Platelet-rich fibrin along with a modified minimally invasive surgical technique for the treatment of intrabony defects: a randomized clinical trial
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Purpose: The modified minimally invasive surgical technique (M-MIST) has been successfully employed to achieve periodontal regeneration. Platelet-rich fibrin (PRF) is known to enhance wound healing through the release of growth factors. This study aimed to observe the outcomes of periodontal surgery when M-MIST was used with or without PRF for the treatment of isolated intrabony defects. Methods: This randomized clinical trial was conducted on 36 systemically healthy patients, who had chronic periodontitis associated with a single-site buccal probing pocket depth (PPD) and clinical attachment level of ≥5 mm. Patients were randomly divided into 2 groups: the test group treated with M-MIST and PRF, and the control group treated with M-MIST alone. The primary periodontal parameters analyzed were PPD, relative attachment level (RAL), and relative gingival margin level. The radiographic parameters analyzed were change in alveolar crest position (C-ACP), linear bone growth (LBG), and percentage bone fill (%BF). Patients were followed up to 6 months post-surgery. Results: Intragroup comparisons at 3 and 6 months showed consistently significant improvements in PPD and RAL in both the groups. In intergroup comparisons, the improvement in PPD reduction, gain in RAL, and the level of the gingival margin was similar in both groups at 3 and 6 months of follow-up. Furthermore, an intergroup comparison of radiographic parameters also demonstrated similar improvements in C-ACP, LBG, and %BF at 6 months of follow-up. Conclusions: M-MIST with or without PRF yielded comparable periodontal tissue healing in terms of improvements in periodontal and radiographic parameters. Further investigation is required to confirm the beneficial effects of PRF with M-MIST.
Abstract
Purpose: The modified minimally invasive surgical technique (M-MIST) has been successfully employed to achieve periodontal regeneration. Platelet-rich fibrin (PRF) is known to enhance wound healing through the release of growth factors. This study aimed to observe the outcomes of periodontal surgery when M-MIST was used with or without PRF for the treatment of isolated intrabony defects. Methods: This randomized clinical trial was conducted on 36 systemically healthy patients, who had chronic periodontitis associated with a single-site buccal probing pocket depth (PPD) and clinical attachment level of ≥5 mm. Patients were randomly divided into 2 groups: the test group treated with M-MIST and PRF, and the control group treated with M-MIST alone. The primary periodontal parameters analyzed were PPD, relative attachment level (RAL), and relative gingival margin level. The radiographic parameters analyzed were change in alveolar crest position (C-ACP), linear bone growth (LBG), and percentage bone fill (%BF). Patients were followed up to 6 months post-surgery. Results: Intragroup comparisons at 3 and 6 months showed consistently significant improvements in PPD and RAL in both the groups. In intergroup comparisons, the improvement in PPD reduction, gain in RAL, and the level of the gingival margin was similar in both groups at 3 and 6 months of follow-up. Furthermore, an intergroup comparison of radiographic parameters also demonstrated similar improvements in C-ACP, LBG, and %BF at 6 months of follow-up. Conclusions: M-MIST with or without PRF yielded comparable periodontal tissue healing in terms of improvements in periodontal and radiographic parameters. Further investigation is required to confirm the beneficial effects of PRF with M-MIST.
