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Prognostication of the Last Days of Life

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초록

Accurate prediction of impending death (i.e., last few days of life) is essential for terminally-ill cancer patients and their families. International guidelines state that clinicians should identify patients with impending death, communicate the prognosis with patients and families, help them with their end-of-life decision-making, and provide sufficient symptom palliation. Over the past decade, several national and international studies have been conducted that systematically investigated signs and symptoms of impending death as well as how to communicate such a prognosis effectively with patients and families. In this article, we summarize the current evidence on prognostication and communication regarding the last days of life of patients with cancer, and future directions of clinical research.

Abstract

Accurate prediction of impending death (i.e., last few days of life) is essential for terminally-ill cancer patients and their families. International guidelines state that clinicians should identify patients with impending death, communicate the prognosis with patients and families, help them with their end-of-life decision-making, and provide sufficient symptom palliation. Over the past decade, several national and international studies have been conducted that systematically investigated signs and symptoms of impending death as well as how to communicate such a prognosis effectively with patients and families. In this article, we summarize the current evidence on prognostication and communication regarding the last days of life of patients with cancer, and future directions of clinical research.

참고문헌 (76)

  1. Ruegger J, "Care of adults in the last days of life : summary of NICE guidance", BMJ, 351, pp.h6631~ (2015)
  2. "Palliative care (version 2.2019)" (2019)[URL]
  3. Miyashita M, "Good death in cancer care : a nationwide quantitative study", Ann Oncol, 18, pp.1090~1097 (2007)
  4. Masterson MP, "Beyond the bucket list : unfinished and business among advanced cancer patients", Psychooncology, 27, pp.2573~2580 (2018)
  5. Domeisen Benedetti F, "International palliative care experts’ view on phenomena indicating the last hours and days of life", Support Care Cancer, 21, pp.1509~1517 (2013)
  6. Hui D, "Clinical signs of impending death in cancer patients", Oncologist, 19, pp.681~687 (2014)
  7. Hui D, "Bedside clinical signs associated with impending death in patients with advanced cancer : preliminary findings of a prospective, longitudinal cohort study", Cancer, 121, pp.960~967 (2015)
  8. Hui D, "Symptom expression in the last seven days of life among cancer patients admitted to acute palliative care units", J Pain Symptom Manage, 50, pp.488~494 (2015)
  9. Bruera S, "Frequency and factors associated with unexpected death in an acute palliative care unit : expect the unexpected", J Pain Symptom Manage, 49, pp.822~827 (2015)
  10. Bruera S, "Variations in vital signs in the last days of life in patients with advanced cancer", J Pain Symptom Manage, 48, pp.510~517 (2014)
  11. Mori M, "Diagnostic models for impending death in terminally ill cancer patients : a multicenter cohort study", Cancer Med, 10, pp.7988~7995 (2021)
  12. Ikari T, ""3-Day Surprise Question"to predict prognosis of advanced cancer patients with impending death : multicenter prospective observational study", Cancer Med, 10, pp.1018~1026 (2021)
  13. Ito S, "Incidence and associated factors of sudden unexpected death in advanced cancer patients : a multicenter prospective cohort study", Cancer Med, 10, pp.4939~4947 (2021)
  14. Yamaguchi T, "Communication and behavior of palliative care physicians of patients with cancer near end of life in three East Asian countries", J Pain Symptom Manage, 61, pp.315~322 (2021)
  15. Mori M, "Communication about the impending death of patients with cancer to the family : a nationwide survey", BMJ Support Palliat Care, 8, pp.221~228 (2018)
  16. Morita T, "A prospective study on the dying process in terminally ill cancer patients", Am J Hosp Palliat Care, 15, pp.217~222 (1998)
  17. Hui D, "Prognostication of survival in patients with advan-ced cancer : predicting the unpredictable?", Cancer Control, 22, pp.489~497 (2015)
  18. Llobera J, "Terminal cancer. duration and prediction of survival time", Eur J Cancer, 36, pp.2036~2043 (2000)
  19. Hui D, "The accuracy of probabilistic versus temporal clinician prediction of survival for patients with advanced cancer : a preliminary report", Oncologist, 16, pp.1642~1648 (2011)
  20. Amano K, "The accuracy of physicians’ clinical predictions of survival in patients with advanced cancer", J Pain Symptom Manage, 50, pp.139~146 (2015)
  21. Christakis NA, "Extent and determinants of error in doctors’ prognoses in terminally ill patients : prospective cohort study", BMJ, 320, pp.469~472 (2000)
