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Severe periodontitis with tooth loss as a modifiable risk factor for the development of Alzheimer, vascular, and mixed dementia: National Health Insurance Service-National Health Screening Retrospective Cohort 2002–2015

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Purpose: The purpose of this study was to evaluate severe periodontitis with tooth loss as a modifiable risk factor for Alzheimer dementia (AD), vascular dementia (VaD), and mixed dementia (MD) using the National Health Insurance Service-National Health Screening Retrospective Cohort database with long-term follow-up over 14 years. Methods: Multivariate Cox hazards regression analysis was applied to a longitudinal retrospective database, which was updated in 2018, to evaluate the association between severe periodontitis with few remaining teeth and dementia after adjusting for potential risk factors, including sociodemographic factors and comorbid diseases. Results: Among 514,866 individuals in South Korea, 237,940 (46.2%) participants satisfying the inclusion criteria were selected. A total of 10,115 age- and sex-matched participants with severe periodontitis and 10,115 periodontally healthy participants were randomly selected and evenly assigned. The results showed that the risks of AD (hazard ratio [HR], 1.08), VaD (HR, 1.24), and MD (HR, 1.16) were significantly higher in patients with severe periodontitis with 1–9 remaining teeth after adjustment for sociodemographic factors, anthropomorphic measurements, lifestyle factors, and comorbidities. Conclusions: Severe periodontitis with few remaining teeth (1–9) may be considered a modifiable risk factor for the development of AD, VaD, and MD in Korean adults.

Abstract

Purpose: The purpose of this study was to evaluate severe periodontitis with tooth loss as a modifiable risk factor for Alzheimer dementia (AD), vascular dementia (VaD), and mixed dementia (MD) using the National Health Insurance Service-National Health Screening Retrospective Cohort database with long-term follow-up over 14 years. Methods: Multivariate Cox hazards regression analysis was applied to a longitudinal retrospective database, which was updated in 2018, to evaluate the association between severe periodontitis with few remaining teeth and dementia after adjusting for potential risk factors, including sociodemographic factors and comorbid diseases. Results: Among 514,866 individuals in South Korea, 237,940 (46.2%) participants satisfying the inclusion criteria were selected. A total of 10,115 age- and sex-matched participants with severe periodontitis and 10,115 periodontally healthy participants were randomly selected and evenly assigned. The results showed that the risks of AD (hazard ratio [HR], 1.08), VaD (HR, 1.24), and MD (HR, 1.16) were significantly higher in patients with severe periodontitis with 1–9 remaining teeth after adjustment for sociodemographic factors, anthropomorphic measurements, lifestyle factors, and comorbidities. Conclusions: Severe periodontitis with few remaining teeth (1–9) may be considered a modifiable risk factor for the development of AD, VaD, and MD in Korean adults.

참고문헌 (40)

