Increasing Incidence of B-Cell Non-Hodgkin Lymphoma and Occurrence of Second Primary Malignancies in South Korea: 10-Year Follow-up Using the Korean National Health Information Database
2
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Purpose The epidemiology of B-cell non-Hodgkin lymphoma (BNHL) in Asia is not well described, and rates of second primary malignancies (SPM) in these patients are not known. We aimed to describe temporal changes in BNHL epidemiology and SPM incidence in Korea. Materials and Methods A retrospective cohort study used claims data from the National Health Insurance Service that provides universal healthcare coverage in Korea. Newly diagnosed patients aged at least 19 years with a confirmed diagnosis of one of six BNHL subtypes (diffuse large cell B-cell lymphoma [DLBCL], small lymphocytic and chronic lymphocytic [CLL/SLL], follicular lymphoma [FL], mantle cell lymphoma [MCL], marginal zone lymphoma [MZL], and lymphoplasmacytic lymphoma/Waldenström’s macroglobulinemia [WM]) during the period 2006-2015 were enrolled and followed up until death, dis-enrolment, or study end, whichever occurred first. Patients with pre-existing primary cancers prior to the diagnosis of BNHL were excluded. Results A total of 19,500 patients with newly diagnosed BNHL were identified out of 27,866 with non-Hodgkin lymphoma (NHL). DLBCL was the most frequently diagnosed subtype (41.9%-48.4% of NHL patients annually, 2011-2015). Standardized incidence of the six subtypes studied per 100,000 population increased from 5.74 in 2011 to 6.96 in 2015, with most increases in DLBCL, FL, and MZL. The incidence (95% confidence interval) of SPM per 100 person-years was 2.74 (2.26-3.29) for CLL/SLL, 2.43 (1.57-3.58) for MCL, 2.41 (2.10-2.76) for MZL, 2.23 (2.07-2.40) for DLBCL, 1.97 (1.61-2.38) for FL, and 1.41 (0.69-2.59) for WM. Conclusion BNHL has been increasingly diagnosed in Korea. High rates of SPM highlight the need for continued close monitoring to ensure early diagnosis and treatment.
Abstract
Purpose The epidemiology of B-cell non-Hodgkin lymphoma (BNHL) in Asia is not well described, and rates of second primary malignancies (SPM) in these patients are not known. We aimed to describe temporal changes in BNHL epidemiology and SPM incidence in Korea. Materials and Methods A retrospective cohort study used claims data from the National Health Insurance Service that provides universal healthcare coverage in Korea. Newly diagnosed patients aged at least 19 years with a confirmed diagnosis of one of six BNHL subtypes (diffuse large cell B-cell lymphoma [DLBCL], small lymphocytic and chronic lymphocytic [CLL/SLL], follicular lymphoma [FL], mantle cell lymphoma [MCL], marginal zone lymphoma [MZL], and lymphoplasmacytic lymphoma/Waldenström’s macroglobulinemia [WM]) during the period 2006-2015 were enrolled and followed up until death, dis-enrolment, or study end, whichever occurred first. Patients with pre-existing primary cancers prior to the diagnosis of BNHL were excluded. Results A total of 19,500 patients with newly diagnosed BNHL were identified out of 27,866 with non-Hodgkin lymphoma (NHL). DLBCL was the most frequently diagnosed subtype (41.9%-48.4% of NHL patients annually, 2011-2015). Standardized incidence of the six subtypes studied per 100,000 population increased from 5.74 in 2011 to 6.96 in 2015, with most increases in DLBCL, FL, and MZL. The incidence (95% confidence interval) of SPM per 100 person-years was 2.74 (2.26-3.29) for CLL/SLL, 2.43 (1.57-3.58) for MCL, 2.41 (2.10-2.76) for MZL, 2.23 (2.07-2.40) for DLBCL, 1.97 (1.61-2.38) for FL, and 1.41 (0.69-2.59) for WM. Conclusion BNHL has been increasingly diagnosed in Korea. High rates of SPM highlight the need for continued close monitoring to ensure early diagnosis and treatment.