  22. Perez-Cruz PE, "Longitudinal temporal and probabilistic prediction of survival in a cohort of patients with advanced cancer", J Pain Symptom Manage, 48, pp.875~882 (2014)
  23. Selby D, "Clinician accuracy when estimating survival duration : the role of the patient’s performance status and time-based prognostic categories", J Pain Symptom Manage, 42, pp.578~588 (2011)
  24. Hui D, "Predicting survival in patients with advanced cancer in the last weeks of life : How accurate are prognostic models compared to clinicians’ estimates?", Palliat Med, 34, pp.126~133 (2020)
  25. Downar J, "The"surprise question"for predicting death in seriously ill patients : a systematic review and meta-analysis", CMAJ, 189, pp.E484~E493 (2017)
  26. White N, "How accurate is the ‘Surprise Question’ at identifying patients at the end of life? A systematic review and meta-analysis", BMC Med, 15, pp.139~ (2017)
  27. Hamano J, "Surprise questions for survival prediction in patients with advanced cancer : a multicenter prospective cohort study", Oncologist, 20, pp.839~844 (2015)
  28. Ikari T, "Is the 1-day surprise question a useful screening tool for predicting prognosis in patients with advanced cancer?-a multicenter prospective observational study", Ann Palliat Med, 10, pp.11278~11287 (2021)
  29. Kim SH, "“The surprise questions” using variable time frames in hospitalized patients with advanced cancer", Palliat Support Care, 20, pp.221~225 (2022)
  30. Chen YT, "Objective palliative prognostic score among patients with advanced cancer", J Pain Symptom Manage, 49, pp.690~696 (2015)
  31. Gwilliam B, "Development of prognosis in palliative care study(PiPS)predictor models to improve prognostication in advanced cancer : prospective cohort study", BMJ Support Palliat Care, 5, pp.390~398 (2015)
  32. Hamano J, "A combination of routine laboratory findings and vital signs can predict survival of advanced cancer patients without physician evaluation : a fractional polynomial model", Eur J Cancer, 105, pp.50~60 (2018)
  33. Maltoni M, "Successful validation of the palliative prognostic score in terminally ill cancer patients. Italian Multicenter Study Group on Palliative Care", J Pain Symptom Manage, 17, pp.240~247 (1999)
  34. Suh SY, "Construction of a new, objective prognostic score for terminally ill cancer patients : a multicenter study", Support Care Cancer, 18, pp.151~157 (2010)
  35. Nagasako Y, "Acute palliative care unit-initiated interventions for advanced cancer patients at the end of life : prediction of impending death based on Glasgow Prognostic Score", Support Care Cancer, 29, pp.1557~1564 (2021)
  36. Gupta D, "Bioelectrical impedance phase angle in clinical practice : implications for prognosis in stage IIIB and IV non-small cell lung cancer", BMC Cancer, 9, pp.37~ (2009)
  37. Norman K, "Cutoffpercentiles of bioelectrical phase angle predict functionality, quality of life, and mortality in patients with cancer", Am J Clin Nutr, 92, pp.612~619 (2010)
  38. Barbosa-Silva MC, "Bioelectrical impedance analysis : population reference values for phase angle by age and sex", Am J Clin Nutr, 82, pp.49~52 (2005)
  39. Hui D, "Phase angle and the diagnosis of impending death in patients with advanced cancer : preliminary findings", Oncologist, 24, pp.e365~e373 (2019)
  40. Hui D, "Acute symptomatic complications among patients with advanced cancer admitted to acute palliative care units : a prospective observational study", Palliat Med, 29, pp.826~833 (2015)
  41. Seow H, "Trajectory of performance status and symptom scores for patients with cancer during the last six months of life", J Clin Oncol, 29, pp.1151~1158 (2011)
  42. Suh SY, "Assessment of changes in symptoms is feasible and prognostic in the last weeks of life : an international multicenter cohort study", J Palliat Med, 25, pp.388~395 (2022)
  43. Morita T, "The Palliative Prognostic Index : a scoring system for survival prediction of terminally ill cancer patients", Support Care Cancer, 7, pp.128~133 (1999)
  44. Hui D, "A diagnostic model for impending death in cancer patients : preliminary report", Cancer, 121, pp.3914~3921 (2015)
  45. Hui D, "Unexpected death in palliative care : what to expect when you are not expecting", Curr Opin Support Palliat Care, 9, pp.369~374 (2015)
  46. Wilcock A, "Hospices and CPR guidelines : sudden and unexpected death in a palliative care unit", BMJ, 338, pp.b2343~ (2009)
  47. Ekstrom M, "Prevalence of sudden death in palliative care : data from the Australian palliative care outcomes collaboration", J Pain Symptom Manage, 52, pp.221~227 (2016)
  48. Scott K, "Incidence of sudden, unexpected death in a specialist palliative care inpatient setting", Palliat Med, 24, pp.449~450 (2010)
  49. Virdun C, "Dying in the hospital setting : a systematic review of quantitative studies identifying the elements of end-of-life care that patients and their families rank as being most important", Palliat Med, 29, pp.774~796 (2015)
