치원성잇몸형성과 오종 -아멜로블라스틴의 제자리 보합법과 면역화학적 발현-
Odontogenic Gingival Epithelial Hamartoma; with Reference to the Expression of Ameloblastin Gene by in situ Hybridization and Immunohistochemistry
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Abstract
Odontogenic gingival epithelial hamartoma (OGEH) is an extremely rare lesion characterized by an abnormal proliferation of odontogenic epithelium. This lesion is thought to arise from the rest of the dental lamina lying dormant in the gingival tissue after odontogenesis. Distinguishing OGEH from the granular cell variant of ameloblastoma and central odontogenic fibroma is important. To date, only eleven cases have been reported, and its pathogenesis remains unclear. We report here on a case of OGEH, where the epithelial strands in the lesion were conspicuously positive for the antisera of cytokeratin 19 and ameloblastin. Tumor cells intensely expressed ameloblastin mRNA by in situ hybridization. To the best of our knowledge, this is the first case of OGEH to which ameloblastin immunohistochemical stain and in situ hybridization were applied. Although our study is limited to a single case, the coexpression of cytokeratin 19 and ameloblastin might indicate the origin and specific cytodifferentiation of OGEH is quite different and unique, when contrasted to other odontogenic tumors.
참고문헌 (14)
- "report of case", pp.932~5
- "An ameloblastoma and a hamartoma of the dental laminain two siblings", pp.697~701
- "Odontogenic epithelial hamartomas in periodontalstructures", pp.92~7
- "Odontogenic epithelial hamartoma of the gingiva", kita(m), pp.452~7
- "Cytoskeletal gene expression in normal and neoplastic human odontogenicepithelia", pp.688~701
- "Expression ofcytokeratins in human enamel organ", 108, pp.43~47 (2000)
- "Full-length sequence, localization, and chromosomal mappingof ameloblastin.", 271, pp.4431~4435 (1996)
- "Reportof two undescribed cases with features of granular cell ameloblastomaand plexiform granular cell odontogenic tumor", pp.134~8 (1993), J Nihon Univ SchDent 1993; 35
- "Report of 5 cases", pp.134~8
- "Odontogenic fibroma", pp.293~6 (1999)
- "Atlas of tumor pathology Intraosseous and parosteal tumors of the jaws DC;Armed Forces of Institute of Pathology", pp.110~2 (1987)
- "Histogenesis of odontogenictumors", pp.569~81
- "Histopathologic findings in third molar opercula", pp.215~24
- "Peripheral ameloblastomawith potentially malignant features: report of a case with specialregard to its keratin profile", 30, pp.494~498 (2001)