Adenosine 정주가 복강경 담낭절제술에서 시간 경과에 따라 술 중 혈압 변화와 술 후 통증에 미치는 영향
The Effect of Intravenous Adenosine Infusion on Temporal Intraoperative Blood Pressure Changes and Postoperative Pain Scores in Laparoscopic Cholecystectomy Patients
2
조회
0
다운로드
0
인용
0
참고문헌
초록
Abstract
Background: Adenosine has been shown to exert an antinociceptive effect under experimental conditions in animals and humans. This study was performed to evaluate the effects of adenosine on postoperative pain and intraoperative blood pressure changes. Methods: We studied 30 patients, aged <65 years, who underwent laparoscopic cholecystectomy under N2O-O2-isoflurane general anesthesia. Patients were randomized into two groups: an adenosine group (adenosine was infused continuously at 100-150 μg/kg/min, n = 15) and a control group (normal saline infused at 4 ml/min, n = 15). Mean arterial blood pressure during the intraoperative period, and pain score at 30 minutes, 6 hours, 24 hours, and 48 hours after operation were checked. On patient request, meperidine was administrated intravenously. Results: Pain scores and the cumulative doses of meperidine were much lower in the adenosine group than in the control group. The elevation of mean arterial pressure during pnemoperiton-eum was significantly attenuated in the adenosine group. Conclusions: This data suggests that intravenous adenosine infusion is effective at post-operative pain control following a laparoscopic cholecystectomy and that it is also effective at attenuating blood pressure elevation during pneumoperitoneum.
참고문헌 (19)
- "Adenosine:the prototypic neuromodulator", 14, pp.249~64 (1989)
- "Adenosine mediates sustained adrenergic desensitization in the rat heart via activation of protein kinase C", 83, pp.761~771 (1998)
- "Adenosine, an endogenous anti-inflammatory agent", ade(sine), pp.5~13 (1994)
- "Adenosine receptor activation and nociception", 347, pp.1~11 (1998)
- "Turnover of adenosine in plasma of human and dog blood", 256, pp.~806 (1989)
- "Peroperative adenosine infusion reduces the requirements for isoflurane and postoperative analgesics", 80, pp.1145~1149 (1995)
- "-baclofen have a neuromodulatory role in the rat spinal dorsal horn", ade(sine and), pp.1334~
- "Characterization of the antinociceptive effects of some adenosine analogues in the rat", 334, pp.290~3 (1986)
- "Adenosine infusion during isoflurane-nitrous oxide anaesthesia:indications of peroperative analgesic effect", 36, pp.595~9 (1992)
- "Comparision of adenosine and remifentanil infusions as adjuvants to desflurane anesthesia", 90, pp.956~963 (1999)
- "Hemodynamic changes during laparoscopic cholecystectomy", 76, pp.1067~71 (1993)
- "Cardiopulmonary function and laparoscopic cholecystectomy", 42, pp.51~63 (1995)
- "The relationship among carbon dioxide pneumoperitoneum,vasopressin release,and hemodynamic changes", 89, pp.278~283 (1999)
- "Preliminary efficacy assessment of intrathecal injection of an American formulation of adenosine in humans", 96, pp.29~34 (2002)
- "Adenosine inhibits neutrophil degranulation in activated human whole blood. Involvement of adenosine A2 and A3 receptors", 158, pp.5400~5408 (1997)
- "Acting via A2 receptors, adenosine inhibits the production of tumor necrosis factor- of endotoxin-stimulated human polymorphonuclear leukocytes", 126, pp.275~282 (1995)
- "Inhibition of TNF-α expression by adenosine. Role of A3 adenosine receptors", 156, pp.3435~3442 (1996)
- "Differential regulatory effect of adenosine on cytokine release by activated human monocytes", 153, pp.4159~68 (1994)
- "Characterization of the analgesic actions of adenosine:comparision of adenosine and remifentanil infusions in patients undergoing major surgical procedures", 101, pp.129~138 (2003)