Invasive Cribriform Carcinoma Arising in Malignant Phyllodes Tumor of Breast: A Case Report
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Phyllodes tumor is an uncommon fibroepithelial neoplasm of the breast. And it is characterized by expanded stroma with increased cellularity and elongated epithelium-lined clefts. Mammary carcinomas within phyllodes tumors have been rarely reported. To date, however, no reports have described the invasive cribriform carcinoma arising in malignant phyllodes tumor. Here, we report a 62-year-old woman who presented with a large breast mass. Microscopically, the mass was a typical malignant phyllodes tumor showing well developed leaf-like architecture and stromal overgrowth with high cellularity and nuclear pleomorphism. In a portion of the tumor, however, the epithelial component showed a cribriform pattern of proliferation in the absence of myoepithelial cells, suggestive of the invasive cribriform carcinoma. To our knowledge, this is rare and it is difficult to make a differential diagnosis of it. Here, we report our case with a review of literatures.
Abstract
Phyllodes tumor is an uncommon fibroepithelial neoplasm of the breast. And it is characterized by expanded stroma with increased cellularity and elongated epithelium-lined clefts. Mammary carcinomas within phyllodes tumors have been rarely reported. To date, however, no reports have described the invasive cribriform carcinoma arising in malignant phyllodes tumor. Here, we report a 62-year-old woman who presented with a large breast mass. Microscopically, the mass was a typical malignant phyllodes tumor showing well developed leaf-like architecture and stromal overgrowth with high cellularity and nuclear pleomorphism. In a portion of the tumor, however, the epithelial component showed a cribriform pattern of proliferation in the absence of myoepithelial cells, suggestive of the invasive cribriform carcinoma. To our knowledge, this is rare and it is difficult to make a differential diagnosis of it. Here, we report our case with a review of literatures.
참고문헌 (20)
- Lee AH, "Recent developments in the histological diagnosis of spindle cell carcinoma, fibromatosis and phyllodes tumour of the breast", Histopathology, 52, pp.45~57 (2008)
- Tse GM, "Phyllodes tumor of the breast: an update", Breast Cancer, 17, pp.29~34 (2010)
- Abdul Aziz M, "Malignant phyllodes tumour with liposarcomatous differentiation, invasive tubular carcinoma, and ductal and lobular carcinoma in situ: case report and review of the literature", Patholog Res Int, 2010, pp.501274~ (2010)
- Korula A, "Malignant phyllodes tumour with intraductal and invasive carcinoma and lymph node metastasis", Singapore Med J, 49, pp.318~321 (2008)
- Sugie T, "A case of ductal carcinoma with squamous differentiation in malignant phyllodes tumor", Breast Cancer, 14, pp.327~332 (2007)
- Nomura M, "A case of noninvasive ductal carcinoma arising in malignant phyllodes tumor", Breast Cancer, 13, pp.89~94 (2006)
- Lim SM, "Ductal carcinoma in situ within phyllodes tumour: a rare occurrence", Pathology, 37, pp.393~396 (2005)
- Padmanabhan V, "Phyllodes tumor with lobular carcinoma in situ and liposarcomatous stroma", Pathology, 29, pp.224~226 (1997)
- Tavassoli FA, "World Health Organization classification of tumours: pathology and genetics of tumours of the breast and female genital organs", pp.99~103 (2003), IARC Press
- Parker SJ, "Phyllodes tumours", Postgrad Med J, 77, pp.428~435 (2001)
- Kodama T, "Invasive lobular carcinoma arising in phyllodes tumor of the breast", Virchows Arch, 442, pp.614~616 (2003)
- Yamaguchi R, "Ductal carcinoma in situ arising in a benign phyllodes tumor: report of a case", Surg Today, 38, pp.42~45 (2008)
- Ramdass MJ, "Phyllodes breast tumour showing invasive squamous-cell carcinoma with invasive ductal, clear-cell, secretory, and squamous components", Lancet Oncol, 7, pp.880~ (2006)
- Parfitt JR, "In-situ and invasive carcinoma within a phyllodes tumor associated with lymph node metastases", World J Surg Oncol, 2, pp.46~ (2004)
- Yasumura T, "Infiltrating ductal carcinoma developing within cystosarcoma phyllodes: a case report", Jpn J Surg, 18, pp.326~329 (1988)
- Knudsen PJ, "Cystosarcoma phylloides with lobular and ductal carcinoma in situ", Arch Pathol Lab Med, 111, pp.873~875 (1987)
- Sharma R, "Primary squamous cell carcinoma of breast in background of phyllodes tumor: a case report", Conn Med, 73, pp.341~343 (2009)
- Page DL, "Invasive cribriform carcinoma of the breast", Histopathology, 7, pp.525~536 (1983)
- Law YM, "Adenoid cystic carcinoma of the breast", Singapore Med J, 50, pp.8~11 (2009)
- Vieni S, "Secretory breast carcinoma with metastatic sentinel lymph node", World J Surg Oncol, 4, pp.88~ (2006)