참고문헌 (26)
- Armitage JO, "Non-Hodgkin lymphoma", Lancet, 390, pp.298~310 (2017)
- 이혜원, "Nationwide Statistical Analysis of Lymphoid Malignancies in Korea", Cancer Research and Treatment, 50(1), pp.222~238 (2018), 대한암학회
- Morton LM, "Etiologic heterogeneity among non-Hodgkin lymphoma subtypes : the InterLymph Non-Hodgkin Lymphoma Subtypes Project", J Natl Cancer Inst Monogr, 2014, pp.130~144 (2014)
- Feugier P, "A review of rituximab, the first anti-CD20 monoclonal antibody used in the treatment of B non-Hodgkin’s lymphomas", Future Oncol, 11, pp.1327~1342 (2015)
- Pirani M, "Risk for second malignancies in non-Hodgkin’s lymphoma survivors : a meta-analysis", Ann Oncol, 22, pp.1845~1858 (2011)
- Tward JD, "The risk of secondary malignancies over 30 years after the treatment of non-Hodgkin lymphoma", Cancer, 107, pp.108~115 (2006)
- Perry AM, "Non-Hodgkin lymphoma in the developing world : review of 4539 cases from the International Non-Hodgkin Lymphoma Classification Project", Haematologica, 101, pp.1244~1250 (2016)
- Yoon SO, "Distribution of lymphoid neoplasms in the Republic of Korea : analysis of 5318 cases according to the World Health Organization classification", Am J Hematol, 85, pp.760~764 (2010)
- Chuang SS, "Lymphoma in Taiwan : review of 1347 neoplasms from a single institution according to the 2016 Revision of the World Health Organization Classification", J Formos Med Assoc, 116, pp.620~625 (2017)
- Bassig BA, "Genetic susceptibility to diffuse large B-cell lymphoma in a pooled study of three Eastern Asian populations", Eur J Haematol, 95, pp.442~448 (2015)
- Cerhan JR, "Familial predisposition and genetic risk factors for lymphoma", Blood, 126, pp.2265~2273 (2015)
- Biagi JJ, "Insights into the molecular pathogenesis of follicular lymphoma arising from analysis of geographic variation", Blood, 99, pp.4265~4275 (2002)
- 김지애, "Towards Actualizing the Value Potential of Korea Health Insurance Review and Assessment (HIRA) Data as a Resource for Health Research: Strengths, Limitations, Applications, and Strategies for Optimal Use of HIRA Data", Journal of Korean Medical Science, 32(5), pp.718~728 (2017), 대한의학회
- Seong SC, "Data resource profile : the National Health Information Database of the National Health Insurance Service in South Korea", Int J Epidemiol, 46, pp.799~800 (2017)
- Moertel CG, "Multiple primary malignant neoplasms. I. Introduction and presentation of data", Cancer, 14, pp.221~230 (1961)
- LeMieux MH, "Risk of second malignancies in patients with early-stage classical Hodgkin’s lymphoma treated in a modern era", Cancer Med, 4, pp.513~518 (2015)
- Engelhardt M, "Large registry analysis to accurately define second malignancy rates and risks in a well-characterized cohort of 744 consecutive multiple myeloma patients followed-up for 25 years", Haematologica, 100, pp.1340~1349 (2015)
- Castillo JJ, "Secondary malignancies in patients with multiple myeloma, Waldenstrom macroglobulinemia and monoclonal gammopathy of undetermined significance", Leuk Lymphoma, 58, pp.773~780 (2017)
- Giri S, "Risk of second primary malignancies in patients with follicular lymphoma : a United States population-based study", Clin Lymphoma Myeloma Leuk, 17, pp.569~574 (2017)
- Shah BK, "Second primary malignancies in mantle cell lymphoma : a US population-based study", Anticancer Res, 35, pp.3437~3440 (2015)
- Tao L, "Subsequent primary malignancies after diffuse large B-cell lymphoma in the modern treatment era", Br J Haematol, 178, pp.72~80 (2017)
- 정규원, "Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2015", Cancer Research and Treatment, 50(2), pp.303~316 (2018), 대한암학회
- "Korea Central Cancer Registry profile page" (2020)[URL]
- Sant M, "Incidence of hematologic malignancies in Europe by morphologic subtype : results of the HAEMACARE project", Blood, 116, pp.3724~3734 (2010)
- Ye X, "Long-term time trends in incidence, survival and mortality of lymphomas by subtype among adults in Manitoba, Canada : a population-based study using cancer registry data", BMJ Open, 7, pp.e015106~ (2017)
- Morton LM, "Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001", Blood, 107, pp.265~276 (2006)