만성통증 환자에서 Tramadol/Acetaminophen 복합제제의 치료 효과
Effect of Tramadol/Acetaminophen Combination Tablets in the Treatment of Chronic Pain
1
조회
0
다운로드
0
인용
0
참고문헌
초록
Abstract
Background: The aim of this study was to evaluate the efficacy of a tramadol/acetaminophen combination tablet in chronic pain management.Methods: Two hundred fifty five adult patients, suffering from chronic pain, were administered tramadol/acetaminophen combination tablets for at least 4 weeks. The analgesic effect from the start to the finish of the study was evaluated by a numeric rating scale (NRS, from 0 to 10). The pain relief score was also recorded (initial NRS-final NRS), which was allocated as follows: no change (0 or aggravation), moderate (1 2), notable (3 4) or significant pain relief (5 or more). The usefulness of the tramadol/acetaminophen combination tablet was rated according to the NRS, the pain relief score, the appearance of side effect and the patient's response, and categorized as not useful, useful or very useful. Results: The mean NRS score decreased from 6.1 to 3.5. The pain relief scores were no relief, moderate relief notable relief, significant relief and not assessed in 17, 108, 95, 23 and 3, respectively. Side effects developed in only 5.7% of the 246 patients.Conclusions: It was concluded that tramadol/acetaminophen combination tablet therapy had an additive effect in the treatment of chronic pain management when combined with other analgesics.
참고문헌 (15)
- "TRAMAP-ANAG-006 SANDY Group: Tramadol", acetaminophen combination tablets and codeine, pp.2001, 23[DOI]
- "Discovery of "self- synergistic" spinal", supraspinal antinociception produced by acetaminophen (paracetamol)., 2000, pp.295, 291~294
- "Acetaminophen blocks spinal hyperalgesia induced by NMDA and substance P", 57, pp.259~64 (1994)
- "Evidence of a central antinociceptive effect of paracetamol involving spinal 5HT3 receptors", 6, pp.1546~1548 (1995)
- "Randomized,double-blind,placebo-controlled comparison of the analgesic efficacy of oxycodone 10 mg", acetaminophen 325 mg versus controlled-release oxycodone 20 mg in postsurgical pain, 2003, pp.43, 296~304
- "Combination analgesics", 77, pp.38~53 (1984)
- "Testing for synergism over a range of fixed ratio drug combinations; replacing the isobolologram.", 58, pp.23~28 (1996)
- "Tramadol and acetaminophen tablets for dental pain", 48, pp.79~81 (2001)
- "Cancer pain relief, with a guide to opioid availability" (1996), World Health Organization.
- "A postmarketing surveillance program to monitor Ultram(tramadol hydrochloride) abuse in the United States", 57, pp.7~22
- "Diagnosis and management of aute low back pain", 61, pp.1779~1786 (2000)
- "Efficacy of tramadol in treatment of chronic low back pain", 27, pp.772~778 (2000)
- "Double-blind randomized trial of tramadol for the treatment of the pain of diabetic neuropathy", 50, pp.1842~1846 (1998)
- "Efficacy and safety of combination tramadol and acetaminophen tablets for the treatment of pain : multicenter, outpatient, randomized, double-blind, placebo- controlled, parallel-group, add-on study", 24, pp.282~297 (2002)
- "Protocol CAPSS-112 Study GroupTramadol", acetaminophen combination tablets for the treatment : a multicenter, randomized, double-blind, placebo-controlled outpatient study, 2003, pp.25, 1123~1141