척수 수준에서 Morphine의 진통 작용에 대한 Serotonin 3형 수용체 역할에 대한 평가
Assessment for the Role of Serotonin Receptor Subtype 3 for the Analgesic Action of Morphine at the Spinal Level
2
조회
0
다운로드
0
인용
0
참고문헌
초록
Abstract
Background: Serotonin 3 receptor is involved in the modulation of nociceptive transmission in the spinal cord. The serotonin 3 receptor antagonist has been used for the management of opioid-induced nausea and vomiting. The aim of this study was to examine whether the analgesic effect of morphine is antagonized by serotonin 3 receptor antagonists at the spinal level. Methods: Rats were implanted with lumbar intrathecal catheters. For nociception, a formalin solution (5%, 50μl) was injected into the hind paw of male Sprague-Dawley rats. To determine whether the effect of intrathecal morphine was mediated via serotonin 3 receptors, serotonin 3 receptor antagonists were intrathecally administered 10 min prior to the morphine delivery. Following the formalin injection, formalin-induced nociceptive behavior (flinching response) was observed for 60 min. Results: Intrathecal morphine produced a dose-dependent suppression of the flinches in both phases during the formalin test. The analgesic action of morphine was not reversed by serotonin 3 receptor antagonists (LY-278,584, ondansetron), which had little per se effect on the formalin-induced nociception. Conclusions: Spinal serotonin 3 receptors may not be involved in the analgesia of morphine on a nociceptive state evoked by a formalin stimulus.
참고문헌 (22)
- "Effect of intrathecal tramadol administration on postoperative pain after transurethral resection of prostate", 91, pp.536~40 (2003)
- "Side effects during continuous epidural infusion of morphine and fentanyl", 39, pp.576~82 (1992)
- "Mechanism of the anti-emetic activity of 5-HT3 receptor antagonists", 49, pp.263~8 (1992)
- "Transmitters involved in antinociception in the spinal cord", 48, pp.129~41 (1999)
- "Serotonin receptor subtypes involved in the spinal antinociceptive effect of 5-HT in rats", 86, pp.11~8 (2000)
- "Effects of 5-HT2 and 5-HT3 receptors on the modulation of nociceptive transmission in rat spinal cord according to the formalin test", 424, pp.45~52 (2001)
- "Roles of serotonin receptor subtypes for the antinociception of 5-HT in the spinal cord of rats", 502, pp.205~11 (2004)
- "Opioid-monoamine interactions in spinal antinociception:evidence for serotonin but not norepinephrine reciprocity", 34, pp.85~92 (1988)
- "Chronic catheterization of the spinal subarachnoid space", 17, pp.1031~6 (1976)
- "Pharmacology of spinal afferent processing Edited by Yaksh TL", pp.557~76 (1997), Lippincott-Raven Publishers
- "Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection:A microdialysis study in anesthetized rats", 15, pp.2768~76 (1995)
- "Release of substance P from the cat spinal cord", 391, pp.141~67 (1987)
- "inhibit substance P release from primary sensory neurons a model for presynaptic spinal opioid actions", pp.672~7
- "Prophylactic antiemetics for laparoscopic cholecystectomy", 14, pp.212~8 (2004)
- "Practical selection of antiemetics", 69, pp.1169~74 (2004)
- "Comparison of laser acupuncture and metoclopramide in PONV prevention in children", 15, pp.37~40 (2005)
- "Effect of stimulation of the P6 acupoint on opioid-induced nausea", 42, pp.450~4 (2002)
- "receptor antagonists for postoperative nausea and vomiting", 19, pp.225~38 (2005)
- "A review of central 5-HT receptors and their function", 38, pp.1083~152 (1999)
- "5-HT3 receptors in the rat central nervous system are mainly located on nerve fibres and terminals", 612, pp.289~98 (1993)
- "Distribution of serotonin 2A 2C and 3 receptor mRNA in spinal cord and medulla oblongata", 89, pp.11~9 (2001)
- "Distribution of serotonin 2A 2C and 3 receptor mRNA in spinal cord and medulla oblongata", 89, pp.11~9 (2001)