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Gastric Adenocarcinoma of Fundic Gland Type: Report of Three Cases

김경미|김영은|박철근|박은수|Takashi Yao|Ryoji Kushima
대한병리학회|2012.06|Journal of Pathology and Translational Medicine|제46권 제3호|pp. 287-291|DOI http://dx.doi.org/10.4132/KoreanJPathol.2012.46.3.287

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참고문헌

키워드

Cell differentiationStomach neoplasmsFundic glandChief cellsgastricPepsinogen A
주제분류병리학

초록

Recently, fundic gland type gastric adenocarcinoma (GA-FG) has been reported as a new entity. This report describes GA-FG among Koreans for the first time. From March 2008 to July 2010 we identified only three cases of GA-FG out of over 6,000 GAs resected by endoscopy or surgery. Cell differentiation by mucin proteins, pepsinogen-I, and H+/K+-ATPase was evaluated. All three cases were male patients and diagnosed as early stage GA. Histologically, GA-FGs were well-differentiated adenocarcinoma with pale gray-blue, basophilic columnar or cuboidal cells and mildly enlarged nuclei, resembling chief cells. All three cases were positive for pepsinogen-I and were classified as gastric mucin phenotype. Among three histologic subtypes of GA-FG, since tumors were mainly composed of chief cells, our three cases were classified as chief cell predominant type. In conclusion, GA-FG is very rare among Koreans and pepsinogen-I and MUC6 expression are typical immunohistochemical findings in GA-FG suggesting differentiation toward fundic glands.

참고문헌 (16)

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