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하악 2급 치근 이개부 병소에서 키토산 나노 차폐막을 이용한 치주조직 재생의 임상적 효과에 관한 비교 연구

A comparative study of the clinical effects of chitosan nanofiber membrane in the treatment of mandibular class Ⅱ furcation defects

임성빈|정진형|김정빈|홍기석|최한선|정임
대한치주과학회 (The Korean Academy Of Periodontology)|2005.09|Journal of Periodontal & Implant Science|제35권 제3호|pp. 703-718

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참고문헌

주제분류치의학

초록

Abstract

The purpose of this study was to evaluate the clinical efficacy of guided tissue regenera- tion(GTR) technique using chitosan nanofiber membrane and to compare it to the clinical efficacy following GTR using PLA/PLGA(copolymer of polylactic acid and polylacticglycolic acid) membrane in mandibular class II furcation defects in human. The chitosan nanofiber membra- nes were applied to the mandibular class II furcation defects of 13 patients(test group) and PLA/PLGA membranes were applied to those of 11 patients(control group). Probing pocket depth, clinical attachment level, gingival recession, plaque index and gingi- val index were measured at baseline and 3 months postoperatively. Vertical and horizontal furcation defect depth were measured at surgery. Both groups were statistically analyzed by Wilcoxon signed Ranks Test and Mann-Whitney Test using SPSS program. The results were as follows: 1. Probing pocket depth, clinical attachment loss and gingival index were significantly re- duced at 3 months postoperatively compared to values of baseline in both groups(p<0.05). 2. Gingival recession and plaque index were not significantly decreased at 3 months postoperatively compared to values of baseline in both groups. 3. No significant difference between two groups could be detected with regard to changes of probing pocket depth, gingival recession, clinical attachment level, plaque index and gingival index at 3 months postoperatively. In conclusion, chitosan nanofiber membrane is effective in the treatment of human mandi- bular class II furcation defects and a longer period study is needed to fully evaluate the outcomes.

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