Current Concepts and Occurrence of Epithelial Odontogenic Tumors: I. Ameloblastoma and Adenomatoid Odontogenic Tumor
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Ameloblastomas and adenomatoid odontogenic tumors (AOTs) are common epithelial tumors of odontogenic origin. Ameloblastomas are clinico-pathologically classified into solid/multicystic, unicystic, desmoplastic, and peripheral types, and also divided into follicular, plexiform, acanthomatous, granular types, etc., based on their histological features. Craniopharyngiomas, derived from the remnants of Rathke’s pouch or a misplaced enamel organ, are also comparable to the odontogenic tumors. The malignant transformation of ameloblastomas results in the formation of ameloblastic carcinomas and malignant ameloblastomas depending on cytological dysplasia and metastasis, respectively. AOTs are classified into follicular, extrafollicular, and peripheral types. Ameloblastomas are common, have an aggressive behavior and recurrent course, and are rarely metastatic, while AOTs are hamartomatous benign lesions derived from the complex system of the dental lamina or its remnants. With advances in the elucidation of molecular signaling mechanisms in cells, the cytodifferentiation of epithelial tumor cells in ameloblastomas and AOTs can be identified using different biomarkers. Therefore, it is suggested that comprehensive pathological observation including molecular genetic information can provide a more reliable differential diagnosis for the propagation and prognosis of ameloblastomas and AOTs. This study aimed to review the current concepts of ameloblastomas and AOTs and to discuss their clinico-pathological features relevant to tumorigenesis and prognosis.
Abstract
Ameloblastomas and adenomatoid odontogenic tumors (AOTs) are common epithelial tumors of odontogenic origin. Ameloblastomas are clinico-pathologically classified into solid/multicystic, unicystic, desmoplastic, and peripheral types, and also divided into follicular, plexiform, acanthomatous, granular types, etc., based on their histological features. Craniopharyngiomas, derived from the remnants of Rathke’s pouch or a misplaced enamel organ, are also comparable to the odontogenic tumors. The malignant transformation of ameloblastomas results in the formation of ameloblastic carcinomas and malignant ameloblastomas depending on cytological dysplasia and metastasis, respectively. AOTs are classified into follicular, extrafollicular, and peripheral types. Ameloblastomas are common, have an aggressive behavior and recurrent course, and are rarely metastatic, while AOTs are hamartomatous benign lesions derived from the complex system of the dental lamina or its remnants. With advances in the elucidation of molecular signaling mechanisms in cells, the cytodifferentiation of epithelial tumor cells in ameloblastomas and AOTs can be identified using different biomarkers. Therefore, it is suggested that comprehensive pathological observation including molecular genetic information can provide a more reliable differential diagnosis for the propagation and prognosis of ameloblastomas and AOTs. This study aimed to review the current concepts of ameloblastomas and AOTs and to discuss their clinico-pathological features relevant to tumorigenesis and prognosis.
