Primary somatosensory cortex and periaqueductal gray functional connectivity as a marker of the dysfunction of the descending pain modulatory system in fibromyalgia
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Resting-state functional connectivity (rs-FC) may aid in understanding the link between painmodulating brain regions and the descending pain modulatory system (DPMS) in fibromyalgia (FM). This study investigated whether the differences in rs-FC of the primary somatosensory cortex in responders and non-responders to the conditioned pain modulation test (CPM-test) are related to pain, sleep quality, central sensitization, and the impact of FM on quality of life. Methods: This cross-sectional study included 33 females with FM. rs-FC was assessed by functional magnetic resonance imaging. Change in the numerical pain scale during the CPM-test assessed the DPMS function. Subjects were classified either as non-responders (i.e., DPMS dysfunction, n = 13) or responders (n = 20) to CPM-test. A generalized linear model (GLM) and a receiver operating characteristic (ROC) curve analysis were performed to check the accuracy of the rs-FC to differentiate each group. Results: Non-responders showed a decreased rs-FC between the left somatosensory cortex (S1) and the periaqueductal gray (PAG) (P < 0.001). The GLM analysis revealed that the S1-PAG rs-FC in the left-brain hemisphere was positively correlated with a central sensitization symptom and negatively correlated with sleep quality and pain scores. ROC curve analysis showed that left S1-PAG rs-FC offers a sensitivity and specificity of 85% or higher (area under the curve, 0.78, 95% confidence interval, 0.63–0.94) to discriminate who does/does not respond to the CPM-test. Conclusions: These results support using the rs-FC patterns in the left S1-PAG as a marker for predicting CPM-test response, which may aid in treatment individualization in FM patients.
Abstract
Background: Resting-state functional connectivity (rs-FC) may aid in understanding the link between painmodulating brain regions and the descending pain modulatory system (DPMS) in fibromyalgia (FM). This study investigated whether the differences in rs-FC of the primary somatosensory cortex in responders and non-responders to the conditioned pain modulation test (CPM-test) are related to pain, sleep quality, central sensitization, and the impact of FM on quality of life. Methods: This cross-sectional study included 33 females with FM. rs-FC was assessed by functional magnetic resonance imaging. Change in the numerical pain scale during the CPM-test assessed the DPMS function. Subjects were classified either as non-responders (i.e., DPMS dysfunction, n = 13) or responders (n = 20) to CPM-test. A generalized linear model (GLM) and a receiver operating characteristic (ROC) curve analysis were performed to check the accuracy of the rs-FC to differentiate each group. Results: Non-responders showed a decreased rs-FC between the left somatosensory cortex (S1) and the periaqueductal gray (PAG) (P < 0.001). The GLM analysis revealed that the S1-PAG rs-FC in the left-brain hemisphere was positively correlated with a central sensitization symptom and negatively correlated with sleep quality and pain scores. ROC curve analysis showed that left S1-PAG rs-FC offers a sensitivity and specificity of 85% or higher (area under the curve, 0.78, 95% confidence interval, 0.63–0.94) to discriminate who does/does not respond to the CPM-test. Conclusions: These results support using the rs-FC patterns in the left S1-PAG as a marker for predicting CPM-test response, which may aid in treatment individualization in FM patients.
