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임플란트주위염시 Porphyromonas gingivalis 섬모유전형의 출현율

Prevalence of fimA Genotypes of Porphyromonas gingivalis Strains in peri-implantitis patients

정종혁|권영혁|박준봉|신승일|허익
대한치주과학회 (The Korean Academy Of Periodontology)|2005.03|Journal of Periodontal & Implant Science|제35권 제1호|pp. 31-42

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참고문헌

주제분류치의학

초록

Abstract

Fimbriae (fimA) of Porphyromonas gingivalis are filamentous components on the cell surface and are thought to play an important role in the colonization and invasion of periodontal tissue. P. gnigivalis fimA gene encoding fimbrillin, a subunit of fimbriae, has been classified into 5 genotypes (typesⅠ to Ⅴ) based on the nucleotide sequences. In the present study, we examined the prevalence of these fimA genotypes in patients with dental implant and the relationship between prevalence of these genotypes and peri-implantitis. Dental plaque specimens obtained from 80 peri-implant sulci of 50 patients with dental implants were analyzed by 16S rRNA fimA gene-directed PCR assay. P. gingivalis were detected in 74.4% of the samples of the control group (healthy peri- implant sulci; probing depth<5㎜) and in 92.0% of the samples of the test group (peri-implant sulci with peri-iimplantitis; probing depth≧5㎜). Among the P. gingivalis-positive samples of the control group, the most prevalent fimA type was typeⅠ(29.3%), followed by typeⅡ(26.8%). In contrast, a majority among the P. gingivalis-positive samples of the test group was typeⅡ(56.5%), followed by typeⅠ(43.5%). TypeⅡ fimA genotype organisms were detected more frequently in the test group and a significant difference in the occurrence of typeⅡ was observed between test and the control groups. A correlation between specific fimA types and peri-implant health status was found in typeⅡ(OR 3.545) and only a weak relationship was revealed in typeⅣ(OR 3.807). These findings indicate that P. gingivalis strains that possess typeⅡ fimA are predominant in peri-implant sulci with peri-implantitis and are closely associated with peri-implant health status. P. gingivalis with typeⅡ fimA may be involved in peri-implantitis

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