간내선암종 감별을 위한 종양표지단백의 발현 양상
Expression Patterns of Tumor Related Proteins for Differential Diagnoses of Intrahepatic Adenocarcinomas
2
조회
0
다운로드
0
인용
0
참고문헌
초록
Abstract
Background : Differential diagnoses of intrahepatic adenocarcinomas (IHAC) play an important role in the detecting primary sites and the determining type of treatment and overall prognosis of the patient. However, histopathologic findings alone have limitations of differential diagnoses of IHAC. Methods : To clarify which tumor related proteins (TRP) are useful for differential diagnoses of IHAC, TRP expression were investigated immunohistochemically, using MUC5AC, MUC2, mAb 91.9H, MUC1, and pS2, and by high iron diamine (HID) staining in 61 clinically confirmed IHACs. Results : MUC5AC (9/18, p<0.05) and MUC1 (17/18, p>0.05) displayed the most frequent expression in cholangiocarcinomas, and MUC2 (11/18, p<0.05), mAb 91.9H (16/18, p<0.05), and HID (16/18, p<0.05) in colorectal adenocarcinomas. pS2 (3/11, p>0.05) was expressed more often in pancreatic adenocarcinomas than other IHAC, while MUC2 and 91.9H were not expressed at all in pancreatic adenocarcinomas. The positivity of several TRP did not correlate with tumor differentiation. Conclusions : MUC5AC, MUC2, mAb 91.9H, and HID may be useful in differentiating cholangiocarcinomas from colorectal adenocarcinomas.
참고문헌 (26)
- "Robbins Pathologic Basis of Disease", pp.888~91 (1999)
- "A prospective study of 22 707 men in Taiwan", 2, pp.1129~33, Lin CC
- "The catalogof human cytokeratins:patterns of expression in normal epithelia,tumors and cultured cells", 31, pp.11~24 (1982)
- "Cytokeratin 20 in humancarcinomas A new histodiagnostic marker detected by monoclonalantibodies", 140, pp.427~47
- "Expression of cytokeratins 7 and 20 in cholangiocarcinomaand metastatic colonic adenocarcinoma of the liver", 33, pp.42~7 (1999)
- "Occurrence and prognosticimplications of lymph node micrometastases in patients withdukes’ B colorectal carcinoma", 17, pp.141~7 (2001)
- "Biochemistry and pathological importanceof mucin-associated antigens in gastrointestinal neoplasia", 79, pp.201~48 (2000)
- "Developmental expression of mucin genes in thehuman gastrointestinal system", 42, pp.220~6 (1998)
- "Mucin glycoproteins in neoplasia", 13, pp.693~707 (1996)
- "Variation of human mucingene expression in gastric cancer cell lines and gastric mucous cellprimary clultures", 78, pp.832~41 (1999)
- "Developmental mucingene expression in the gastroduodenal tract and accessory digestiveglands A relationship to gastric carcinoma", mau(ury v), pp.1657~66
- "Diversity of Mucin genes", 109, pp.999~1001, and expression
- "An immunohistochemicalsurvey of pS2 expression in human epithelial cancers", 50, pp.302~4 (1992)
- "Prognostic significance ofcytosolic pS2 protein content in gastric cancer", 16, pp.37~44
- "pS2protein expression in gastric carcinoma", 32a, pp.1585~90 (1996)
- "pS2 protein in gastric carcinoma and normalgastric mucosa:association with clinicopathological parameters andpatient survival", 171, pp.263~9 (1993)
- "pS2 immunostaining of colorectal carcinoma", 6, pp.446~8
- "Association of the human spasmolyticpolypeptide and an estrogen-induced breast cancer protein(pS2)with human pancreatic carcinoma", 66, pp.187~92 (1992)
- "Immunolocalizationof pS2,a putative growth factor,in pancreatic carcinoma", 10, pp.396~400 (1995)
- "Immunohistochemistry of pS2 in normal human breast andin various histological forms of breast tumours", 23, pp.249~56 (1993)
- "Prevalence of Barrett’s esophagusand expression of mucin antigens detected by a panel of monoclonalantibodies in Barrett’s esophagus and esophageal adenocarcinomain Japan", 35, pp.583~92 (2000)
- "Expression of sulfatedcarbohydrate chains detected by monoclonal antibody 91", 85, pp.400~8 (1994)
- "Monoclonal antibody91", 8, pp.1237~42 (1998)
- "Novcarbohydrate specificity of monoclonal antibody 91 recognition of sulfo-Lewis", pp.374~81
- "Expression of sulfomucinsin normal mucosae,colorectal adenocarcinomas,and metastases", 86, pp.1060~7 (1995)
- "Detection of sulfated glycoproteinsin intestinal metaplasia:a comparison of traditional mucin stainingwith immunohistochemistry for the sulfo-Lewis(a)carbohydrateepitope", 56, pp.703~8 (2003)
