본문 바로가기
KERD
논문KCI 등재

자궁목 병변에서 p16, p53 단백과 Ki-67의 발현

Studies on the Expression of the p16 (INK4A), p53, and Ki-67 Labeling Index in Inflammatory and Neoplastic Diseases of the Uterine Cervix

이정희|신정규|고경혁|김활웅|이종실
대한병리학회|2004.08|Journal of Pathology and Translational Medicine|제38권 제4호|pp. 238-243

2

조회

0

다운로드

2

인용

0

참고문헌

주제분류병리학

초록

Abstract

Background : Prior studies of p16, p53, and Ki-67 expression have suggested that these markers may be preferentially expressed in cervical neoplasms. The purpose of this study was to assess the expression and clinical significance of p16, p53 proteins, and the Ki-67 labeling index in the cervical lesions. Methods : We analyzed 54 uterine cervical specimens obtained by surgical biopsy. The expression of p16, p53 proteins, and Ki-67 was evaluated by immunohistochemical methods. The immunohistochemical findings were then correlated with the histologic diagnosis. Results : Positive scores for p16, p53, and Ki-67 were seen in 75% (6/8), 0% (0/8), and 13% (1/8) of low grade intraepithelial lesions (LSIL), respectively, and 100% (23/23), 17% (4/23), and 74% (17/23) of high grade intraepithelial lesions (HSIL), respectively, and 100% (10/10), 20% (2/10), and 70% (7/10) of invasive squamous cell carcinomas, respectively. Both normal epithelium and inflammatory lesions scored negative for these three markers in all of the 13 cases. p16 and Ki-67 expression correlated with the severity of uterine cervix lesions. Conclusions : p16 and Ki-67 are complementary surrogate biomarkers for cervical squamous intraepithelial neoplasia. However, immunohistochemical expression for p53 has no correlation with the grade of cervical squamous intraepithelial neoplasia.

참고문헌 (27)

  1. "Expression status of p16protein is associated with human papillomavirus oncogenic potentialin cervical and genital lesions", 153, pp.1741~1748 (1998)
  2. "Overexpression of p16 as a specific marker for dysplastic and neoplastic epithelialcells of the cervix uteri", 92, pp.276~284 (2001)
  3. "p16INK4a immunohistochemistryimproves interobserver agreement in the diagnosis of cervicalintraepithelial neoplasia", 26, pp.1389~1399 (2002)
  4. "cyclin E,and p16INK4 arecomplimentary surrogate biomarkers for human papilloma virusrelatedcervical neoplasia", 25, pp.884~891 (2001)
  5. "Analysis of Expression of p63 in cervicalneoplasia comparing with other immunohistochemical markers", 37, pp.333~341 (2003)
  6. "Immunohistochemical expression ofp53, p21,and mdm2 proteins in human papillomavirus positive andnegative invasive uterine cervical carcinomas.", 35, pp.212~219 (2001)
  7. "Mutations of p16Ink4", CKSN2and p15Ink4B, pp.1995, 55[DOI]
  8. "Codeletion of p15 andp16 genes in primary non-small cell lung carcinoma.", 55, pp.2968~2971 (1995)
  9. "Mutation frequency of the p16", CDKN2 gene in primary cancers in the upper digestive tract, 1995, pp.55, 3421~3423
  10. "E2F; a link between the Rb tumor suppressor protein andviral oncoproteins", pp.424~429 (1992)
  11. "The HPV-16E6 and E6-AP complex functions as a ubiquitin protein ligase in theubiquination of p53", 75, pp.495~505
  12. "Human papillomaviruses and cervical neoplasia II.Interaction of HPV with other factors.", 48, pp.1~6 (1995)
  13. "Monoclonal antibody Ki-67, its use in histopathology", mo(clonal antibody ki-67), pp.884~90
  14. "Prognostic significance of Ki-67 nuclear proliferativeantigen and p53 expression in follicular and diffuselarge B-cell lymphoma", 18, pp.15~22 (2001)
  15. "Viraland histopathologic correlates of MN and MIB-1 expression in cervicalintraepithelial neoplasia.", 27, pp.234~239 (1996)
  16. "Assessment of Ki-67 antigen immunostaining in squamous intraepitheliallesions of the uterine cervix Correlation with the histologicgrade and human papillomavirus type", 104, pp.154~160 (1995)
  17. "p16INK4a is a useful markerfor the diagnosis of adenocarcinoma of the cervix uteri and its precursors", 27, pp.187~193 (2003)
  18. "Alterations of CDKN2 gene in paraffin-embedded tumor tissues of human stomach,lung,cervix and liver cancers.", 30, pp.109~114 (1998)
  19. "Immunohistochemicaloverexpression of p16 protein associated with intactretinoblastoma protein expression in cervical cancer and cervicalintraepithelial neoplasia", 48, pp.580~585 (1998)
  20. "p53 Expression in carcinomaof the cervix", pp.971~974 (1996)
  21. "An immunohistochemical study of p53protein in cervical intraepithelial neoplasia and squamous cell carcinoma", 28, pp.17~19 (1996)
  22. "p53 immunoreactivityin inflammatory and neoplastic diseases of the uterine cervix", 169, pp.425~430 (1993)
  23. "Prognostic valueof p53 expression in stage IB1 cervical carcinoma", 49, pp.266~271 (2000)
  24. "The possiblerole of p53 and bcl-2 expression in cervical carcinomas and their premalignantlesions", 77, pp.129~136 (2000)
  25. "Prognostic valueof bcl-2, p53,and Ki-67 in invasive squamous carcinoma of the uterinecervix", 21, pp.267~272 (2002)
  26. "The status ofhuman papillomavirus and tumor suppressor genes p53 and p16in carcinomas of uterine cervix from India", 69, pp.205~209 (1998)
  27. "p53 status and human papillomavirus infection inThai women with cervical carcinoma", 31, pp.66~71 (2000)

