as salvage treatment. All five young patients died from disease progression. However, four of the eight older patients remain progression-free with a median follow-up period of 64 months (range, 39 to 108 months). Treatment-related late toxicities were acceptable. Conclusion The required dose of craniospinal RT might be reduced in older patients if the intensity of chemotherapy is increased. However, early administration of RT should be considered to prevent early progression in young patients.

참고문헌 (25)

  1. Hilden JM, "Central nervous system atypical teratoid", rhabdoid tumor : results of therapy in children enrolled in a registry, 2004, pp.22, 2877~2884
  2. Tekautz TM, "Atypical teratoid", rhabdoid tumors(ATRT) : improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy, 2005, pp.23, 1491~1499
  3. Bikowska B, "Atypical teratoid", rhabdoid tumor : short clinical description and insight into possible mechanism of the disease, 2011, pp.18, 813~818
  4. von Hoff K, "Frequency, riskfactors and survival of children with atypical teratoid rhabdoid tumors(AT", RT)of the CNS diagnosed between 1988and 2004, and registered to the German HIT database, 2011, pp.57, 978~985
  5. Athale UH, "Childhood atypical teratoid rhabdoid tumor of the central nervous system : a meta-analysis of observational studies", J Pediatr Hematol Oncol, 31, pp.651~663 (2009)
  6. Lafay-Cousin L, "Central nervous system atypical teratoid rhabdoid tumours : the Canadian Paediatric Brain Tumour Consortium experience", Eur J Cancer, 48, pp.353~359 (2012)
  7. Mulhern RK, "Late neurocognitive sequelae in survivors of brain tumours in childhood", Lancet Oncol, 5, pp.399~408 (2004)
  8. Matthay KK, "Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid : a children's oncology group study", J Clin Oncol, 27, pp.1007~1013 (2009)
  9. Fangusaro J, "Intensive chemotherapy followed by consolidative myeloablative chemotherapy with autologous hematopoietic cell rescue(AuHCR)in young children with newly diagnosed supratentorial primitive neuroectodermal tumors(sPNETs) : report of the Head Start I and II experience", Pediatr Blood Cancer, 50, pp.312~318 (2008)
  10. Mason WP, "Intensive chemotherapy and bone marrow rescue for young children with newly diagnosed malignant brain tumors", J Clin Oncol, 16, pp.210~221 (1998)
  11. Gardner SL, "Intensive induction chemotherapy followed by high dose chemotherapy with autologous hematopoietic progenitor cell rescue in young children newly diagnosed with central nervous system atypical teratoid rhabdoid tumors", Pediatr Blood Cancer, 51, pp.235~240 (2008)
  12. Sung KW, "High-dose chemotherapy and autologous stem cell rescue in children with newly diagnosed high-risk or relapsed medulloblastoma or supratentorial primitive neuroectodermal tumor", Pediatr Blood Cancer, 48, pp.408~415 (2007)
  13. Gajjar A, "Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma(St Jude Medulloblastoma-96) : long-term results from a prospective, multicentre trial", Lancet Oncol, 7, pp.813~820 (2006)
  14. Sung KW, "Tandem high-dose chemotherapy and auto-SCT for malignant brain tumors in children under 3 years of age", Bone Marrow Transplant, 48, pp.932~938 (2013)
  15. Sung KW, "Reduced-dose craniospinal radiotherapy followed by tandem high-dose chemotherapy and autologous stem cell transplantation in patients with high-risk medulloblastoma", Neuro Oncol, 15, pp.352~359 (2013)
  16. Laurent JP, "A classification system for primitive neuroectodermal tumors(medulloblastoma)of the posterior fossa", Cancer, 56, pp.1807~1809 (1985)
  17. Finkelstein-Shechter T, "Atypical teratoid or rhabdoid tumors:improved outcome with high-dose chemotherapy", J Pediatr Hematol Oncol, 32, pp.182~186 (2010)
  18. 박은실, "Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation in Young Children with Atypical Teratoid", Rhabdoid Tumor of the Central Nervous System, 2012, pp.27(2), 135~140[DOI]
  19. Zaky W, "Intensive induction chemotherapy followed by myeloablative chemotherapy with autologous hematopoietic progenitor cell rescue for young children newly-diagnosed with central nervous system atypical teratoid", rhabdoid tumors : the Head Start III experience, 2014, pp.61, 95~101
  20. Chi SN, "Intensive multimodality treatment for children with newly diagnosed CNS atypical teratoid rhabdoid tumor", J Clin Oncol, 27, pp.385~389 (2009)
  21. Lee SH, "Toxicity of tandem high-dose chemotherapy and autologous stem cell transplantation using carboplatin-thiotepa-etoposide and cyclophosphamide-melphalan regimens for malignant brain tumors in children and young adults", J Neurooncol, 120, pp.507~513 (2014)
  22. Duffner PK, "Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors", N Engl J Med, 328, pp.1725~1731 (1993)
  23. Grill J, "Treatment of medulloblastoma with postoperative chemotherapy alone : an SFOP prospective trial in young children", Lancet Oncol, 6, pp.573~580 (2005)
  24. Pai Panandiker AS, "Sequencing of local therapy affects the pattern of treatment failure and survival in children with atypical teratoid rhabdoid tumors of the central nervous system", Int J Radiat Oncol Biol Phys, 82, pp.1756~1763 (2012)
  25. Chen YW, "Impact of radiotherapy for pediatric CNS atypical teratoid", rhabdoid tumor(single institute experience), 2006, pp.64, 1038~1043

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