Spinal Gap Junction Channels in Neuropathic Pain
1
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Damage to peripheral nerves or the spinal cord is often accompanied by neuropathic pain, which is a complex, chronic pain state. Increasing evidence indicates that alterations in the expression and activity of gap junction channels in the spinal cord are involved in the development of neuropathic pain. Thus, this review briefly summarizes evidence that regulation of the expression, coupling, and activity of spinal gap junction channels modulates pain signals in neuropathic pain states induced by peripheral nerve or spinal cord injury. We particularly focus on connexin 43 and pannexin 1 because their regulation vastly attenuates symptoms of neuropathic pain. We hope that the study of gap junction channels eventually leads to the development of a suitable treatment tool for patients with neuropathic pain. (Korean J Pain 2015; 28: 231-235)
Abstract
Damage to peripheral nerves or the spinal cord is often accompanied by neuropathic pain, which is a complex, chronic pain state. Increasing evidence indicates that alterations in the expression and activity of gap junction channels in the spinal cord are involved in the development of neuropathic pain. Thus, this review briefly summarizes evidence that regulation of the expression, coupling, and activity of spinal gap junction channels modulates pain signals in neuropathic pain states induced by peripheral nerve or spinal cord injury. We particularly focus on connexin 43 and pannexin 1 because their regulation vastly attenuates symptoms of neuropathic pain. We hope that the study of gap junction channels eventually leads to the development of a suitable treatment tool for patients with neuropathic pain. (Korean J Pain 2015; 28: 231-235)
참고문헌 (39)
- Scholz J, "Can we conquer pain?", Nat Neurosci, 5, pp.1062~1067 (2002)
- Scholz J, "The neuropathic pain triad: neurons, immune cells and glia", Nat Neurosci, 10, pp.1361~1368 (2007)
- Shubayev VI, "TNFalpha-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve", Mol Cell Neurosci, 31, pp.407~415 (2006)
- Bethea JR, "Spinal cord injury-induced inflammation : a dual-edged sword", Prog Brain Res, 128, pp.33~42 (2000)
- Farahani R, "Alterations in metabolism and gap junction expression may determine the role of astrocytes as"good samaritans"or executioners", Glia, 50, pp.351~361 (2005)
- Faulkner JR, "Reactive astrocytes protect tissue and preserve function after spinal cord injury", J Neurosci, 24, pp.2143~2155 (2004)
- Tsuda M, "P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury", Nature, 424, pp.778~783 (2003)
- Gwak YS, "Spatial and temporal activation of spinal glial cells : role of gliopathy in central neuropathic pain following spinal cord injury in rats", Exp Neurol, 234, pp.362~372 (2012)
- Wang X, "P2X7 receptor inhibition improves recovery after spinal cord injury", Nat Med, 10, pp.821~827 (2004)
- Peng W, "Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury", Proc Natl Acad Sci U S A, 106, pp.12489~12493 (2009)
- Springer JE, "Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury", Nat Med, 5, pp.943~946 (1999)
- Collo G, "Tissue distribution of the P2X7 receptor", Neuropharmacology, 36, pp.1277~1283 (1997)
- Kawasaki Y, "Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factoralpha in regulating synaptic and neuronal activity in the superficial spinal cord", J Neurosci, 28, pp.5189~5194 (2008)
- Cotrina ML, "Physiological and pathological functions of P2X7 receptor in the spinal cord", Purinergic Signal, 5, pp.223~232 (2009)
- Reyes EP, "Cxs and Panx-hemichannels in peripheral and central chemosensing in mammals", Front Cell Neurosci, 8, pp.123~ (2014)
- Takeuchi H, "Gap junctions and hemichannels composed of connexins : potential therapeutic targets for neurodegenerative diseases", Front Cell Neurosci, 8, pp.189~ (2014)
- Goldberg GS, "Selective transfer of endogenous metabolites through gap junctions composed of different connexins", Nat Cell Biol, 1, pp.457~459 (1999)
- De Vuyst E, "Connexin hemichannels and gap junction channels are differentially influenced by lipopolysaccharide and basic fibroblast growth factor", Mol Biol Cell, 18, pp.34~46 (2007)
- Retamal MA, "Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia", J Neurosci, 27, pp.13781~13792 (2007)
- Laird DW, "The gap junction proteome and its relationship to disease", Trends Cell Biol, 20, pp.92~101 (2010)
- Giaume C, "Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles.", Front Pharmacol, 4, pp.88~ (2013)
- Stout CE, "Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels", J Biol Chem, 277, pp.10482~10488 (2002)
- Ye ZC, "Functional hemichannels in astrocytes : a novel mechanism of glutamate release", J Neurosci, 23, pp.3588~3596 (2003)
- Chen G, "Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice", Brain, 137, pp.2193~2209 (2014)
- Wu A, "Role of gap junctions in chronic pain", J Neurosci Res, 90, pp.337~345 (2012)
- Rozental R, "Gap junctions in the nervous system", Brain Res Brain Res Rev, 32, pp.11~15 (2000)
- Spataro LE, "Spinal gap junctions : potential involvement in pain facilitation", J Pain, 5, pp.392~405 (2004)
- Roh DH, "Intrathecal injection of carbenoxolone, a gap junction decoupler, attenuates the induction of below-level neuropathic pain after spinal cord injury in rats", Exp Neurol, 224, pp.123~132 (2010)
- Rohlmann A, "Astrocytes as rapid sensors of peripheral axotomy in the facial nucleus of rats", Neuroreport, 5, pp.409~412 (1994)
- Ochalski PA, "Connexin-43 in rat spinal cord : localization in astrocytes and identification of heterotypic astro-oligodendrocytic gap junctions", Neuroscience, 76, pp.931~945 (1997)
- Theriault E, "Connexin43 and astrocytic gap junctions in the rat spinal cord after acute compression injury", J Comp Neurol, 382, pp.199~214 (1997)
- Cronin M, "Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury", Mol Cell Neurosci, 39, pp.152~160 (2008)
- Chen MJ, "Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury", Glia, 60, pp.1660~1670 (2012)
- O'Carroll SJ, "Connexin 43 mimetic peptides reduce swelling, astrogliosis, and neuronal cell death after spinal cord injury.", Cell Commun Adhes, 15, pp.27~42 (2008)
- Huang C, "Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury", J Neurosci, 32, pp.3333~3338 (2012)
- Xu Q, "Suppression of spinal connexin 43 expression attenuates mechanical hypersensitivity in rats after an L5 spinal nerve injury", Neurosci Lett, 566, pp.194~199 (2014)
- Sandilos JK, "Physiological mechanisms for the modulation of pannexin 1 channel activity", J Physiol, 590, pp.6257~6266 (2012)
- Bao L, "Pannexin membrane channels are mechanosensitive conduits for ATP", FEBS Lett, 572, pp.65~68 (2004)
- Bravo D, "Pannexin 1 : a novel participant in neuropathic pain signaling in the rat spinal cord", Pain, 155, pp.2108~2115 (2014)
