본문 바로가기
KERD
논문KCI 등재

White Matter Injury of Prematurity: Its Mechanisms and Clinical Features

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류병리학

초록

A developing central nervous system is vulnerable to various insults such as infection and ischemia. While increased understanding of the dynamic nature of brain development allows a deeper insight into the pathophysiology of perinatal brain injury, the precise nature of specific fetal and neonatal brain injuries and their short- and long-term clinical consequences need special attention and further elucidation. The current review will describe the pathophysiological aspects and clinical significance of white matter injury of prematurity, a main form of perinatal brain injury in premature newborns, with a particular emphasis on its potential antenatal components.

Abstract

A developing central nervous system is vulnerable to various insults such as infection and ischemia. While increased understanding of the dynamic nature of brain development allows a deeper insight into the pathophysiology of perinatal brain injury, the precise nature of specific fetal and neonatal brain injuries and their short- and long-term clinical consequences need special attention and further elucidation. The current review will describe the pathophysiological aspects and clinical significance of white matter injury of prematurity, a main form of perinatal brain injury in premature newborns, with a particular emphasis on its potential antenatal components.

참고문헌 (69)

  1. Nelson KB, "Neonatal signs as predictors of cerebral palsy", Pediatrics, 64, pp.225~232 (1979)
  2. Nelson KB, "Apgar scores as predictors of chronic neurologic disability", Pediatrics, 68, pp.36~44 (1981)
  3. Graham EM, "A systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathy", Am J Obstet Gynecol, 199, pp.587~595 (2008)
  4. Lai MC, "Perinatal hypoxic-ischemic encephalopathy", J Biomed Biotechnol, 2011, pp.609813~ (2011)
  5. Martinez-Biarge M, "Antepartum and intrapartum factors preceding neonatal hypoxic-ischemic encephalopathy", Pediatrics, 132, pp.e952~e959 (2013)
  6. Blumberg RM, "Relation between delayed impairment of cerebral energy metabolism and infarction following transient focal hypoxia-ischaemia in the developing brain", Exp Brain Res, 113, pp.130~137 (1997)
  7. Gilland E, "Temporal changes of regional glucose use, blood flow, and microtubule-associated protein 2 immunos-taining after hypoxia-ischemia in the immature rat brain", J Cereb Blood Flow Metab, 18, pp.222~228 (1998)
  8. Ferriero DM, "Neonatal brain injury", N Engl J Med, 351, pp.1985~1995 (2004)
  9. Gopagondanahalli KR, "Preterm hypoxic-ischemic encephalopathy", Front Pediatr, 4, pp.114~ (2016)
  10. Yokochi K, "Magnetic resonance imaging in children with neonatal asphyxia: correlation with developmental sequelae", Acta Paediatr, 85, pp.88~95 (1996)
  11. Murray AL, "White matter abnormalities and impaired attention abilities in children born very preterm", Neuroimage, 124, pp.75~84 (2016)
  12. Back SA, "Late oligodendrocyte progenitors coincide with the developmental window of vulnerability for human perinatal white matter injury", J Neurosci, 21, pp.1302~1312 (2001)
  13. Back SA, "Arrested oligodendrocyte lineage progression during human cerebral white matter development: dissociation between the timing of progenitor differentiation and myelinogenesis", J Neuropathol Exp Neurol, 61, pp.197~211 (2002)
  14. van Tilborg E, "Impaired oligodendrocyte maturation in preterm infants: potential therapeutic targets", Prog Neurobiol, 136, pp.28~49 (2016)
  15. Wellmann S, "Focal necrosis and disturbed myelination in the white matter of newborn infants: a tale of too much or too little oxygen", Front Pediatr, 2, pp.143~ (2014)
  16. Romero R, "The preterm parturition syndrome", BJOG, 113(Suppl 3), pp.17~42 (2006)