참고문헌 (33)
- Cortellini P, "Clinical performance of a regenerative strategy for intrabony defects: scientific evidence and clinical experience", J Periodontol, 76, pp.341~350 (2005)
- Cortellini P, "Microsurgical approach to periodontal regeneration. Initial evaluation in a case cohort", J Periodontol, 72, pp.559~569 (2001)
- Cortellini P, "Minimally invasive surgical technique and enamel matrix derivative in intra-bony defects. I: clinical outcomes and morbidity", J Clin Periodontol, 34, pp.1082~1088 (2007)
- Cortellini P, "Improved wound stability with a modified minimally invasive surgical technique in the regenerative treatment of isolated interdental intrabony defects", J Clin Periodontol, 36, pp.157~163 (2009)
- Cortellini P, "Clinical and radiographic outcomes of the modified minimally invasive surgical technique with and without regenerative materials: a randomized-controlled trial in intra-bony defects", J Clin Periodontol, 38, pp.365~373 (2011)
- Mishra A, "Efficacy of modified minimally invasive surgical technique in the treatment of human intrabony defects with or without use of rhPDGF-BB gel: a randomized controlled trial", J Clin Periodontol, 40, pp.172~179 (2013)
- Choukroun J, "An opportunity in perio-implantology: the PRF", Implantodontie, 42, pp.55~62 (2001)
- Dohan DM, "Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 101, pp.e37~e (2006)
- Tatullo M, "Platelet Rich Fibrin (P.R.F.) in reconstructive surgery of atrophied maxillary bones: clinical and histological evaluations", Int J Med Sci, 9, pp.872~880 (2012)
- Dohan DM, "Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates?", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 101, pp.e51~55 (2006)
- Gassling V, "Platelet-rich fibrin membranes as scaffolds for periosteal tissue engineering", Clin Oral Implants Res, 21, pp.543~549 (2010)
- He L, "A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 108, pp.707~713 (2009)
- Patel GK, "Platelet-rich fibrin in regeneration of intrabony defects: a randomized controlled trial", J Periodontol, 88, pp.1192~1199 (2017)
- Sharma A, "Autologous platelet-rich fibrin in the treatment of mandibular degree II furcation defects: a randomized clinical trial", J Periodontol, 82, pp.1396~1403 (2011)
- Aroca S, "Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study", J Periodontol, 80, pp.244~252 (2009)
- Mazor Z, "Sinus floor augmentation with simultaneous implant placement using Choukroun's platelet-rich fibrin as the sole grafting material: a radiologic and histologic study at 6 months", J Periodontol, 80, pp.2056~2064 (2009)
- Armitage GC, "Development of a classification system for periodontal diseases and conditions", Ann Periodontol, 4, pp.1~6 (1999)
- Tonetti MS, "Staging and grading of periodontitis: Framework and proposal of a new classification and case definition", J Periodontol, 89(Suppl 1), pp.S159~S172 (2018)
- Silness J, "Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition", Acta Odontol Scand, 22, pp.121~135 (1964)
- Loe H, "Periodontal disease in pregnancy. I. Prevalence and severity", Acta Odontol Scand, 21, pp.533~551 (1963)
- Schneider CA, "NIH Image to ImageJ: 25 years of image analysis", Nat Methods, 9, pp.671~675 (2012)
- Jayakumar A, "Multi-centre, randomized clinical trial on the efficacy and safety of recombinant human platelet-derived growth factor with β-tricalcium phosphate in human intra-osseous periodontal defects", J Clin Periodontol, 38, pp.163~172 (2011)
- Eickholz P, "Radiographic parameters for prognosis of periodontal healing of infrabony defects: two different definitions of defect depth", J Periodontol, 75, pp.399~407 (2004)
- Saghaei M, "Random allocation software for parallel group randomized trials", BMC Med Res Methodol, 4, pp.26~ (2004)
- Dohan Ehrenfest DM, "Slow release of growth factors and thrombospondin-1 in Choukroun's platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies", Growth Factors, 27, pp.63~69 (2009)
- Blair P, "Platelet alpha-granules: basic biology and clinical correlates", Blood Rev, 23, pp.177~189 (2009)
- Dohan Ehrenfest DM, "In vitro effects of Choukroun's PRF (platelet-rich fibrin) on human gingival fibroblasts, dermal prekeratinocytes, preadipocytes, and maxillofacial osteoblasts in primary cultures", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 108, pp.341~352 (2009)
- Jaquet K, "Erythropoietin and VEGF exhibit equal angiogenic potential", Microvasc Res, 64, pp.326~333 (2002)
- Ribeiro FV, "The role of enamel matrix derivative protein in minimally invasive surgery in treating intrabony defects in single-rooted teeth: a randomized clinical trial", J Periodontol, 82, pp.522~532 (2011)
- Chandradas ND, "Efficacy of platelet rich fibrin in the treatment of human intrabony defects with or without bone graft: a randomized controlled trial", J Int Soc Prev Community Dent, 6, pp.S153~S159 (2016)
- Pradeep AR, "Platelet-rich fibrin combined with a porous hydroxyapatite graft for the treatment of 3-wall intrabony defects in chronic periodontitis: a randomized controlled clinical trial", J Periodontol, 88, pp.1288~1296 (2017)
- Agarwal A, "Platelet rich fibrin combined with decalcified freeze-dried bone allograft for the treatment of human intrabony periodontal defects: a randomized split mouth clinical trail", Acta Odontol Scand, 74, pp.36~43 (2016)
- Lekovic V, "Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects", J Periodontal Res, 47, pp.409~417 (2012)