참고문헌 (97)
- Sarkar L, "Wnt", Shh interactions regulate ectodermal boundary formation during mammalian tooth development, 2000, pp.97, 4520~4524
- Thesleff I, "Epithelial-mesenchymal signaling during tooth development", Connect Tissue Res, 32, pp.9~15 (1995)
- Kim JY, "Adamantinoma of tibia with predominant features of fibrous dysplasia: a case report", J Korean Med Sci, 11, pp.444~448 (1996)
- Kato N, "Ameloblastoma with basal cell carcinoma-like feature emerging as a nasal polyp", Pathol Int, 49, pp.747~751 (1999)
- Reichart PA, "Ameloblastoma: biological profile of 3677 cases", Eur J Cancer B Oral Oncol, 31B, pp.86~99 (1995)
- Siar CH, "Ameloblastoma of the jaws: a retrospective analysis of 340 cases in a Malaysian population", J Oral Maxillofac Surg, 70, pp.608~615 (2012)
- Dhanuthai K, "Ameloblastoma: a multicentric study", Oral Surg Oral Med Oral Pathol Oral Radiol, 113, pp.782~788 (2012)
- Hong J, "Long-term follow up on recurrence of 305 ameloblastoma cases", Int J Oral Maxillofac Surg, 36, pp.283~288 (2007)
- Doscher JC, "A large calcifying lesion of the maxilla in a child", J Am Dent Assoc, 142, pp.1026~1030 (2011)
- Lim J, "Oligonucleotide microarray analysis of ameloblastoma compared with dentigerous cyst", J Oral Pathol Med, 35, pp.278~285 (2006)
- Snead ML, "Human ameloblastoma tumors express the amelogenin gene", Oral Surg Oral Med Oral Pathol, 74, pp.64~72 (1992)
- Deutsch D, "Tuftelin mRNA is expressed in a human ameloblastoma tumor", Connect Tissue Res, 39, pp.177~184 (1998)
- Je G. Chi, "The Structure of the Rat Ameloblastin Gene and Its Expression in Amelogenesis", Molecules and Cells, 15(2), pp.216~225 (2003), 한국분자세포생물학회
- Lee SK, "Ameloblastin expression in rat incisors and human tooth germs", Int J Dev Biol, 40, pp.1141~1150 (1996)
- Saku T, "Immunohistochemical demonstration of enamel proteins in odontogenic tumors", J Oral Pathol Med, 21, pp.113~119 (1992)
- Crivelini MM, "Expression of odontogenic ameloblast-associated protein, amelotin, ameloblastin, and amelogenin in odontogenic tumors: immunohistochemical analysis and pathogenetic considerations", J Oral Pathol Med, 41, pp.272~280 (2012)
- Al-Otaibi O, "Syndecan-1 (CD 138) surface expression marks cell type and differentiation in ameloblastoma, keratocystic odontogenic tumor, and dentigerous cyst", J Oral Pathol Med, 42, pp.186~193 (2013)
- Mishra M, "Perlecan (basement membrane heparan sulfate proteoglycan) and its role in oral malignancies: an overview", Indian J Dent Res, 22, pp.823~826 (2011)
- Masloub SM, "CD10 and osteopontin expression in dentigerous cyst and ameloblastoma", Diagn Pathol, 6, pp.44~ (2011)
- de Medeiros AM, "Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors", Eur Arch Otorhinolaryngol, 267, pp.303~310 (2010)
- Farias LC, "Epigenetic regulation of matrix metalloproteinase expression in ameloblastoma", BMC Clin Pathol, 12, pp.11~ (2012)
- Qian Y, "The role of RANKL and MMP-9 in the bone resorption caused by ameloblastoma", J Oral Pathol Med, 39, pp.592~598 (2010)
- Tekkesin MS, "The role of RANK", RANKL, Head Neck Pathol, pp.2011, 5[DOI]
- Sengüven B, "Investigation of interleukin-1 alpha and interleukin-6 expression and interleukin-1 alpha gene polymorphism in keratocystic odontogenic tumors and ameloblastomas", Med Oral Patol Oral Cir Bucal, 16, pp.467~472 (2011)
- Kumar H, "Immunohistochemical expression of cyclin D1 in ameloblastomas and adenomatoid odontogenic tumors", J Oral Maxillofac Pathol, 15, pp.283~287 (2011)
