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척수신경결찰 흰쥐에서 척수강내로 투여한 Lamotrigine의 기계적 항이질통 효과

The Mechanical Antiallodynic Effect of Intrathecal Lamotrigine in Rats with Spinal Nerve Ligation

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Abstract

Background: A nerve ligation injury may produce a tactile allodynia. The effects of intrathecally delivered lamotrigine on allodynia induced due to fifth and sixth lumbar spinal nerves ligation in rats, using lumbar intrathecal catheters were examined. Methods: Sprague-Dawley rats (body weight 160-180 g) were prepared by tightly ligating the fifth and sixth left lumbar spinal nerves, with the implantation of a chronic intrathecal catheter for drug administration. Mechanical allodynia and allodynic threshold were measured using von Frey filaments and the updown method, respectively. After the baseline hind paw withdrawal thresholds had been obtained, lamotrigine (10, 30, 100 and 300μg) was administered intrathecally. Thereafter, the dose-response curves and 50% effective dose (ED50) were obtained. Motor dysfunction was assessed by observing the righting/stepping reflex responses and abnormal weight bearing. Results: Intrathecal administration of lamotrigine produced a dose-dependent antiallodynic action (ED50 = 61.7μg). Mild motor weakness was observed with 300μg lamotrigine, but no severe motor impairment was found. Conclusions: It is suggested that intrathecal lamotrigine could produce moderate antagonism of mechanical allodynia at the spinal level in a rat neuropathic pain model with minimal motor weakness.

참고문헌 (44)

  1. "Chung JM:Signs of neuropathic pain depend on signals from injured nerve fibers in a rat model", 610, pp.62~8 (1993)
  2. "An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat", 50, pp.355~63 (1992)
  3. "Anticonvulsants (antineuropathics) for neuropathic pain syndromes", 16, pp.67~72 (2000)
  4. "Anticonvulsants for neuropathic pain syndromes:mechanisms of action and place in therapy", 60, pp.1029~52 (2000)
  5. "Anticonvulsant drugs for management of pain:a systematic review", 311, pp.1047~52 (1995)
  6. "Efficacy of pharmacological treatments of neuropathic pain:an update and effect related to mechanism of drug action", 83, pp.389~400 (1999)
  7. "Gabapentin for the treatment of postherpetic neuralgia:a randomized controlled trial", 280, pp.1837~42 (1998)
  8. "Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus:a randomized controlled trial", 280, pp.1831~6 (1998)
  9. "Oxcarbazepine:a new drug in the management of intractable trigeminal neuralgia", 52, pp.472~6 (1989)
  10. "Gabapentin in postherpetic neuralgia", 94, pp.215~24 (2001)
  11. "A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man", 33, pp.87~107 (1988)
  12. "A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury", 43, pp.205~18 (1990)
  13. "Pharmacological studies on a rat model of trigeminal neuropathic pain morphine or tricyclic antidepressants attenuates the allodynia- like behaviour", 79, pp.281~90 (1999)
  14. "Effect of lamotrigine in the acute and chronic hyperalgesia induced by PGE2 and in the chronic hyperalgesia in rats with streptozotocin-induced diabetes", 63, pp.33~7 (1995)
  15. "The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain", 324, pp.153~60 (1997)
  16. "Gabapentin and pregabalin,but not morphine and amitriptyline,block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat", 80, pp.391~8 (1999)
  17. "Effect of gabapentin and lamotrigine on mechanical allodynia-like behaviour in a rat model of trigeminal neuropathic pain", 93, pp.147~53 (2001)
  18. "An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels", 13, pp.107~12 (1992)
  19. "Lamotrigine protects against kainate but not ibotenate lesions in rat striatum", 112, pp.348~51 (1990)
  20. "Lamotrigine in the management of neuropathic pain:a review of the literature", 16, pp.321~6 (2000)
  21. "Chronic catheterization of the spinal subarachnoid space", 17, pp.1031~6 (1976)
  22. "Quantitative assessment of tactile allodynia in the rat paw", 53, pp.55~63 (1994)
  23. "Statistical analysis of drug-drug and site-site interactions with isobolograms", 45, pp.947~61 (1989)
  24. "The pathophysiology of chronic pain-increased sensitivity to lowthreshold Aβ-fibre inputs", 4, pp.525~34 (1994)
  25. "The Changes of metabotrophic glutamate receptor type 5 in allodynia induced by nerve ligation", 12, pp.8~15 (1999)
  26. "Spontaneous discharge originates in the dorsal root ganglion at the onset of a painful peripheral neruopathy in the rat", 138, pp.225~8 (1992)
  27. "Transsynaptic degeneration in the superficial dorsal horn after sciatic nerve injury effects of a chronic constriction injury", pp.205~13
  28. "Sprouting of Aβ fibers into lamina II of the rat dorsal horn in peripheral neuropathy", 208, pp.147~50 (1996)
  29. "Sprouting of sympathetic nerve fibers into the dorsal root ganglion following peripheral nerve injury depends on the injury site", 212, pp.191~4 (1996)
  30. "Pharmacologic treatment of pain in polyneuropathy", 55, pp.915~20 (2000)
  31. "Lamotrigine protects against kainate but not ibotenate lesions in rat striatum", 112, pp.348~51 (1990)
  32. "Pharmacological studies of lamotrigine Neurochemical studies on the mechanism of action", pp.490~7
  33. "Lamotrigine inhibits extracellular glutamate during transient global ischemia in rabbits", 86, pp.459~63 (1997)
  34. "Non-opioid actions of lamotrigine within the rat dorsal horn after inflammation and neuropathic nerve damage", 39, pp.385~90 (2001)
  35. "200 mg daily of lamotrigine has no analgesic effect in neuropathic pain: a randomised, double-blind, placebo controlled trial", 83, pp.105~7 (1999)
  36. "Reply to Jaques Devulder", 86, pp.211~2 (2000)
  37. "Spared nerve injury:an animal model of persistent peripheral neuropathic pain", 87, pp.149~58 (2000)
  38. "Photochemically induced ischaemic lesion of the rat sciatic nerve A novel method providing high incidence of mononeuropathy", pp.2619~23
  39. "A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury", 43, pp.205~18 (1990)
  40. "Vincristine-induced allodynia in the rat", 93, pp.69~76 (2001)
  41. "A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man", 33, pp.87~107 (1988)
  42. "The thermal and mechanical anti-hyperalgesic effects of pre- versus post- intrathecal treatment with lamotrigine in a rat model of inflammatory pain", 70, pp.3039~47 (2002)
  43. "Effects of intrathecally administered lamotrigine,a glutamate release inhibitor,on short- and long-term models of hyperalgesia in rats", 88, pp.487~94 (1998)
  44. "Effects of intrathecally administered lamotrigine,a glutamate release inhibitor,on short- and long-term models of hyperalgesia in rats", 88, pp.487~94 (1998)

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