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논문KCI 등재

난소종양에서의 Melanoma Antigen Genes (MAGE)와 Synovial Sarcoma on X chromosome (SSX)의 발현

Expression of Melanoma Antigen Gene (MAGE) and Synovial Sarcoma on X chromosome (SSX) in Ovarian Tumors

박종욱|김원|장희경|박진경|전창호|김광휘|김영옥
대한병리학회|2004.12|Journal of Pathology and Translational Medicine|제38권 제6호|pp. 372-377

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주제분류병리학

초록

Abstract

Background : Several cancer-testis antigen genes or gene families have been isolated to date, including Melanoma Antigen Gene (MAGE) and Synovial Sarcoma on X chromosome (SSX). This study attempted to investigate the possibility of immunotherapy for ovarian cancer and to explore the prevalence of the expression of MAGE and SSX. Methods : The fresh tissue samples were obtained from 5 cases of normal ovaries, 6 cases of non-neoplastic disease, 21 cases of benign ovarian tumors, and 12 cases of malignant ovarian tumors. The expression of MAGE A1-6 and SSX 1-9 was detected by nested reverse transcription-polymerase chain reaction using each common primers sets for MAGE A1-6 and SSX 1-9. Results : The expression rate of MAGE 1-6 mRNA was 23.0% (5/21) for the benign ovarian tumors and 91.7% (11/12) for the malignant ovarian tumor, whereas the normal ovaries (0/5) and non-neoplastic ovarian tissues (0/6) did not express MAGE (p<0.05). The expression rate of SSX was 40.0% (2/5) for the normal ovaries, 23.0% (5/21) for the benign ovarian tumors, and 33.3% (4/12) for the malignant ovarian tumors, while the non-neoplastic ovarian tissues showed no expression of SSX (p>0.05). A relationship between the two genes was not observed (kappa coefficient=0.32). Conclusions : These results suggest that the gene products of MAGE and SSX can be useful for the immunotherapy of ovarian cancer patients and that MAGE can be a more promising target than SSX from the viewpoint of applicability and cancer-specificity.

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관련 논문AI추천

Detection of MAGE and SSX Gene Expressions by RT-nested PCR Using Common Primers in Head and Neck Cancer김동은, 송달원, 신승진, 이강대, 정승곤대한이비인후과학회 · Clinical and Experimental Otorhinolaryngology2008 · 제1권 제2호대장의 관상샘종 및 관상샘암종에서의 Melanoma Antigen Gene A1-6의 발현구자영, 박무인, 박진경, 박희승, 엄정섭, 장희경, 정민정대한소화기내시경학회 · Clinical Endoscopy2003 · 제27권 제6호악성 흑색종에서의 MLH1, MSH2의 발현김민관, 김상윤, 김영진, 남순열, 이윤세, 최승호, 허주령대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2003 · 제46권 제5호난소 상피암에서 현미부수체 불안정성 분석강현정, 김익두, 김지연, 서순정, 설미영, 신동훈, 최경운, 최효선대한병리학회 · Journal of Pathology and Translational Medicine2007 · 제41권 제6호폐암환자의 경기관지 생검조직에서 MAGE 및 GAGE 발현김지혜, 김지호, 박기룡, 옥철호, 장태원, 정만홍, 조현명대한내과학회 · 대한내과학회지2002 · 제62권 제1호난소의 양성, 경계성 및 악성 상피성 종양에서 성 호르몬 수용체인 에스트로젠 수용체-α와 -β, 프로제스테론 수용체 A, B 아형 및 안드로젠 수용체의 발현과 생물학적인 의의에 관한 연구김경태, 이정한대한산부인과학회 · Obstetrics & Gynecology Science2005 · 제48권 제6호

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