  1. Sposato LA, "Declining incidence of stroke and dementia: coincidence or prevention opportunity?", JAMA Neurol, 72, pp.1529~1531 (2015)
  2. Sorbi S, "EFNS-ENS Guidelines on the diagnosis and management of disorders associated with dementia", Eur J Neurol, 19, pp.1159~1179 (2012)
  3. Alzheimer's Association, "Alzheimer's Association Report : 2017 Alzheimer's disease facts and figures", Alzheimers Dement, 13, pp.325~373 (2017)
  4. Hebert LE, "Alzheimer disease in the United States(2010–2050)estimated using the 2010 census", Neurology, 80, pp.1778~1783 (2013)
  5. Liu CC, "Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy", Nat Rev Neurol, 9, pp.106~118 (2013)
  6. Abbayya K, "Association between periodontitis and Alzheimer's disease", N Am J Med Sci, 7, pp.241~246 (2015)
  7. O'Brien JT, "Vascular dementia", Lancet, 386, pp.1698~1706 (2015)
  8. Iadecola C, "The pathobiology of vascular dementia", Neuron, 80, pp.844~866 (2013)
  9. Schneider JA, "Mixed brain pathologies account for most dementia cases in community-dwelling older persons", Neurology, 69, pp.2197~2204 (2007)
  10. Lee JH, "Predictive data mining for diagnosing periodontal disease : the Korea National Health and Nutrition Examination Surveys(KNHANES V and VI)from 2010 to 2015", J Public Health Dent, 79, pp.44~52 (2019)
  11. Lee JH, "Association between periodontal disease and non-communicable diseases: a 12-year longitudinal health-examinee cohort study in South Korea", Medicine (Baltimore), 96, pp.e7398~ (2017)
  12. Lee JH, "Association of lifestyle-related comorbidities with periodontitis: a nationwide cohort study in Korea", Medicine (Baltimore), 94, pp.e1567~ (2015)
  13. Choi JK, "Effect of periodontitis on the development of osteoporosis : results from a nationwide population-based cohort study(2003–2013)", BMC Womens Health, 17, pp.77~ (2017)
  14. Lee JH, "Association between periodontal disease and prostate cancer : results of a 12-year longitudinal cohort study in South Korea", J Cancer, 8, pp.2959~2965 (2017)
  15. Philip P, "Oral hygiene care status of elderly with dementia and in residential aged care facilities", Gerodontology, 29, pp.e306~e311 (2012)
  16. Ghezzi EM, "Dementia and oral health", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 89, pp.2~5 (2000)
  17. Maurer K, "Dental health in advanced age and Alzheimer's disease : a possible link with bacterial toxins entering the brain", Psychiatry Res Neuroimaging, 282, pp.132~133 (2018)
  18. Riviere GR, "Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer's disease", Oral Microbiol Immunol, 17, pp.113~118 (2002)
  19. Lafon A, "Periodontal disease and stroke : a meta-analysis of cohort studies", Eur J Neurol, 21, pp.1155~1161 (2014)
  20. Lee JH, "National dental policies and socio-demographic factors affecting changes in the incidence of periodontal treatments in Korean : A nationwide population-based retrospective cohort study from 2002-2013", BMC Oral Health, 16, pp.118~ (2016)
  21. Choi S, "Association of chronic periodontitis on Alzheimer's disease or vascular dementia", J Am Geriatr Soc, 67, pp.1234~1239 (2019)
  22. Yoo JJ, "The effect of missing teeth on dementia in older people : a nationwide population-based cohort study in South Korea", BMC Oral Health, 19, pp.61~ (2019)
  23. Dubois B, "Research criteria for the diagnosis of Alzheimer's disease : revising the NINCDS-ADRDA criteria", Lancet Neurol, 6, pp.734~746 (2007)
  24. Langa KM, "Mixed dementia : emerging concepts and therapeutic implications", JAMA, 292, pp.2901~2908 (2004)
  25. Takeuchi K, "Tooth loss and risk of dementia in the community : the Hisayama study", J Am Geriatr Soc, 65, pp.e95~e100 (2017)
  26. Zhu J, "Multiple tooth loss is associated with vascular cognitive impairment in subjects with acute ischemic stroke", J Periodontal Res, 50, pp.683~688 (2015)
  27. Okamoto N, "Relationship of tooth loss to mild memory impairment and cognitive impairment : findings from the Fujiwara-kyo study", Behav Brain Funct, 6, pp.77~ (2010)
  28. Okamoto N, "Tooth loss is associated with mild memory impairment in the elderly : the Fujiwara-kyo study", Brain Res, 1349, pp.68~75 (2010)
  29. 이재홍, "Association between periodontal flap surgery for periodontitis and vasculogenic erectile dysfunction in Koreans", Journal of Periodontal & Implant Science, 47(2), pp.96~105 (2017), 대한치주과학회
  30. Jae-Hong Lee, "Charlson comorbidity index as a predictor of periodontal disease in elderly participants", Journal of Periodontal & Implant Science, 48(2), pp.92~102 (2018), 대한치주과학회
  31. Engelhart MJ, "Inflammatory proteins in plasma and the risk of dementia : the Rotterdam study", Arch Neurol, 61, pp.668~672 (2004)
  32. Sparks Stein P, "Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease", Alzheimers Dement, 8, pp.196~203 (2012)
  33. Foschi F, "Treponema denticola in disseminating endodontic infections", J Dent Res, 85, pp.761~765 (2006)
  34. Miklossy J, "Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes", Neurobiol Aging, 27, pp.228~236 (2006)
  35. D'Aiuto F, "Periodontitis and systemic inflammation : control of the local infection is associated with a reduction in serum inflammatory markers", J Dent Res, 83, pp.156~160 (2004)
  36. Fernando MS, "Vascular pathologies and cognition in a population-based cohort of elderly people", J Neurol Sci, 226, pp.13~17 (2004)
  37. Straka M, "Periodontitis and stroke", Neuroendocrinol Lett, 34, pp.200~206 (2013)
  38. Kalaria RN, "Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors", Lancet Neurol, 7, pp.812~826 (2008)
  39. 이재홍, "Trends in the incidence of tooth extraction due to periodontal disease: results of a 12-year longitudinal cohort study in South Korea", Journal of Periodontal & Implant Science, 47(5), pp.264~272 (2017), 대한치주과학회
  40. 김연태, "Association between health status and tooth loss in Korean adults: longitudinal results from the National Health Insurance Service-Health Examinee Cohort, 2002–2015", Journal of Periodontal & Implant Science, 49(3), pp.158~170 (2019), 대한치주과학회[DOI]

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