Systemic Plasmacytosis - A Case Report with a Review of the Literature -
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Systemic plasmacytosis is an uncommon disorder characterized by widely disseminated macular skin eruptions composed of polyclonal lymphoplasmacytic infiltrates associated with variable extracutaneous involvement. An aggressive clinical course has been observed in a small number of patients, but most cases have followed chronic and benign clinical course without spontaneous remission. Previously reported cases of this entity have been described almost exclusively in Japanese patients. We recently experienced a case of systemic plasmacytosis in a 48-year-old Korean female patient. Initial skin biopsy specimen revealed patchy perivascular and periadnexal infiltrates of mature plasma cells. Serum immunoelectrophoresis revealed polyclonal hypergammaglobulinemia, and polyclonal plasmacytosis was noted on the subsequent biopsy specimens of left supraclavicular and axillary lymph nodes. Multiple tiny pulmonary nodules appeared six years after the initial cutaneous presentation and were found to be of the same histologic appearance. We herein report a rare case of systemic plasmacytosis with a review of the literature.
Abstract
Systemic plasmacytosis is an uncommon disorder characterized by widely disseminated macular skin eruptions composed of polyclonal lymphoplasmacytic infiltrates associated with variable extracutaneous involvement. An aggressive clinical course has been observed in a small number of patients, but most cases have followed chronic and benign clinical course without spontaneous remission. Previously reported cases of this entity have been described almost exclusively in Japanese patients. We recently experienced a case of systemic plasmacytosis in a 48-year-old Korean female patient. Initial skin biopsy specimen revealed patchy perivascular and periadnexal infiltrates of mature plasma cells. Serum immunoelectrophoresis revealed polyclonal hypergammaglobulinemia, and polyclonal plasmacytosis was noted on the subsequent biopsy specimens of left supraclavicular and axillary lymph nodes. Multiple tiny pulmonary nodules appeared six years after the initial cutaneous presentation and were found to be of the same histologic appearance. We herein report a rare case of systemic plasmacytosis with a review of the literature.
참고문헌 (20)
- Leonard AL, "Cutaneous and systemic plasmacytosis", J Am Acad Dermatol, 56(2 Suppl), pp.S38~S40 (2007)
- Ma HJ, "Cutaneous and systemic plasmacytosis: a Chinese case", J Dermatol, 35, pp.536~540 (2008)
- Miyagawa-Hayashino A, "High ratio of IgG4-positive plasma cell infiltration in cutaneous plasmacytosis: is this a cutaneous manifestation of IgG4-related disease", Hum Pathol, 40, pp.1269~1277 (2009)
- Watanabe S, "Systemic plasmacytosis: a syndrome of peculiar multiple skin eruptions, generalized lymphadenopathy, and polyclonal hypergammaglobulinemia", Arch Dermatol, 122, pp.1314~1320 (1986)
- Lee DW, "Systemic plasmacytosis: a case which improved with melphalan", J Dermatol, 22, pp.205~209 (1995)
- 이덕우, "비전형적인 임상양상을 보인 피부 및 전신적 형질세포증 1예", 대한피부과학회지, 47(5), pp.558~561 (2009), 대한피부과학회
- Uhara H, "Primary cutaneous plasmacytosis: report of three cases and review of the literature", Dermatology, 189, pp.251~255 (1994)
- Carey WP, "Systemic plasmacytosis with cutaneous manifestations in a white man: successful therapy with cyclophosphamide", prednisone, 1998, pp.38, 629~631
- Gilliam AC, "Isolated benign primary cutaneous plasmacytosis in children: two illustrative cases", Arch Dermatol, 145, pp.299~302 (2009)
- Amin HM, "Cutaneous and systemic plasmacytosis in a patient of Asian descent living in the United States", Am J Dermatopathol, 24, pp.241~245 (2002)
- Nitta Y, "Case of malignant lymphoma associated with primary systemic plasmacytosis with polyclonal hypergammaglobulinemia", Am J Dermatopathol, 19, pp.289~293 (1997)
- Tada Y, "Plasmacytosis: systemic or cutaneous, are they distinct", Acta Derm Venereol, 80, pp.233~235 (2000)
- Yamamoto T, "Intralesional steroid-therapy-induced reduction of plasma interleukin-6 and improvement of cutaneous plasmacytosis", Dermatology, 190, pp.242~244 (1995)
- Kodama A, "Systemic and cutaneous plasmacytosis with multiple skin lesions and polyclonal hypergammaglobulinaemia: significant serum interleukin-6 levels", Br J Dermatol, 127, pp.49~53 (1992)
- Kayasut K, "Are multicentric Castleman’s disease with cutaneous plasmacytosis and systemic plasmacytosis the same entity", Histopathology, 49, pp.557~558 (2006)
- Shadel BN, "Cutaneous and systemic plasmacytosis in an Asian male born in the North American continent: a controversial entity potentially related to multicentric Castleman disease", J Cutan Pathol, 37, pp.697~702 (2010)
- Higashi Y, "Multicentric Castleman disease with cutaneous manifestations: report of 2 cases and comparison with systemic plasmacytosis", Dermatology, 214, pp.170~173 (2007)
- Rosmaninho A, "Red nose: primary cutaneous marginal zone B-cell lymphoma", Leuk Res, 34, pp.682~684 (2010)
- Kumar TS, "Approach to a patient with connective tissue disease", Indian J Pediatr, 77, pp.1157~1164 (2010)
- Gan EY, "Primary cutaneous nodular amyloidosis initially presenting with eczema", Singapore Med J, 51, pp.e158~e160 (2010)