참고문헌 (50)
- Sawaddiruk P, "Alterations of brain activity in fibromyalgia patients", J Clin Neurosci, 38, pp.13~22 (2017)
- Cagnie B, "Central sensitization in fibromyalgia? A systematic review on structural and functional brain MRI", Semin Arthritis Rheum, 44, pp.68~75 (2014)
- Ali Bidari, "Challenges in fibromyalgia diagnosis: from meaning of symptoms to fibromyalgia labeling", The Korean Journal of Pain, 31(3), pp.147~154 (2018), 대한통증학회
- Apkarian AV, "Human brain mechanisms of pain perception and regulation in health and disease", Eur J Pain, 9, pp.463~484 (2005)
- Coulombe MA, "Intrinsic functional connectivity of periaqueductal gray subregions in humans", Hum Brain Mapp, 37, pp.1514~1530 (2016)
- Coulombe MA, "Lower functional connectivity of the periaqueductal gray is related to negative affect and clinical manifestations of fibromyalgia", Front Neuroanat, 11, pp.47~ (2017)
- Ossipov MH, "Central modulation of pain", J Clin Invest, 120, pp.3779~3787 (2010)
- Staud R, "Abnormal pain modulation in patients with spatially distributed chronic pain : fibromyalgia", Rheum Dis Clin North Am, 35, pp.263~274 (2009)
- Yarnitsky D, "Recommendations on practice of conditioned pain modulation(CPM)testing", Eur J Pain, 19, pp.805~806 (2015)
- Kennedy DL, "Reliability of conditioned pain modulation : a systematic review", Pain, 157, pp.2410~2419 (2016)
- Soldatelli MD, "Mapping of predictors of the disengagement of the descending inhibitory pain modulation system in fibromyalgia : an exploratory study", Br J Pain, 15, pp.221~233 (2021)
- Caumo W, "The Central Sensitization Inventory validated and adapted for a Brazilian population : psychometric properties and its relationship with brain-derived neurotrophic factor", J Pain Res, 10, pp.2109~2122 (2017)
- Baliki MN, "Functional reorganization of the default mode network across chronic pain conditions", PLoS One, 9, pp.e106133~ (2014)
- Wolfe F, "2016 Revisions to the 2010", 2011 fibromyalgia diagnostic criteria, 2016, pp.46, 319~329
- "Post-hoc Statistical Power Calculator for Hierarchical Multiple Regression" (2022)[URL]
- Gomes-Oliveira MH, "Validation of the Brazilian Portuguese version of the Beck Depression Inventory-II in a community sample", Braz J Psychiatry, 34, pp.389~394 (2012)
- Sehn F, "Cross-cultural adaptation and validation of the Brazilian Portuguese version of the pain catastrophizing scale", Pain Med, 13, pp.1425~1435 (2012)
- Kaipper MB, "Evaluation of the structure of Brazilian State-Trait Anxiety Inventory using a Rasch psychometric approach", J Psychosom Res, 68, pp.223~233 (2010)
- Bertolazi AN, "Validation of the Brazilian Portuguese version of the Pittsburgh Sleep Quality Index", Sleep Med, 12, pp.70~75 (2011)
- Whitfield-Gabrieli S, "Conn : a functional connectivity toolbox for correlated and anticorrelated brain networks", Brain Connect, 2, pp.125~141 (2012)
- Bastos AM, "A tutorial review of functional connectivity analysis methods and their interpretational pitfalls", Front Syst Neurosci, 9, pp.175~ (2016)
- Behzadi Y, "A component based noise correction method(CompCor)for BOLD and perfusion based fMRI", Neuroimage, 37, pp.90~101 (2007)
- Grabner G, "Symmetric atlasing and model based segmentation : an application to the hippocampus in older adults", Med Image Comput Comput Assist Interv, 9(Pt 2), pp.58~66 (2006)
- Makris N, "Decreased volume of left and total anterior insular lobule in schizophrenia", Schizophr Res, 83, pp.155~171 (2006)
- Tseng MT, "Determining the neural substrate for encoding a memory of human pain and the influence of anxiety", J Neurosci, 37, pp.11806~11817 (2017)
- Sours C, "Modulation of resting state functional connectivity of the motor network by transcranial pulsed current stimulation", Brain Connect, 4, pp.157~165 (2014)
