비강 및 부비동에 발생한 저악성 선암종: 임상 병리학적 면역조직화학적 소견에 관한 3예 보고
Sinonasal Low-Grade Adenocarcinoma: Report of Three Cases with the Clinicopathologic andImmunohistochemical Findings
1
조회
0
다운로드
1
인용
0
참고문헌
초록
Abstract
Low-grade adenocarcinomas that primarily arise within the sinonasal tract are uncommon tumors. We report here on three cases of primary sinonasal low-grade adenocarcinomas. The patients were 2 females and 1 male with ages of 48, 57 and 64, respectively. Microscopically, the tumors had a well developed tubulopapillary growth pattern that consisted of columnar or pseudostratified cells with eosinophilic cytoplasm, round to oval nuclei and rare mitotic activity. On immunohistochemistry, the tumor cells were strongly positive for cytokeratin 7, but they were negative for cytokeratin 20, CDX-2 and p53. The Ki-67 labeling index was very low (mean: 1.9%). Two patients developed recurrent tumors at the primary site after the initial surgery, but all the patients are presently alive without metastasis 6 years 8 months, 8 years 8 months, and 11 months after the initial diagnosis. When considering the progress of these tumors, we think that it’s important to understand the pathology of this entity to avoid underdiagnosis because a complete excision is required for effective treatment.
참고문헌 (19)
- "Adenocarcinoma. In: Barnes L,Eveson JW, Reichart P, Sidransky D. World health organizationclassification of tumours", pp.20~23 (2005), IARC
- "Intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses", 10, pp.192~202 (1986)
- "Expression pattern of CK7, CK20, CDX-2, and villin in intestinal-type sinonasal adenocarcinoma", 57, pp.932~937 (2004)
- "Immunophenotypic differences between intestinal-type and low-grade papillary sinonasal adenocarcinomas:an immunohistochemical study of 22 cases utilizing CDX2 and MUC2", 28, pp.1026~1032 (2004)
- "Sinonasal intestinaltype adenocarcinoma:immunohistochemical profile and comparison with colonic adenocarcinoma", 8, pp.421~426 (1995)
- "Adenocarcinoma of nasal and paranasal cavities", 77, pp.625~33 (1963)
- "Adenocarcinoma of the ethmoid sinuses:a review of 28 cases with special reference to wood dust exposure", 54, pp.482~8 (1984)
- "Enteric-type adenocarcinoma of the nasal cavity", 54, pp.855~60 (1984)
- "Adenocarcinomas of the inner nose after exposure to wood dust", 245, pp.1~15 (1988)
- "Histologic classification of sinonasal intestinal-type adenocarcinoma", 15, pp.368~75 (1991)
- "Sinonasal tubulopapillary lowgrade adenocarcinoma. Histopathological, immunohistochemical and ultrastructural features of poorly recognised entity", 443, pp.152~158 (2003)
- "CDX-2 homeobox gene expression", 27, pp.1390~1391 (2003)
- "The Cdx-1 and Cdx-2 homeobox genes in the intestine", 76, pp.957~969 (1998)
- "Terminal tubulus adenocarcinoma of the nasal seromucous glands", 241, pp.183~93 (1985)
- "Sinonasal adenocarcinoma:evidence for histogenetic divergence of the enteric and nonenteric phenotypes", 34, pp.1101~1107 (2003)
- "Genetic analysis of sinonasal adenocarcinoma phenotypes:distinct alterations of histogenetic significance", 18, pp.315~319 (2005)
- "Prognostic significance of microvessel density and vascular endothelial growth factor expression in sinonasal carcinomas", 37, pp.391~400 (2006)
- "Mucosal origin of sinonasal tract adenomatous neoplasms", 2, pp.365~71 (1989)
- "Salivary-type neoplasms of the sinonasal tract", 100, pp.691~4 (1991)