- Scheper MA, "Expression of midkine in ameloblastomas and its correlation with clinicopathologic parameters", Oral Surg Oral Med Oral Pathol Oral Radiol, 114, pp.497~502 (2012)
- Abdel-Aziz A, "EGFR, CD10 and proliferation marker Ki67 expression in ameloblastoma: possible role in local recurrence", Diagn Pathol, 7, pp.14~ (2012)
- Sharifi-Sistani N, "Immunohistochemical comparison of the expression of p53 and MDM2 proteins in ameloblastomas and keratocystic odontogenic tumors", J Craniofac Surg, 22, pp.1652~1656 (2011)
- Li N, "Expression of phosphorylated mTOR and its regulatory protein is related to biological behaviors of ameloblastoma", Int J Clin Exp Pathol, 5, pp.660~667 (2012)
- Karathanasi V, "TGF-beta1, Smad-2", -3, Smad-1, -8, and Smad-4 signaling factors are expressed in ameloblastomas, adenomatoid odontogenic tumors, and calcifying cystic odontogenic tumors: an immunohistochemical study, pp.J Oral Pathol Med, 2013[DOI]
- Sukarawan W, "WNT5A expression in ameloblastoma and its roles in regulating enamel epithelium tumorigenic behaviors", Am J Pathol, 176, pp.461~471 (2010)
- Sathi GA, "Osteogenic genes related to the canonic WNT pathway are down-regulated in ameloblastoma", Oral Surg Oral Med Oral Pathol Oral Radiol, 114, pp.771~777 (2012)
- Ponti G, "Ameloblastoma: a neglected criterion for nevoid basal cell carcinoma (Gorlin) syndrome", Fam Cancer, 11, pp.411~418 (2012)
- Park HR, "Nevoid basal cell carcinoma syndrome: report of a case", Korean J Pathol, 29, pp.263~267 (1995)
- Song KY, "Pathological analysis of the basal cell carcinoma", Korean J Pathol, 28, pp.160~167 (1994)
- Alves Pereira KM, "Freitas Rde A, de Souza LB. Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 109, pp.425~431 (2010)
- Modolo F, "Immunohistochemical expression of Rho GTPases in ameloblastomas", J Oral Pathol Med, 41, pp.400~407 (2012)
- Kumamoto H, "Immunohistochemical analysis of apoptosis-related factors (Fas, Fas ligand, caspase-3 and single-stranded DNA) in ameloblastomas", J Oral Pathol Med, 30, pp.596~602 (2001)
- Rizzardi C, "Apoptosis-related factors (TRAIL, DR4, DR5, DcR1, DcR2, apoptotic cells) and proliferative activity in ameloblastomas", Anticancer Res, 29, pp.1137~1142 (2009)
- Shahidi S, "Follicular ameloblastoma presenting as a sinonasal tumor", Iran Red Crescent Med J, 14, pp.113~116 (2012)
- Castro-Silva II, "Difficulties in the diagnosis of plexiform ameloblastoma", Oral Maxillofac Surg, 16, pp.115~118 (2012)
- Bansal M, "Acanthomatous ameloblastoma of anterior maxilla", J Indian Soc Pedod Prev Dent, 28, pp.209~211 (2010)
- Ahuja A, "Acanthomatous ameloblastoma masquerading as a squamous cell carcinoma", Cytopathology (2012)
- Gupta S, "Granular cell ameloblastoma showing desmoplasia", Ann Saudi Med, 32, pp.537~540 (2012)
- Bansal A, "Metastasizing granular cell ameloblastoma", J Oral Maxillofac Pathol, 16, pp.122~124 (2012)
- Sharma VK, "Hemangiomatous ameloblastoma in maxilla: a report of a very rare case", Dent Res J (Isfahan), 9, pp.345~349 (2012)
- Ide F, "Basaloid squamous cell carcinoma versus basal cell ameloblastoma", Oral Oncol, 34, pp.154~155 (1998)
- Saxena K, "Adenoid ameloblastoma with dentinoid", J Oral Maxillofac Pathol, 16, pp.272~276 (2012)
- Tateyama H, "Different keratin profiles in craniopharyngioma subtypes and ameloblastomas", Pathol Res Pract, 197, pp.735~742 (2001)
- 김태정, "상아질성 유령세포종과 관련된 사기질모세포종 - 1예 보고 -", Journal of Pathology and Translational Medicine, 40(4), pp.297~302 (2006), 대한병리학회
