미만성 거대세포 림프종 환자의 비장에 생긴 염증성 거짓종양양 림프소포 가지세포 종양에 관한 증례 보고 및 문헌고찰
Epstein-Barr virus-associated Inflammatory PseudotumorlikeFollicular Dendritic Cell Tumor in the Spleen of a Patientwith Diffuse Large B Cell Lymphoma: A Case Report andReview of the Literature
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Abstract
We report a case of an Epstein-Barr virus (EBV)-associated inflammatory pseudotumor-like follicular dendritic cell tumor (IPT-like FDC tumor). The tumor occurred in the spleen of a 64- year-old woman with a history of a diffuse large B-cell lymphoma (DLBCL) of neck nodes that presented four years ago. The splenectomy specimen revealed a 5 cm-sized, tan-colored and well-circumscribed mass. Histologically, spindle or ovoid cells with large vesicular nuclei were admixed with abundant inflammatory cells. Immunohistochemically, spindle cells were positive for FDC marker CD35, but negative for CD20, CD30 and ALK. EBV was detected almost exclusively in spindle cells by EBER in situ hybridization. IPT-like FDC tumors are rare, and are recognized as a distinctive clinicopathologic variant of FDC tumors. Among only 18 similar cases reported in the English language literature, the present case is the first case of a patient with a history of DLBCL.
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