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Impact of iron deficiency anemia on chronic periodontitis and superoxide dismutase activity: a cross-sectional study

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Purpose: Both chronic periodontitis (CP) and iron deficiency anemia (IDA) induce oxidativestress in the body and cause an imbalance between reactive oxygen species and antioxidants,such as superoxide dismutase (SOD). This study explored the SOD enzyme activity ofsaliva and serum in CP patients with and without IDA and analyzed the impact of IDA on CP. Methods: A total of 82 patients were divided into four groups: control group (CG, 22), periodontallyhealthy IDA patients (IDA-PH, 20), CP patients (CP, 20), and IDA patients with CP(IDA-CP, 20). After clinical measurements and samplings, serum and salivary SOD levels weredetermined using an SOD assay kit. Results: IDA-CP patients exhibited a higher gingival index, bleeding on probing, probingpocket depth, and percentage (%) of sites with a clinical attachment loss (CAL) of ≥6 mm(P<0.008) than CP patients. The mean salivary and serum SOD levels were significantly lowerin the IDA-PH, CP, and IDA-CP patients than in the CG group (P<0.008). A significantpositive correlation between salivary and serum SOD activity was observed in IDA (P<0.05). Furthermore, serum and salivary SOD levels were significantly and negatively correlated withall periodontal parameters including the percentage of sites with CAL of 4–5 and ≥6 mm(P<0.05) except the significant correlation between salivary SOD activity and mean CAL andthe percentage of sites with CAL of 4–5 mm (P>0.05) in these patients. Conclusions: Within the limits of this study, it may be suggested that IDA patients withchronic periodontitis have more periodontal breakdowns than patients with chronic periodontitis. Serum and salivary SOD activity levels were lower in the IDA-PH, CP and IDA-CPgroups than in the CG. Iron deficiency anemia influenced the serum SOD activity but did notseem to affect the salivary SOD activity in these patients.

Abstract

Purpose: Both chronic periodontitis (CP) and iron deficiency anemia (IDA) induce oxidativestress in the body and cause an imbalance between reactive oxygen species and antioxidants,such as superoxide dismutase (SOD). This study explored the SOD enzyme activity ofsaliva and serum in CP patients with and without IDA and analyzed the impact of IDA on CP. Methods: A total of 82 patients were divided into four groups: control group (CG, 22), periodontallyhealthy IDA patients (IDA-PH, 20), CP patients (CP, 20), and IDA patients with CP(IDA-CP, 20). After clinical measurements and samplings, serum and salivary SOD levels weredetermined using an SOD assay kit. Results: IDA-CP patients exhibited a higher gingival index, bleeding on probing, probingpocket depth, and percentage (%) of sites with a clinical attachment loss (CAL) of ≥6 mm(P<0.008) than CP patients. The mean salivary and serum SOD levels were significantly lowerin the IDA-PH, CP, and IDA-CP patients than in the CG group (P<0.008). A significantpositive correlation between salivary and serum SOD activity was observed in IDA (P<0.05). Furthermore, serum and salivary SOD levels were significantly and negatively correlated withall periodontal parameters including the percentage of sites with CAL of 4–5 and ≥6 mm(P<0.05) except the significant correlation between salivary SOD activity and mean CAL andthe percentage of sites with CAL of 4–5 mm (P>0.05) in these patients. Conclusions: Within the limits of this study, it may be suggested that IDA patients withchronic periodontitis have more periodontal breakdowns than patients with chronic periodontitis. Serum and salivary SOD activity levels were lower in the IDA-PH, CP and IDA-CPgroups than in the CG. Iron deficiency anemia influenced the serum SOD activity but did notseem to affect the salivary SOD activity in these patients.

참고문헌 (39)

