Primary Synovial Sarcoma of the Kidney: A Case Report and Literature Review
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Synovial sarcoma is a rare renal neoplasm that is not easy to diagnose unless SYT-SSX fusion transcripts are identified. We report here on a case of primary renal synovial sarcoma in a 35-year-old woman. A mass was discovered by accident in the lower part of the right kidney when ultrasonography was performed, and it was removed via radical nephrectomy. Grossly, the tumor was a homogeneously tan-brown soft mass that measured 4.5×3.2×3.0 ㎝, and it was encircled by a well-defined cystic space. The lesion exhibited hypercellularity of the oval or short spindle cells that were arranged in various solid sheets or intersecting fascicles. Immunohistochemically, the tumor showed diffuse positivity for vimentin, bcl-2 and CD99, and it showed focal positivity for epithelial membrane antigen. The SYT-SSX fusion transcripts were detected by reverse transcription-polymerase chain reaction (RT-PCR). Synovial sarcoma should be considered in the differential diagnosis when a spindle cell neoplasm is encountered in the kidney.
Abstract
Synovial sarcoma is a rare renal neoplasm that is not easy to diagnose unless SYT-SSX fusion transcripts are identified. We report here on a case of primary renal synovial sarcoma in a 35-year-old woman. A mass was discovered by accident in the lower part of the right kidney when ultrasonography was performed, and it was removed via radical nephrectomy. Grossly, the tumor was a homogeneously tan-brown soft mass that measured 4.5×3.2×3.0 ㎝, and it was encircled by a well-defined cystic space. The lesion exhibited hypercellularity of the oval or short spindle cells that were arranged in various solid sheets or intersecting fascicles. Immunohistochemically, the tumor showed diffuse positivity for vimentin, bcl-2 and CD99, and it showed focal positivity for epithelial membrane antigen. The SYT-SSX fusion transcripts were detected by reverse transcription-polymerase chain reaction (RT-PCR). Synovial sarcoma should be considered in the differential diagnosis when a spindle cell neoplasm is encountered in the kidney.
참고문헌 (20)
- Erturhan S, "Primary synovial sarcoma of the kidney: use of PET", CT in diagnosis and follow-up, 2008, pp.22, 225~229
- Argani P, "Primary renal synovial sarcoma:molecular and morphologic delineation of an entity previously included among embryonal sarcomas of the kidney", Am J Surg Pathol, 24, pp.1087~1096 (2000)
- Kim DH, "Primary synovial sarcoma of the kidney", Am J Surg Pathol, 24, pp.1097~1104 (2000)
- Koyama S, "Primary synovial sarcoma of the kidney: report of a case confirmed by molecular detection of the SYT-SSX2 fusion transcripts", Pathol Int, 51, pp.385~391 (2001)
- Chen S, "Primary synovial sarcoma of the kidney: a case report with literature review", Int J Surg Pathol, 9, pp.335~339 (2001)
- Dai YC, "A rare synovial sarcoma of the kidney exhibiting translocation (X;18) and SYT-SSX2 fusion gene", Zhonghua Yi Xue Za Zhi, 65, pp.293~297 (2002)
- Bella AJ, "Primary synovial sarcoma of the kidney diagnosed by molecular detection of SYT-SSX fusion transcripts", J Urol, 168, pp.1092~1093 (2002)
- Vesolius Z, "Fine needle aspiration biopsy of primary renal synovial sarcoma: a case report", Acta Cytol, 47, pp.668~672 (2003)
- Moch H, "Primary renal synovial sarcoma: a new entity in the morphological spectrum of spindle cell renal tumors", Pathologe, 24, pp.466~472 (2003)
- Chen PC, "Primary renal synovial sarcoma with inferior vena cava and right atrium invasion", Int J Urol, 10, pp.657~660 (2003)
- Tornkvist M, "A novel case of synovial sarcoma of the kidney: impact of SS18", SSX analysis of renal hemangiopericytoma-like tumors, 2004, pp.13, 47~51
- Jun SY, "Synovial sarcoma of the kidney with rhabdoid features: report of three cases", Am J Surg Pathol, 28, pp.634~637 (2004)
- Shannon BA, "Primary renal synovial sarcoma confirmed by cytogenetic analysis: a lesion distinct from sarcomatoid renal cell carcinoma", Arch Pathol Lab Med, 129, pp.238~240 (2005)
- Perlmutter AE, "Primary synovial sarcoma of the kidney", Int J Urol, 12, pp.760~762 (2005)
- Pala$u L MA, "Primary synovial sarcoma of the kidney with rhabdoid features", Int J Surg Pathol, 15, pp.421~428 (2007)
- Mirza M, "Primary synovial sarcoma of the kidney", Urology, 72, pp.716~ (2008)
- Chung SD, "Primary synovial sarcoma of the kidney", J Formos Med Assoc, 107, pp.344~347 (2008)
- Gabilondo F, "Primary synovial sarcoma of the kidney: corroboration with in situ polymerase chain reaction", Ann Diagn Pathol, 12, pp.134~137 (2008)
- Tsuji S, "Detection of SYT-SSX fusion transcripts in synovial sarcoma by reverse transcription-polymerase chain reaction using archival paraffin-embedded tissues", Am J Pathol, 153, pp.1807~1812 (1998)
- Turc-Carel C, "Translocation X;18 in synovial sarcoma", Cancer Genet Cytogenet, 23, pp.93~ (1986)