Effects of Palonosetron, a 5-HT3 Receptor Antagonist, on Mechanical Allodynia in a Rat Model of Postoperative Pain
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Background:5-hydroxytryptamine 3 (5-HT3) receptors have been known to be associated with the modulation of nociceptive transmission. However, it is uncertain whether 5-HT3 plays a role in the antinociceptive or pronociceptive pathway for incisional pain. In this study, we evaluated the effects of palonosetron, a 5-HT3 receptor antagonist, on incisional pain in rats when administered intrathecally or intraplantarly. Methods:An intrathecal catheter was implanted through the cisterna magna and placed in the intrathecal space of rats. An incision in the plantaris muscle of the right hind paw was done under anesthesia with sevoflurane. Withdrawal thresholds were evaluated with the von Frey filament after 2 hours. Palonosetron (0.5 and 0.1 mg intrathecally; 0.5 mg intraplantarly) was administered and the thresholds were observed for 4 hours. Results:Mechanical hypersensitivity developed after the incision. Intrathecal palonosetron (0.5 mg and 0.1 mg) did not alter the paw withdrawal threshold. Intraplantar palonosetron (0.5 mg) also did not change the paw withdrawal threshold. Conclusions:Intrathecal and intraplantar palonosetron (0.5 mg) had no effect on modulating the mechanical hypersensitivity in the incisional pain model of rats.
Abstract
Background:5-hydroxytryptamine 3 (5-HT3) receptors have been known to be associated with the modulation of nociceptive transmission. However, it is uncertain whether 5-HT3 plays a role in the antinociceptive or pronociceptive pathway for incisional pain. In this study, we evaluated the effects of palonosetron, a 5-HT3 receptor antagonist, on incisional pain in rats when administered intrathecally or intraplantarly. Methods:An intrathecal catheter was implanted through the cisterna magna and placed in the intrathecal space of rats. An incision in the plantaris muscle of the right hind paw was done under anesthesia with sevoflurane. Withdrawal thresholds were evaluated with the von Frey filament after 2 hours. Palonosetron (0.5 and 0.1 mg intrathecally; 0.5 mg intraplantarly) was administered and the thresholds were observed for 4 hours. Results:Mechanical hypersensitivity developed after the incision. Intrathecal palonosetron (0.5 mg and 0.1 mg) did not alter the paw withdrawal threshold. Intraplantar palonosetron (0.5 mg) also did not change the paw withdrawal threshold. Conclusions:Intrathecal and intraplantar palonosetron (0.5 mg) had no effect on modulating the mechanical hypersensitivity in the incisional pain model of rats.
참고문헌 (23)
- Faerber L, "The neuronal 5-HT3 receptor network after 20 years of research--evolving concepts in management of pain and inflammation", Eur J Pharmacol, 560, pp.1~8 (2007)
- 윤명하, "척수에서 침해자극 전달 조절에 대한 5-Hydroxytryptamine수용체 아형별 역할에 대한 평가", Korean Journal of Anesthesiology, 47(6), pp.856~861 (2004), 대한마취통증의학회
- Ali Z, "The role of 5HT3 in nociceptive processing in the rat spinal cord: results from behavioural and electrophysiological studies", Neurosci Lett, 208, pp.203~207 (1996)
- McCleane GJ, "Does a single intravenous injection of the 5HT3 receptor antagonist ondansetron have an analgesic effect in neuropathic pain? A double-blinded, placebo-controlled cross-over study", Anesth Analg, 97, pp.1474~1478 (2003)
- Yaksh TL, "Chronic catheterization of the spinal subarachnoid space", Physiol Behav, 17, pp.1031~1036 (1976)
- Brennan TJ, "Characterization of a rat model of incisional pain", Pain, 64, pp.493~501 (1996)
- 신동진, "백서를 이용한 수술 후 통증 유발 모형에서 척수강 내로 투여한 Ginsenosides의 효과", The Korean Journal of Pain, 20(2), pp.100~105 (2007), 대한통증학회
- Wong EH, "The interaction of RS 25259-197, a potent and selective antagonist, with 5-HT3 receptors, in vitro", Br J Pharmacol, 114, pp.851~859 (1995)
- Kovac AL, "A randomized, doubleblind study to evaluate the efficacy and safety of three different doses of palonosetron versus placebo in preventing postoperative nausea and vomiting over a 72-hour period", Anesth Analg, 107, pp.439~444 (2008)
- Alhaider AA, "Spinal 5-HT3 receptormediated antinociception: possible release of GABA", J Neurosci, 11, pp.1881~1888 (1991)
- Suzuki R, "Bad news from the brain: descending 5-HT pathways that control spinal pain processing", Trends Pharmacol Sci, 25, pp.613~617 (2004)
- Suzuki R, "Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways", Nat Neurosci, 5, pp.1319~1326 (2002)
- Rahman W, "Selective ablation of dorsal horn NK1 expressing cells reveals a modulation of spinal alpha2-adrenergic inhibition of dorsal horn neurones", Neuropharmacology, 54, pp.1208~1214 (2008)
- Oatway MA, "The 5-HT3 receptor facilitates at-level mechanical allodynia following spinal cord injury", Pain, 110, pp.259~268 (2004)
- Vandermeulen EP, "Alterations in ascending dorsal horn neurons by a surgical incision in the rat foot", Anesthesiology, 93, pp.1294~1302 (2000)
- Zahn PK, "Mechanisms for pain caused by incisions", Reg Anesth Pain Med, 27, pp.514~516 (2002)
- Pogatzki EM, "Role of the rostral medial medulla in the development of primary and secondary hyperalgesia after incision in the rat", Anesthesiology, 96, pp.1153~1160 (2002)
- Zeitz KP, "The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors", J Neurosci, 22, pp.1010~1019 (2002)
- Rahman W, "Depletion of endogenous spinal 5-HT attenuates the behavioural hypersensitivity to mechanical and cooling stimuli induced by spinal nerve ligation", Pain, 123, pp.264~274 (2006)
- Kress M, "An interaction of inflammatory mediators and protons in small diameter dorsal root ganglion neurons of the rat", Neurosci Lett, 224, pp.37~40 (1997)
- Sommer C, "Is serotonin hyperalgesic or analgesic?", Curr Pain Headache Rep, 10, pp.101~106 (2006)
- Eschalier A, "Influence of a specific 5-HT3 antagonist on carrageenan-induced hyperalgesia in rats", Pain, 36, pp.249~255 (1989)
- Park SK, "A randomized, double-blind trial of palonosetron compared with ondansetron in preventing postoperative nausea and vomiting after gynaecological laparoscopic surgery", J Int Med Res, 39, pp.399~407 (2011)