  1. Sculley DV, "Salivary antioxidants and periodontal disease status", Proc Nutr Soc, 61, pp.137~143 (2002)
  2. Canakci CF, "Reactive oxygen species and human inflammatory periodontal diseases", Biochemistry (Mosc), 70, pp.619~628 (2005)
  3. Ozmeric N, "Advances in periodontal disease markers", Clin Chim Acta, 343, pp.1~16 (2004)
  4. Halliwell B, "The antioxidants of human extracellular fluids", Arch Biochem Biophys, 280, pp.1~8 (1990)
  5. McCord JM, "Human disease, free radicals, and the oxidant", antioxidant balance, 1993, pp.26, 351~357
  6. Fridovich I, "Superoxide anion radical (O2-.), superoxide dismutases, and related matters", J Biol Chem, 272, pp.18515~18517 (1997)
  7. Mapp PI, "Hypoxia, oxidative stress and rheumatoid arthritis", Br Med Bull, 51, pp.419~436 (1995)
  8. Macnee W, "Oxidants and antioxidants as therapeutic targets in chronic obstructive pulmonary disease", Am J Respir Crit Care Med, 160(5 Pt 2), pp.S58~S65 (1999)
  9. Elbim C, "Redox and activation status of monocytes from human immunodeficiency virus-infected patients: relationship with viral load", J Virol, 73, pp.4561~4566 (1999)
  10. Halliwell B, "The role of oxygen radicals in human disease, with particular reference to the vascular system", Haemostasis, 23(Suppl 1), pp.118~126 (1993)
  11. Toxqui L, "Iron deficiency and overload. Implications in oxidative stress and cardiovascular health", Nutr Hosp, 25, pp.350~365 (2010)
  12. Lainson PA, "Anemia, a systemic cause of periodontal disease?", J Periodontol, 39, pp.35~38 (1968)
  13. Chapple IL, "Compromised GCF total antioxidant capacity in periodontitis: cause or effect?", J Clin Periodontol, 34, pp.103~110 (2007)
  14. Page RC, "Case definitions for use in population-based surveillance of periodontitis", J Periodontol, 78(7 Suppl), pp.1387~1399 (2007)
  15. Adamson JW, "Harrison’s principle of internal medicine. Vol 1", pp.844~861 (2012), McGraw Hill
  16. Loe H, "Periodontal disease in pregnancy. I. Prevalence and severity", Acta Odontol Scand, 21, pp.533~551 (1963)
  17. Silness J, "Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condtion", Acta Odontol Scand, 22, pp.121~135 (1964)
  18. Tamaki N, "Short-term effects of non-surgical periodontal treatment on plasma level of reactive oxygen metabolites in patients with chronic periodontitis", J Periodontol, 80, pp.901~906 (2009)
  19. Enhos S, "Relationship between iron-deficiency anemia and periodontal status in female patients", J Periodontol, 80, pp.1750~1755 (2009)
  20. 김상철, "Antioxidant profile of whole saliva after scaling and root planing in periodontal disease", Journal of Periodontal & Implant Science, 40(4), pp.164~171 (2010), 대한치주과학회
  21. Baltacioglu E, "Total antioxidant capacity and superoxide dismutase activity levels in serum and gingival crevicular fluid in post-menopausal women with chronic periodontitis", J Clin Periodontol, 33, pp.385~392 (2006)
  22. Canakci V, "Total antioxidant capacity and antioxidant enzymes in serum, saliva, and gingival crevicular fluid of preeclamptic women with and without periodontal disease", J Periodontol, 78, pp.1602~1611 (2007)
  23. Akalin FA, "Total antioxidant capacity and superoxide dismutase activity levels in serum and gingival crevicular fluid in pregnant women with chronic periodontitis", J Periodontol, 80, pp.457~467 (2009)
  24. Wei D, "Lipid peroxidation levels, total oxidant status and superoxide dismutase in serum, saliva and gingival crevicular fluid in chronic periodontitis patients before and after periodontal therapy", Aust Dent J, 55, pp.70~78 (2010)
  25. Guarnieri C, "Enhanced superoxide production with no change of the antioxidant activity in gingival fluid of patients with chronic adult periodontitis", Free Radic Res Commun, 15, pp.11~16 (1991)
  26. Matthews JB, "Hyperactivity and reactivity of peripheral blood neutrophils in chronic periodontitis", Clin Exp Immunol, 147, pp.255~264 (2007)
  27. Amirkhizi F, "Assessment of lipid peroxidation and activities of erythrocyte cytoprotective enzymes in women with iron deficiency anemia", J Res Med Sci, 13, pp.248~254 (2008)
  28. Isler M, "Superoxide dismutase and glutathione peroxidase in erythrocytes of patients with iron deficiency anemia: effects of different treatment modalities", Croat Med J, 43, pp.16~19 (2002)
  29. Kurtoglu E, "Effect of iron supplementation on oxidative stress and antioxidant status in iron-deficiency anemia", Biol Trace Elem Res, 96, pp.117~123 (2003)
  30. Acharya J, "Red cell lipid peroxidation and antioxidant enzymes in iron deficiency", Eur J Haematol, 47, pp.287~291 (1991)
  31. Hafez FM, "Red blood cells superoxide dismutase activity in iron deficiency anemia", Alex J Ped, 13, pp.439~442 (1999)
  32. Rifkind JM, "Oxygen transport to tissue. Vol 16", pp.345~351 (1994), Plenum Press
  33. Ramamurthy NS, "Reactive oxygen species activate and tetracyclines inhibit rat osteoblast collagenase", J Bone Miner Res, 8, pp.1247~1253 (1993)
  34. Shabani F, "The oxidative inactivation of tissue inhibitor of metalloproteinase-1 (TIMP-1) by hypochlorous acid (HOCI) is suppressed by anti-rheumatic drugs", Free Radic Res, 28, pp.115~123 (1998)
  35. Chapple IL, "The role of reactive oxygen and antioxidant species in periodontal tissue destruction", Periodontol 2000, 43, pp.160~232 (2007)
  36. Arredondo M, "Iron and copper metabolism", Mol Aspects Med, 26, pp.313~327 (2005)
  37. Peyssonnaux C, "Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis", J Immunol, 178, pp.7516~7519 (2007)
  38. Ichimura H, "Pressure-induced leukocyte margination in lung postcapillary venules", Am J Physiol Lung Cell Mol Physiol, 289, pp.L407~L412 (2005)
  39. Dallman PR, "Hematology of infancy and childhood. 5th ed", pp.430~476 (1998), W.B. Saunders

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