- Tan Y, "Structural and functional connectivity between the amygdala and orbital frontal cortex in burning mouth syndrome:an fMRI study", Front Psychol, 10, pp.1700~ (2019)
- Sevel LS, "Placebo analgesia enhances descending painrelated effective connectivity : a dynamic causal modeling study of endogenous pain modulation", J Pain, 16, pp.760~768 (2015)
- López-Solà M, "Towards a neurophysiological signature for fibromyalgia", Pain, 158, pp.34~47 (2017)
- Hazlett EA, "Frontal-striatalthalamic mediodorsal nucleus dysfunction in schizophrenia-spectrum patients during sensorimotor gating", Neuroimage, 42, pp.1164~1177 (2008)
- Schreiber KL, "Painful after-sensations in fibromyalgia are linked to catastrophizing and differences in brain response in the medial temporal lobe", J Pain, 18, pp.855~867 (2017)
- Schmidt-Wilcke T, "Resting state connectivity correlates with drug and placebo response in fibromyalgia patients", Neuroimage Clin, 6, pp.252~261 (2014)
- Manning J, "Altered resting-state functional connectivity of the frontal-striatal reward system in social anxiety disorder", PLoS One, 10, pp.e0125286~ (2015)
- Marques AP, "Validation of the Brazilian version of the Fibromyalgia Impact Questionnaire(FIQ)", Rev Bras Reumatol, 46, pp.24~31 (2006)
- Schestatsky P, "Validation of a Brazilian quantitative sensory testing(QST)device for the diagnosis of small fiber neuropathies", Arq Neuropsiquiatr, 69, pp.943~948 (2011)
- Botelho LM, "A framework for understanding the relationship between descending pain modulation, motor corticospinal, and neuroplasticity regulation systems in chronic myofascial pain", Front Hum Neurosci, 10, pp.308~ (2016)
- Amorim P, "Mini International Neuropsychiatric Interview(MINI) : validation of a short structured diagnostic psychiatric interview", Braz J Psychiatry, 22, pp.106~115 (2000)
- Hemington KS, "The periaqueductal gray and descending pain modulation: why should we study them and what role do they play in chronic pain?", J Neurophysiol, 114, pp.2080~2083 (2015)
- Napadow V, "Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity", Arthritis Rheum, 62, pp.2545~2555 (2010)
- Cook DB, "Imaging pain of fibromyalgia", Curr Pain Headache Rep, 11, pp.190~200 (2007)
- Gracely RH, "Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia", Arthritis Rheum, 46, pp.1333~1343 (2002)
- Cardinal TM, "Differential neuroplastic changes in fibromyalgia and depression indexed by up-regulation of motor cortex inhibition and disinhibition of the descending pain system : an exploratory study", Front Hum Neurosci, 13, pp.138~ (2019)
- Davis KD, "Central mechanisms of pain revealed through functional and structural MRI", J Neuroimmune Pharmacol, 8, pp.518~534 (2013)
- Donadel DG, "The mapping of cortical activation by near-infrared spectroscopy might be a biomarker related to the severity of fibromyalgia symptoms", Sci Rep, 11, pp.15754~ (2021)
- Ji G, "Hemispheric lateralization of pain processing by amygdala neurons", J Neurophysiol, 102, pp.2253~2264 (2009)
- Agcaoglu O, "Lateralization of resting state networks and relationship to age and gender", Neuroimage, 104, pp.310~325 (2015)
- Galambos A, "A systematic review of structural and functional MRI studies on pain catastrophizing", J Pain Res, 12, pp.1155~1178 (2019)
- Lazaridou A, "Effects of cognitivebehavioral therapy(CBT)on brain connectivity supporting catastrophizing in fibromyalgia", Clin J Pain, 33, pp.215~221 (2017)
- Cook DB, "Functional imaging of pain in patients with primary fibromyalgia", J Rheumatol, 31, pp.364~378 (2004)
- Gasparin A, "Brain-derived neurotrophic factor modulates the effect of sex on the descending pain modulatory system in healthy volunteers", Pain Med, 21, pp.2271~2279 (2020)