  17. Marlow N, "Neurologic and developmental disability at six years of age after extremely preterm birth", N Engl J Med, 352, pp.9~19 (2005)
  18. Folkerth RD, "Neuropathologic substrate of cerebral palsy", J Child Neurol, 20, pp.940~949 (2005)
  19. Bolisetty S, "Intraventricular hemorrhage and neurodevelopmental outcomes in extreme preterm infants", Pediatrics, 133, pp.55~62 (2014)
  20. Cooper MS, "Seizures in children with cerebral palsy and white matter injury", Pediatrics, 139, pp.e20162975~ (2017)
  21. Wagenaar N, "Clinical risk factors for punctate white matter lesions on early magnetic resonance imaging in preterm newborns", J Pediatr, 182, pp.34~40.e1 (2017)
  22. Herzog M, "Impact of risk factors other than prematurity on periventricular leukomalacia: a population-based matched case control study", Eur J Obstet Gynecol Reprod Biol, 187, pp.57~59 (2015)
  23. Gagliardi L, "Pregnancy disorders leading to very preterm birth influence neonatal outcomes: results of the population-based ACTION cohort study", Pediatr Res, 73, pp.794~801 (2013)
  24. Zupan V, "Periventricular leukomalacia: risk factors revisited", Dev Med Child Neurol, 38, pp.1061~1067 (1996)
  25. Bauer M, "Cystic periventricular leukomalacia in preterm infants: an analysis of obstetric risk factors", Early Hum Dev, 85, pp.163~169 (2009)
  26. Pooh RK, "Imaging diagnosis of congenital brain anomalies and injuries", Semin Fetal Neonatal Med, 17, pp.360~376 (2012)
  27. Rosier-van Dunné FM, "Changes in echogenicity in the fetal brain: a prevalence study in fetuses at risk for preterm delivery", Ultrasound Obstet Gynecol, 29, pp.644~650 (2007)
  28. Padilla-Gomes NF, "Prevalence of neonatal ultrasound brain lesions in premature infants with and without intrauterine growth restriction", Acta Paediatr, 96, pp.1582~1587 (2007)
  29. Larroque B, "White matter damage and intraventricular hemorrhage in very preterm infants: the EPIPAGE study", J Pediatr, 143, pp.477~483 (2003)
  30. Ancel PY, "Cerebral palsy among very preterm children in relation to gestational age and neonatal ultrasound abnormalities : the EPIPAGE cohort study", Pediatrics, 117, pp.828~835 (2006)
  31. Rosier-van Dunné FM, "Placental histology related to fetal brain sonography", Arch Dis Child Fetal Neonatal Ed, 96, pp.F53~F58 (2011)
  32. Anblagan D, "Association between preterm brain injury and exposure to chorioamnionitis during fetal life", Sci Rep, 6, pp.37932~ (2016)
  33. Banovic V, "Fetal brain magnetic resonance imaging and long-term neurodevelopmental impairment", Int J Gynaecol Obstet, 125, pp.237~240 (2014)
  34. Doneda C, "Prenatal MR imaging detection of deep medullary vein involvement in fetal brain damage", AJNR Am J Neuroradiol, 32, pp.E146~E149 (2011)
  35. Alderliesten T, "Cerebral oxygenation, extraction, and autoregulation in very preterm infants who develop peri-intraventricular hemorrhage", J Pediatr, 162, pp.698~704.e2 (2013)
  36. Wong FY, "Impaired autoregulation in preterm infants identified by using spatially resolved spectroscopy", Pediatrics, 121, pp.e604~e611 (2008)
  37. Deng W, "Neurobiology of injury to the developing brain", Nat Rev Neurol, 6, pp.328~336 (2010)
  38. Khwaja O, "Pathogenesis of cerebral white matter injury of prematurity", Arch Dis Child Fetal Neonatal Ed, 93, pp.F153~F161 (2008)
  39. Volpe JJ, "Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances", Lancet Neurol, 8, pp.110~124 (2009)
  40. Rezaie P, "Periventricular leukomalacia, inflammation and white matter lesions within the developing nervous system", Neuropathology, 22, pp.106~132 (2002)
  41. Zhao J, "Effect of intrauterine infection on brain development and injury", Int J Dev Neurosci, 31, pp.543~549 (2013)
  42. Back SA, "Pathophysiology of glia in perinatal white matter injury", Glia, 62, pp.1790~1815 (2014)
  43. Burd I, "Excitotoxicity as a common mechanism for fetal neuronal injury with hypoxia and intrauterine inflammation", Adv Pharmacol, 76, pp.85~101 (2016)