- Chaudhary Z, "Unicystic ameloblastoma: a diagnostic dilemma", Natl J Maxillofac Surg, 2, pp.89~92 (2011)
- Gupta N, "Unicystic ameloblastoma of the mandible", J Oral Maxillofac Pathol, 15, pp.228~231 (2011)
- De Melo WM, "Large unicystic ameloblastoma of the mandible: management guided by biological behavior", J Craniofac Surg, 23, pp.499~502 (2012)
- Kim J, "Ameloblastoma arising in odontogenic cysts: report of 5 cases and its histologic characteristics", Korean J Pathol, 20, pp.435~441 (1986)
- Cervelli D, "Giant neglected desmoplastic ameloblastoma: reconstruction with free fibula flap", J Craniofac Surg, 23, pp.171~174 (2012)
- Effiom OA, "Desmoplastic ameloblastoma: analysis of 17 Nigerian cases", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 111, pp.27~31 (2011)
- Bologna-Molina R, "Comparison of the value of PCNA and Ki-67 as markers of cell proliferation in ameloblastic tumors", Med Oral Patol Oral Cir Bucal, 18, pp.174~179 (2013)
- Kato H, "Peripheral ameloblastoma of the lower molar gingiva: a case report and immunohistochemical study", Tokai J Exp Clin Med, 37, pp.30~34 (2012)
- Ide F, "Peripheral ameloblastoma in-situ: an evidential fact of surface epithelium origin", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 108, pp.763~767 (2009)
- Beena VT, "Peripheral ameloblastoma: a case report and review of literature", Case Rep Dent, 2012, pp.571509~ (2012)
- Paulus W, "Odontogenic classification of craniopharyngiomas: a clinicopathological study of 54 cases", Histopathology, 30, pp.172~176 (1997)
- Giangaspero F, "Suprasellar papillary squamous epithelioma (“papillary craniopharyngioma”)", Am J Surg Pathol, 8, pp.57~64 (1984)
- Sekine S, "Expression of enamel proteins and LEF1 in adamantinomatous craniopharyngioma: evidence for its odontogenic epithelial differentiation", Histopathology, 45, pp.573~579 (2004)
- Badger KV, "The relationship of adamantinomatous craniopharyngioma to ghost cell ameloblastoma of the jaws: a histopathologic and immunohistochemical study", J Oral Pathol Med, 26, pp.349~355 (1997)
- Zoicas F, "Craniopharyngioma in adults", Front Endocrinol (Lausanne), 3, pp.46~ (2012)
- Rodriguez FJ, "The spectrum of malignancy in craniopharyngioma", Am J Surg Pathol, 31, pp.1020~1028 (2007)
- Horváth A, "Mandibular ameloblastic carcinoma in a young patient", Rom J Morphol Embryol, 53, pp.179~183 (2012)
- Casaroto AR, "Ameloblastic carcinoma, primary type: case report, immunohistochemical analysis and literature review", Anticancer Res, 32, pp.1515~1525 (2012)
- Bedi RS, "Ameloblastic carcinoma of maxilla", Natl J Maxillofac Surg, 3, pp.70~74 (2012)
- Yoon HJ, "Ameloblastic carcinoma: an analysis of 6 cases with review of the literature", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 108, pp.904~913 (2009)
- Pundir S, "Ameloblastic carcinoma: secondary dedifferentiated carcinoma of the mandible: report of a rare entity with a brief review", J Oral Maxillofac Pathol, 15, pp.201~204 (2011)
- Fujita S, "Cytopathologic features of secondary peripheral ameloblastic carcinoma: a case report", Diagn Cytopathol, 39, pp.354~358 (2011)
- Kawauchi S, "Spindle-cell ameloblastic carcinoma: a case report with immunohistochemical, ultrastructural, and comparative genomic hybridization analyses", Oncol Rep, 10, pp.31~34 (2003)
- Khojasteh A, "Hypermethylation of p16 tumor-suppressor gene in ameloblastic carcinoma, ameloblastoma, and dental follicles", J Oral Maxillofac Surg, 71, pp.62~65 (2013)
