Proto-oncogene Pokemon in thyroid cancer: a potential promoter of tumorigenesis in papillary thyroid carcinoma
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Pokemon is an oncogenic transcription regulator that plays a critical role in cellular differentiation. Although it has been found to be overexpressed in several types of cancer involving different organs, its role in thyroid gland has yet to be reported. The objective of this study was to evaluate the expression of Pokemon in papillary thyroid carcinoma (PTC) based on clinicopathological parameters.Methods: Tissue microarray samples derived from patients with PTC or benign thyroid disease were used to evaluate Pokemon expression based on immunohistochemical analysis. Correlations of its expression with various clinicopathological parameters were then analyzed.Results: Pokemon expression was observed in 22.0% of thyroid follicular cells from the normal group, 44.0% from the group with benign thyroid diseases, and 92.1% from the group with PTC (p < .001). The intensity of Pokemon expression was markedly higher in the PTC group. Pokemon expression level and PTC tumor size showed an inverse correlation. T1a tumors showed strong expression levels of Pokemon. However, larger tumors showed weak expression (p = .006).Conclusions: Pokemon expression is associated with tumorigenesis of PTC, with expression showing an inverse correlation with PTC tumor size. This might be related to the negative regulation of aerobic glycolysis by Pokemon.
Abstract
Background: Pokemon is an oncogenic transcription regulator that plays a critical role in cellular differentiation. Although it has been found to be overexpressed in several types of cancer involving different organs, its role in thyroid gland has yet to be reported. The objective of this study was to evaluate the expression of Pokemon in papillary thyroid carcinoma (PTC) based on clinicopathological parameters.Methods: Tissue microarray samples derived from patients with PTC or benign thyroid disease were used to evaluate Pokemon expression based on immunohistochemical analysis. Correlations of its expression with various clinicopathological parameters were then analyzed.Results: Pokemon expression was observed in 22.0% of thyroid follicular cells from the normal group, 44.0% from the group with benign thyroid diseases, and 92.1% from the group with PTC (p < .001). The intensity of Pokemon expression was markedly higher in the PTC group. Pokemon expression level and PTC tumor size showed an inverse correlation. T1a tumors showed strong expression levels of Pokemon. However, larger tumors showed weak expression (p = .006).Conclusions: Pokemon expression is associated with tumorigenesis of PTC, with expression showing an inverse correlation with PTC tumor size. This might be related to the negative regulation of aerobic glycolysis by Pokemon.
참고문헌 (25)
- Al-Brahim N, "Papillary thyroid carcinoma : an overview", Arch Pathol Lab Med, 130, pp.1057~1062 (2006)
- Ito Y, "Overall survival of papillary thyroid carcinoma patients : a singleinstitution long-term follow-up of 5897 patients", World J Surg, 42, pp.615~622 (2018)
- Soares P, "Prognostic biomarkers in thyroid cancer", Virchows Arch, 464, pp.333~346 (2014)
- Mercante G, "Prognostic factors affecting neck lymph node recurrence and distant metastasis in papillary microcarcinoma of the thyroid : results of a study in 445 patients", Thyroid, 19, pp.707~716 (2009)
- D’Cruz AK, "Molecular markers in welldifferentiated thyroid cancer", Eur Arch Otorhinolaryngol, 275, pp.1375~1384 (2018)
- Maeda T, "Role of the proto-oncogene Pokemon in cellular transformation and ARF repression", Nature, 433, pp.278~285 (2005)
- Mao A, "ZBTB7A promotes migration, invasion and metastasis of human breast cancer cells through NF-kappaB-induced epithelial-mesenchymal transition in vitro and in vivo", J Biochem, 166, pp.485~493 (2019)
- Jeon BN, "Proto-oncogene FBI-1(Pokemon", ZBTB7A)represses transcription of the tumor suppressor Rb gene via binding competition with Sp1 and recruitment of co-repressors, 2008, pp.283, 33199~33210
- Choi WI, "Proto-oncogene FBI-1 represses transcription of p21CIP1 by inhibition of transcription activation by p53 and Sp1", J Biol Chem, 284, pp.12633~12644 (2009)
- Zhang NN, "Homeostatic regulatory role of Pokemon in NF-kappaB signaling : stimulating both p65 and IkappaBalpha expression in human hepatocellular carcinoma cells", Mol Cell Biochem, 372, pp.57~64 (2013)
- Zu X, "Pro-oncogene Pokemon promotes breast cancer progression by upregulating survivin expression", Breast Cancer Res., 13, pp.R26~ (2011)
- Yang X, "Zbtb7 suppresses the expression of CDK2 and E2F4 in liver cancer cells : implications for the role of Zbtb7 in cell cycle regulation", Mol Med Rep, 5, pp.1475~1480 (2012)
- Lee DK, "POZ domain transcription factor, FBI-1, represses transcription of ADH5", FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1, 2002, pp.277, 26761~26768
- Choi WI, "Proto-oncogene FBI-1(Pokemon)and SREBP-1 synergistically activate transcription of fatty-acid synthase gene(FASN)", J Biol Chem, 283, pp.29341~29354 (2008)
- Aggarwal A, "Expression of leukemia", lymphoma-related factor(LRF, Exp Mol Pathol, pp.2010, 89[DOI]
- Aggarwal H, "Epidermal growth factor increases LRF", Pokemon expression in human prostate cancer cells, 2011, pp.91, 496~501
- Hong X, "Pokemon and MEF2D co-operationally promote invasion of hepatocellular carcinoma", Tumour Biol, 36, pp.9885~9893 (2015)
- Sartini D, "Pokemon proto-oncogene in oral cancer : potential role in the early phase of tumorigenesis", Oral Dis, 21, pp.462~469 (2015)
- Jiao W, "Expression of the Pokemon proto-oncogene in nasopharyngeal carcinoma cell lines and tissues", Asian Pac J Cancer Prev, 14, pp.6315~6319 (2013)
- Kong J, "Pokemon promotes the invasiveness of hepatocellular carcinoma by enhancing MEF2D transcription", Hepatol Int, 10, pp.493~500 (2016)
- Jiang L, "Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers", Mol Cancer, 9, pp.318~ (2010)
- Zhang QL, "Depletion of Pokemon gene inhibits hepatocellular carcinoma cell growth through inhibition of H-ras", Onkologie, 34, pp.526~531 (2011)
- Apostolopoulou K, "Gene amplification is a relatively frequent event leading to ZBTB7A(Pokemon)overexpression in non-small cell lung cancer", J Pathol, 213, pp.294~302 (2007)
- Vander Heiden MG, "Understanding the Warburg effect : the metabolic requirements of cell proliferation", Science, 324, pp.1029~1033 (2009)
- Liu XS, "ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis", Genes Dev, 28, pp.1917~1928 (2014)