  44. Perrone S, "Brain susceptibility to oxidative stress in the perinatal period", J Matern Fetal Neonatal Med, 28(Suppl 1), pp.2291~2295 (2015)
  45. Back SA, "Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia", J Neurosci, 22, pp.455~463 (2002)
  46. Back SA, "Selective vulnerability of preterm white matter to oxidative damage defined by F2-isoprostanes", Ann Neurol, 58, pp.108~120 (2005)
  47. Boyle AK, "Preterm birth: Inflammation, fetal injury and treatment strategies", J Reprod Immunol, 119, pp.62~66 (2017)
  48. Malaeb S, "Fetal inflammatory response and brain injury in the preterm newborn", J Child Neurol, 24, pp.1119~1126 (2009)
  49. Yuan TM, "Intrauterine infection", inflammation and perinatal brain damage: role of glial cells and Toll-like receptor signaling, 2010, pp.229, 16~25
  50. Murthy V, "Antenatal infection", inflammation and fetal tissue injury, 2007, pp.21, 479~489
  51. Skullerud K, "Clinicopathological study of germinal matrix hemorrhage, pontosubicular necrosis, and periventricular leukomalacia in stillborn", Childs Nerv Syst, 4, pp.88~91 (1988)
  52. Nakamura Y, "Cystic brain lesion in utero", Acta Pathol Jpn, 36, pp.613~620 (1986)
  53. Chang KT, "Third-trimester stillbirths : correlative neuropathology and placental pathology", Pediatr Dev Pathol, 14, pp.345~352 (2011)
  54. Maleki Z, "Periventricular leukomalacia and placental histopathologic abnormalities", Obstet Gynecol, 114, pp.1115~1120 (2009)
  55. Oda N, "Obstetric risk factors associated with the development of periventricular leukomalacia in preterm infants born to mothers complicated by placenta previa", Fetal Diagn Ther, 24, pp.345~348 (2008)
  56. Wharton KN, "Severe umbilical cord inflammation-a predictor of periventricular leukomalacia in very low birth weight infants", Early Hum Dev, 77, pp.77~87 (2004)
  57. Kumazaki K, "Placental features in preterm infants with periventricular leukomalacia", Pediatrics, 109, pp.650~655 (2002)
  58. Drobyshevsky A, "Near-term fetal hypoxiaischemia in rabbits : MRI can predict muscle tone abnormalities and deep brain injury", Stroke, 43, pp.2757~2763 (2012)
  59. Drobyshevsky A, "Motor deficits are triggered by reperfusion-reoxygenation injury as diagnosed by MRI and by a mechanism involving oxidants", J Neurosci, 32, pp.5500~5509 (2012)
  60. Hagberg H, "Models of white matter injury: comparison of infectious, hypoxic-ischemic, and excitotoxic insults", Ment Retard Dev Disabil Res Rev, 8, pp.30~38 (2002)
  61. Derrick M, "A model of cerebral palsy from fetal hypoxia-ischemia", Stroke, 38(2 Suppl), pp.731~735 (2007)
  62. Buser JR, "Timing of appearance of late oligodendrocyte progenitors coincides with enhanced susceptibility of preterm rabbit cerebral white matter to hypoxia-ischemia", J Cereb Blood Flow Metab, 30, pp.1053~1065 (2010)
  63. Derrick M, "Preterm fetal hypoxia-ischemia causes hypertonia and motor deficits in the neonatal rabbit: a model for human cerebral palsy", J Neurosci, 24, pp.24~34 (2004)
  64. Burd I, "Models of fetal brain injury, intrauterine inflammation, and preterm birth", Am J Reprod Immunol, 67, pp.287~294 (2012)
  65. Duncan JR, "White matter injury after repeated endotoxin exposure in the preterm ovine fetus", Pediatr Res, 52, pp.941~949 (2002)
  66. Girard S, "Role of perinatal inflammation in cerebral palsy", Pediatr Neurol, 40, pp.168~174 (2009)
  67. Field NT, "Perinatal effects of Gardnerella vaginalis deciduitis in the rabbit", Am J Obstet Gynecol, 168(3), pp.988~994 (1993)
  68. Yoon BH, "Experimentally induced intrauterine infection causes fetal brain white matter lesions in rabbits", Am J Obstet Gynecol, 177, pp.797~802 (1997)
  69. Saadani-Makki F, "Intrauterine endotoxin administration leads to white matter diffusivity changes in newborn rabbits", J Child Neurol, 24, pp.1179~1189 (2009)

관련 논문AI추천

이 간행물의 다른 논문 (9건)