관련 논문AI추천

인유두종 바이러스의 감염 또는 감염되지 않은 자궁 경부 이형성증에서 p53 및 Ki-67의 발현김태전, 이훈택, 최숙경, 홍승복대한임상검사과학회 · 대한임상검사과학회지2004 · 제36권 제2호The Utility of p16INK4a and Ki-67 as a Conjunctive Tool in Uterine Cervical Lesions김인선, 김철환, 김현철, 김혜선, 이상호대한병리학회 · Journal of Pathology and Translational Medicine2012 · 제46권 제3호자궁경부상피의 암화과정에 있어서 Cytokeratins 및 Ki-67의 발현과 인유두종 바이러스 16, 18형의 감염고석봉, 설의석, 이태성, 한치동대한산부인과학회 · Obstetrics & Gynecology Science2003 · 제46권 제6호자궁경부 이형성증과 암의 진단을 위한 액상세포 검체에서 p16INK4a/Ki-67 이중면역염색의 평가김욱연, 성미희, 신민식, 오서영, 이훈택대한임상검사과학회 · 대한임상검사과학회지2015 · 제47권 제3호자궁경부 상피내종양에서 p16INK4a와 pRb의 이상 발현과고위험 군 인유두종바이러스 감염 및 재발의상관성에 관한 연구김상운, 김성훈, 김영태, 김재욱, 김재훈, 김혜연, 남은지, 윤보성, 조남훈대한산부인과학회 · Obstetrics & Gynecology Science2006 · 제49권 제7호자궁경부암 및 자궁경부 상피내 종양 분류의 생물학적 표식자로서의 Ki-67, p63, p53, 및 p27 단백의 표현양상김성희, 김영재, 박문향, 이홍주, 조삼현대한산부인과학회 · Obstetrics & Gynecology Science2007 · 제50권 제4호

이 간행물의 다른 논문 (13건)

위 샘암종에서 cyclin E, p53, E-cadherin 및 β-catenin 발현의 의의이미자, 서재홍, 현용배pp. 213-220육종에서 p53, c-kit과 CD34의 발현에 대한 조직 미세배열을 이용한 연구유진영, 박경신, 강석진, 강창석pp. 221-227내분비계 장애물질에 의한 고환 내 세포손상에서 아포토시스 관련 분자들의 변화강창석, 이권행, 왕은휘, 정은선, 양기화, 이진숙, 최영진pp. 228-237간세포암종에서 편평세포 성장인자와 c-ErbB-2의 발현 부재문우성, 박호성, 손현진, 박민영pp. 244-248비장절제가 바륨 급성 중독에 미치는 영향설혜정, 강대영pp. 249-257
원문 보기