Evaluation of Salivary Cortisol and Anxiety Levels in Myofascial Pain Dysfunction Syndrome
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Background: Myofascial pain dysfunction syndrome (MPDS), otherwise called myofascial pain is one of the most common temporomandibular disorders, which in turn is the most common cause of orofacial pain of non-dental origin. Its etiology is multifactorial and still poorly understood. Psychological factors have been shown to play a role in the etiology. The aim of the study was to evaluate the association between anxiety and salivary cortisol levels in patients with myofascial pain. Methods: Twenty patients suffering from myofascial pain were recruited as the study group. The same number of age and sex matched healthy individuals were taken as the control group. The salivary samples collected between 9−9:15 am from both groups were analyzed for cortisol levels with the competitive enzyme-linked immunosorbent assay method. Anxiety levels of 40 patients were measured using Hamilton’s anxiety scale. Results: The mean serum cortisol level of the MPDS group showed a highly significant difference (P ＜ 0.001) from the controls. The mean anxiety scores of the MPDS group showed a highly significant difference (P ＜ 0.001) from the controls. A positive correlation was found between anxiety and the salivary cortisol levels in MPDS patients. Conclusions: These findings suggest that anxiety plays a vital role in the etio-pathogenesis of MPDS; thus, besides pharmacological treatment, psychological support is also needed.
Abstract
Background: Myofascial pain dysfunction syndrome (MPDS), otherwise called myofascial pain is one of the most common temporomandibular disorders, which in turn is the most common cause of orofacial pain of non-dental origin. Its etiology is multifactorial and still poorly understood. Psychological factors have been shown to play a role in the etiology. The aim of the study was to evaluate the association between anxiety and salivary cortisol levels in patients with myofascial pain. Methods: Twenty patients suffering from myofascial pain were recruited as the study group. The same number of age and sex matched healthy individuals were taken as the control group. The salivary samples collected between 9−9:15 am from both groups were analyzed for cortisol levels with the competitive enzyme-linked immunosorbent assay method. Anxiety levels of 40 patients were measured using Hamilton’s anxiety scale. Results: The mean serum cortisol level of the MPDS group showed a highly significant difference (P ＜ 0.001) from the controls. The mean anxiety scores of the MPDS group showed a highly significant difference (P ＜ 0.001) from the controls. A positive correlation was found between anxiety and the salivary cortisol levels in MPDS patients. Conclusions: These findings suggest that anxiety plays a vital role in the etio-pathogenesis of MPDS; thus, besides pharmacological treatment, psychological support is also needed.
참고문헌 (25)
- Rollman GB, "The role of psychosocial factors in temporomandibular disorders", Curr Rev Pain, 4, pp.71~81 (2000)
- Machado LP, "The prevalence of clinical diagnostic groups in patients with temporomandibular disorders", Cranio, 27, pp.194~199 (2009)
- Dworkin SF, "Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique", J Craniomandib Disord, 6, pp.301~355 (1992)
- Chee Kean Chen, "Myofascial Pain Syndrome in Chronic Back Pain Patients", The Korean Journal of Pain, 24(2), pp.100~104 (2011), 대한통증학회
- Reissmann DR, "Psychosocial profiles of diagnostic subgroups of temporomandibular disorder patients", Eur J Oral Sci, 116, pp.237~244 (2008)
- Oral K, "Etiology of temporomandibular disorder pain", Agri, 21, pp.89~94 (2009)
- Jones DA, "The cortisol response to psychological stress in temporomandibular dysfunction", Pain, 72, pp.171~182 (1997)
- Yoshihara T, "Neuroendocrine responses to psychological stress in patients with myofascial pain", J Orofac Pain, 19, pp.202~208 (2005)
- Koray M, "The evaluation of anxiety and salivary cortisol levels in patients with oral lichen planus", Oral Dis, 9, pp.298~301 (2003)
- Safarzadeh E, "Determination of salivary cortisol in healthy children and adolescents", Acta Med Iran, 43, pp.32~36 (2005)
- Truelove E, "The research diagnostic criteria for temporomandibular disorders. III: validity of Axis I diagnoses", J Orofac Pain, 24, pp.35~47 (2010)
- Hamilton M, "The assessment of anxiety states by rating", Br J Med Psychol, 32, pp.50~55 (1959)
- Manfredini D, "Psychosocial profiles of painful TMD patients", J Oral Rehabil, 36, pp.193~198 (2009)
- Kight M, "Temporomandibular disorders : evidence for significant overlap with psychopathology", Health Psychol, 18, pp.177~182 (1999)
- Manfredini D, "Mood and anxiety psychopathology and temporomandibular disorder : a spectrum approach", J Oral Rehabil, 31, pp.933~940 (2004)
- Uhac I, "The influence of war stress on the prevalence of signs and symptoms of temporomandibular disorders", J Oral Rehabil, 30, pp.211~217 (2003)
- Mercuri LG, "The specificity of response to experimental stress in patients with myofascial pain dysfunction syndrome", J Dent Res, 58, pp.1866~1871 (1979)
- Charney DS, "Psychobiological mechanisms of resilience and vulnerability : implications for successful adaptation to extreme stress", Am J Psychiatry, 161, pp.195~216 (2004)
- Tortora GJ, "Introduction to the human body:the essentials of anatomy and physiology" (2000), Wiley
- Breedlove SM, "Biological psychology:an introduction to behavioral, cognitive, and clinical neuroscience" (2007), Sinauer Associates cop
- Korszun A, "Basal circadian cortisol secretion in women with temporomandibular disorders", J Dent Res, 81, pp.279~283 (2002)
- Nilsson AM, "Perceived symptoms of psychological distress and salivary cortisol levels in young women with muscular or disk-related temporomandibular disorders", Acta Odontol Scand, 68, pp.284~288 (2010)
- Yap AU, "Clinical TMD, pain-related disability and psychological status of TMD patients", J Oral Rehabil, 29, pp.374~380 (2002)
- Yap AU, "Prevalence of temporomandibular disorder subtypes, psychologic distress, and psychosocial dysfunction in Asian patients", J Orofac Pain, 17, pp.21~28 (2003)
- Nifosì F, "Psychopathology and clinical features in an Italian sample of patients with myofascial and temporomandibular joint pain: preliminary data", Int J Psychiatry Med, 37, pp.283~300 (2007)