- Slootweg PJ, "Malignant ameloblastoma or ameloblastic carcinoma", Oral Surg Oral Med Oral Pathol, 57, pp.168~176 (1984)
- Dissanayake RK, "Review of metastasizing (malignant) ameloblastoma (METAM): pattern of metastasis and treatment", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 111, pp.734~741 (2011)
- Lai H, "Benign metastasizing ameloblastoma or malignant ameloblastoma?", J Craniofac Surg, 22, pp.995~997 (2011)
- Baskaran P, "Adenomatoid odontogenic tumor: a report of two cases with histopathology correlation", J Clin Imaging Sci, 1, pp.64~ (2011)
- Vasudevan K, "Adenomatoid odontogenic tumor, an uncommon tumor", Contemp Clin Dent, 3, pp.245~247 (2012)
- Sharma N, "Adenomatoid odontogenic tumor: as an unusual mandibular manifestation", Contemp Clin Dent, 3(Suppl 1), pp.29~32 (2012)
- de Matos FR, "Adenomatoid odontogenic tumor: retrospective study of 15 cases with emphasis on histopathologic features", Head Neck Pathol, 6, pp.430~437 (2012)
- Chindasombatjaroen J, "Calcifying cystic odontogenic tumor and adenomatoid odontogenic tumor: radiographic evaluation", Oral Surg Oral Med Oral Pathol Oral Radiol, 114, pp.796~803 (2012)
- Becker T, "Critical evaluation of the radiological and clinical features of adenomatoid odontogenic tumour", Dentomaxillofac Radiol, 41, pp.533~540 (2012)
- Handschel JG, "Adenomatoid odontogenic tumor of the mandible: review of the literature and report of a rare case", Head Face Med, 1, pp.3~ (2005)
- Razavi SM, "A comparative immunohistochemical study of Ki-67 and Bcl-2 expression in solid ameloblastoma and adenomatoid odontogenic tumor", Dent Res J (Isfahan), 9, pp.192~197 (2012)
- Salehinejad J, "Immunohistochemical detection of p53 and PCNA in ameloblastoma and adenomatoid odontogenic tumor", J Oral Sci, 53, pp.213~217 (2011)
- Krishna A, "Overexpression of MDM2 protein in ameloblastomas as compared to adenomatoid odontogenic tumor", J Cancer Res Ther, 8, pp.232~237 (2012)
- Harnet JC, "Immunohistological features in adenomatoid odontogenic tumor: review of the literature and first expression and mutational analysis of beta-catenin in this unusual lesion of the jaws", J Oral Maxillofac Surg, 71, pp.706~713 (2013)
- Tsuneki M, "Podoplanin expression profiles characteristic of odontogenic tumor-specific tissue architectures", Pathol Res Pract, 208, pp.140~146 (2012)
- Poomsawat S, "Co-expression of hepatocyte growth factor and c-met in epithelial odontogenic tumors", Acta Histochem, 114, pp.400~405 (2012)
- Philipsen HP, "Variants of the adenomatoid odontogenic tumor with a note on tumor origin", J Oral Pathol Med, 21, pp.348~352 (1992)
- Philipsen HP, "Adenomatoid odontogenic tumor: biologic profile based on 499 cases", J Oral Pathol Med, 20, pp.149~158 (1991)
- Jivan V, "Adenomatoid odontogenic tumor (AOT) originating in a unicystic ameloblastoma: a case report", Head Neck Pathol, 1, pp.146~149 (2007)
- Prasad G, "Extrafollicular adenomatoid odontogenic tumour", BMJ Case Rep (2011)
- Avinash Tejasvi ML, "Atypical case of periapical adenomatoid odontogenic tumour", J Maxillofac Oral Surg, 9, pp.99~101 (2010)
- Ide F, "Rare peripheral odontogenic tumors: report of 5 cases and comprehensive review of the literature", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 106, pp.22~28 (2008)
- Sandhu SV, "Adenomatoid odontogenic tumor associated with dentigerous cyst of the maxillary antrum: a rare entity", J Oral Maxillofac Pathol, 14, pp.24~28 (2010)
