Expression of Vascular Endothelial Growth Factors A, C and D in GastricAdenocarcinoma
Expression of Vascular Endothelial Growth Factors A, C and D in Gastric Adenocarcinoma
2
조회
0
다운로드
1
인용
0
참고문헌
초록
Abstract
Background : Vascular endothelial growth factor (VEGF)-C and VEGF-D are novel growth factors that regulate lymphatic vessel growth. This study was designed to examine whether the expression of three VEGF family members, VEGF-A, VEGF-C and VEGF-D are associated with the clinicopathologic parameters, especially with lymph node metastasis, in advanced gastric carcinomas. Methods : Immunohistochemical staining was performed for VEGF-A, VEGF-C, and VEGF-D in the surgically resected specimens from 102 patients with advanced gastric carcinoma. The mRNA expressions of the three VEGF family members were assessed in 16 cases of tumor tissues and their corresponding non-neoplastic tissues. Results : Of the 102 gastric carcinomas, 74 (73%), 82 (80%), and 34 (33%) cases showed cytoplasmic immuno-reactivity for VEGF-A, VEGF-C and VEGF-D, respectively. Both VEGF-A and VEGF-C expressions were associated with lymphatic invasion and lymph node metastasis (p<0.05), but the VEGF-D expression was not associated with them (p>0.05). In the tumor tissue, VEGF-C mRNA expression was greater, while VEGF-D mRNA expression was lower than in the non-neoplatic tissue adjacent to the tumor. Conclusions : VEGF-A and VEGF-C may play important roles for the lymphatic spread of gastric carcinoma. We suggest that neutralizing both VEGF-A and VEGF-C may be reguired to block lymph node metastasis.
참고문헌 (25)
- "Tumor cells secrete a vascular permeability factor that promotesaccumulation of ascites fluid", 219, pp.983~5 (1983)
- "Vascular endothelial growth factor receptorsin the regulation of angiogenesis and lymphangiogenesis", 19, pp.5598~605 (2000)
- "is a ligand for the Flt4", 15, pp.290~3 2 8
- "Expression of the fmsliketyrosine kinase 4 gene becomes restricted to lymphatic endotheliumduring development", 92, pp.3566~70 (1995)
- "is a ligand for the tyrosine kinases VEGF receptor2", pp.548~53
- "Transport of molecules in the tumor interstitium:a review", 47, pp.3039~51 (1987)
- "Angiogenesis in cancer and other diseases", 407, pp.249~57 (2000)
- "Role of vascular endothelialgrowth factor C expression in the development of lymph node metastasisin gastric cancer", 5, pp.1823~9 (1999), Clin Cancer Res
- "Prognostic significanceof the expression of vascular endothelial growth factor(VEGF)and VEGF-C in gastric carcinoma", 78, pp.132~7 (2001)
- "Interleukin 8 and vascular endothelialgrowth factor - prognostic factors in human gastric carcinomas", 37, pp.1482~7 (2001)
- "Vascular endothelial growth factor is a marker of tumor invasionand metastasis in squamous cell carcinomas of the head andneck", 5, pp.775~82 (1999), Clin Cancer Res
- "Absence offunctional lymphatics within a murine sarcoma:a molecular andfunctional evaluation", 60, pp.4324~7 (2000)
- "VEGF-C induced lymphangiogenesis is associated withlymph node metastasis in orthotopic MCF-7 tumors", 98, pp.946~51
- "Expression of vascularendothelial growth factor(VEGF)family members in breast cancer", 90, pp.977~81 (1999)
- "Vascular endothelial growthfactor-C(VEGF-C)expression in human colorectal cancer tissues", 83, pp.887~91 (2000)
- "Increased vascularendothelial growth factor and vascular endothelial growthfactor-c and decreased nm23 expression associated with microdisseminationin the lymph nodes in stage I non-small cell lung cancer", 119, pp.804~13 (2000)
- "Vascular endothelial growthfactor-C expression in human prostatic carcinoma and its relationshipto lymph node metastasis", 80, pp.309~13 (1999)
- "The short form of the alternativelyspliced flt-4 but not its ligand vascular endothelial growthfactor C is related to lymph node metastasis in human breast cancers", 6, pp.4278~86 (2000), Clin Cancer Res
- "Lymphatic function,lymphangiogenesis,andcancer metastasis", 55, pp.92~9 (2001)
- "Identification ofa c-fos-induced gene that is related to the platelet-derived growthfactor", vascular endothelial growth factor family, 1996, pp.93, 11675~80
- "VEGF-D promotes themetastatic spread of tumor cells via the lymphatics", 7, pp.186~91 (2001)
- "Vascular endothelial growthfactor-D expression is an independent prognostic marker for survivalin colorectal carcinoma", 62, pp.1669~75 (2002)
- "and D andtheir relationships to lymph node status in lung adenocarcinoma", 6, pp.2431~9 (2000), Expressionof vascular endothelial growth factors A Clin Cancer Res 2000
- "VEGF-A,VEGF-C,andVEGF-D in colorectal cancer progression", 3, pp.420~7 (2001)
- "Expression of vascularendothelial growth factor family members in head and neck squamouscell carcinoma correlates with lymph node metastasis", 92, pp.556~68 (2001)