  50. Virdun C, "Dying in the hospital setting : a meta-synthesis identifying the elements of end-of-life care that patients and their families describe as being important", Palliat Med, 31, pp.587~601 (2017)
  51. Imai K, "Efficacy of proportional sedation and deep sedation defined by sedation protocols : a multicenter, prospective, observational comparative study", J Pain Symptom Manage, 62, pp.1165~1174 (2021)
  52. Mori M, "How successful is parenteral oxycodone for relieving terminal cancer dyspnea compared with morphine? A multicenter prospective observational study", J Pain Symptom Manage, 62, pp.336~345 (2021)
  53. Mori M, "How successful are we in relieving terminal dyspnea in cancer patients? A real-world multicenter prospective observational study", Support Care Cancer, 28, pp.3051~3060 (2020)
  54. Hui D, "Neuroleptic strategies for terminal agitation in patients with cancer and delirium at an acute palliative care unit : a single-centre, double-blind, parallel-group, randomised trial", Lancet Oncol, 21, pp.989~998 (2020)
  55. Hui D, "Effect of lorazepam with haloperidol vs haloperidol alone on agitated delirium in patients with advanced cancer receiving palliative care : a randomized clinical trial", JAMA, 318, pp.1047~1056 (2017)
  56. Tse CY, "Breaking bad news : a Chinese perspective", Palliat Med, 17, pp.339~343 (2003)
  57. Hancock K, "Truth-telling in discussing prognosis in advanced life-limiting illnesses : a systematic review", Palliat Med, 21, pp.507~517 (2007)
  58. Jaturapatporn D, "Attitudes towards truth-telling about cancer : a survey from Thailand", Palliat Med, 22, pp.97~98 (2008)
  59. Seo M, "Telling the diagnosis to cancer patients in Japan : attitude and perception of patients, physicians and nurses", Palliat Med, 14, pp.105~110 (2000)
  60. Syed AA, "Barriers and perceptions regarding code status discussion with families of critically ill patients in a tertiary care hospital of a developing country : a cross-sectional study", Palliat Med, 31, pp.147~157 (2017)
  61. Martina D, "Asian patients’ perspectives on advance care planning : a mixed-method systematic review and conceptual framework", Palliat Med, 35, pp.1776~1792 (2021)
  62. Mori M, "End-of-life decision-making in Asia: a need for in-depth cultural consideration", Palliat Med, pp.269216319896932~ (2020)
  63. Haugen DF, "Good quality care for cancer patients dying in hospitals, but information needs unmet : bereaved relatives’ survey within seven countries", Oncologist, 26, pp.e1273~e1284 (2021)
  64. Shimizu Y, "Care strategy for death rattle in terminally ill cancer patients and their family members : recommendations from a cross-sectional nationwide survey of bereaved family members’ perceptions", J Pain Symptom Manage, 48, pp.2~12 (2014)
  65. Mori M, "Which physicians’ behaviors on death pronouncement affect family-perceived physician compassion? A randomized, scripted, video-vignette study", J Pain Symptom Manage, 55, pp.189~197 (2018)
  66. Yamashita R, "Unfinished business in families of terminally ill with cancer patients", J Pain Symptom Manage, 54, pp.861~869 (2017)
  67. Mori M, ""What I did for my loved one is more important than whether we talked about death" : a nationwide survey of bereaved family members", J Palliat Med, 21, pp.335~341 (2018)
  68. Shirado A, "Both maintaining hope and preparing for death : effects of physicians’ and nurses’ behaviors from bereaved family members’ perspectives", J Pain Symptom Manage, 45, pp.848~858 (2013)
  69. Hui D, "The importance of prognostication : impact of prognostic predictions, disclosures, awareness, and acceptance on patient outcomes", Curr Treat Options Oncol, 22, pp.12~ (2021)
  70. Butow PN, "Prognostic awareness in adult oncology and palliative care", J Clin Oncol, 38, pp.877~884 (2020)
  71. Mori M, "The bereaved families’ preferences for individualized goals of care for terminal dyspnea : what is an acceptable balance between dyspnea intensity and communication capacity?", Palliat Med Rep, 1, pp.42~49 (2020)
  72. Hui D, "Personalized sedation goal for agitated delirium in patients with cancer : balancing comfort and communication", Cancer, 127, pp.4694~4701 (2021)
  73. Mori M, "Unanswered questions and future direction in the management of terminal breathlessness in patients with cancer", ESMO Open, 1, pp.e000603~ (2020)
  74. Uchida M, "Are common delirium assessment tools appropriate for evaluating delirium at the end of life in cancer patients?", Psychooncology, 29, pp.1842~1849 (2020)
  75. Mori M, "Visualizing how to use parenteral opioids for terminal cancer dyspnea : a pilot, multicenter, prospective, observational study", J Pain Symptom Manage, 62, pp.936~948 (2021)
  76. Nakazato K, "Verbal communication of families with cancer patients at end of life : a questionnaire survey with bereaved family members", Psychooncology, 27, pp.155~162 (2018)

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