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담낭암종에서의 p53, Heat Shock Protein 70과 TopoisomeraseIIα 의 발현

p53, Heat Shock Protein 70 and Topoisomerase II Expressionin Gallbladder Carcinoma

정진숙|노미숙|김대철
대한병리학회|2006.12|Journal of Pathology and Translational Medicine|제40권 제6호|pp. 432-438

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초록

Abstract

The present study was designed to investigate the expression of p53, Heat Shock Protein 70 (HSP70), and Topoisomerase (Topo) IIα in the preneoplastic lesions and carcinomas of the gallbladder (GB) and to assess the correlation between the expression of these proteins and the clinicopathologic parameters by performing immunohistochemistry. Methods : The immunohistochemical expressions of p53, HSP70 and Topo IIα were evaluated in 38 gallbladder carcinomas and 3 adenomas. Fifteen CISs and 8 dysplasias that were located adjacent to invasive carcinomas were also studied. Results : A p53 expression was identified in 22 (57.9%) of the 38 GB carcinomas, in 9 (64.3%) of 14 CISs, and in none of the 8 dysplasias and 3 adenomas. A HSP70 expression was found in 11 (29%) of the 38 carcinomas, in 11 (78.6%) of 14 CISs, and in 4 (57.2%) of 7 dysplasias. A Topo IIα expression was present in 36 (94.7%) of the 38 carcinomas, in 13 (92.9%) of 14 CISs, in 7 (100%) of 7 dysplasias and in 3 (100%) of 3 adenomas. p53 overexpression was related to the T stage of the primary tumor, while HSP70 and Topo IIα were not related to any of the clinicopathologic parameters. Conclusion : p53 may be involved in GB carcinogenesis and in the progression of cancer. p53 may be also helpful for making the differential diagnosis between dysplasia and CIS. A further large study is needed to better elucidate the roles of HSP70 and Topo IIα in GB carcinogenesis.

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