본문 바로가기
KERD
논문KCI 등재

신세포암종에서 이형 CD44 단백 발현의 의의

Expression of CD44 Isoforms and Its Significance in Renal Cell Carcinoma

홍희연|김태숙|윤길숙
대한병리학회|2005.08|Journal of Pathology and Translational Medicine|제39권 제4호|pp. 251-257

2

조회

0

다운로드

1

인용

0

참고문헌

주제분류병리학

초록

Abstract

Background : CD44 is a transmembranous glycoprotein that participates in cell-cell and cellmatrix interactions, and it also contributes to cell migration. In vitro studies have suggested that the expression of CD44 isoforms is associated with tumor metastasis. Since it is not clear whether the CD44 isoforms play a role in the tumorigenesis, differentiation, progression or metastasis of renal cell carcinomas (RCCs). Methods : We performed immunohistochemistry with primary antibodies for the standard CD44 (CD44s) and the CD44 variant exon 6 (CD44v6) on the archival paraffin-embedded tissue microarray (TMA) specimens from 51 RCC patients. Results : In the normal kidney, the expressions of both CD44s and CD44v6 were negligible. The CD44s expression was increased in accordance with the tumor size (p<0.01), but it was not related to the microvessel density (MVD). No CD44v6 expression was observed in all RCC cases. Univariate analysis indicated that stage, tumor size, lymph node metastasis and distant organ metastasis were the statistically significant prognostic factors for disease free survival (DFS) (p<0.01), and the multivariate analysis proved that stage (p<0.01) and tumor size (p< 0.05) were the independent prognostic factors for DFS. Conclusions : Our results suggest that CD44s, but not CD44v6, plays a role in tumor progression and it could be a potential prognostic factor for patients with RCCs.

참고문헌 (30)

  1. "Renal cell carcinoma", 14, pp.280~5 (2002)
  2. "Estimates of the worldwide incidence of 25 major cancers in 1990", 80, pp.827~41 (1999)
  3. "and the American Joint Committee on Cancer", pp.981~6
  4. "CD44 cell adhesion molecules", 52, pp.189~96 (1999)
  5. "CD44 variant isoforms are preferentially expressed in basal epithelial of non-malignant human fetal and adult tissues", 101, pp.79~89 (1994)
  6. "CD44 in cancer progression:adhesion,migration and growth regulation", 35, pp.211~31 (2004)
  7. "CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid,thereby stimulating cell motility and chemotaxis", 59, pp.219~26 (1999)
  8. "CD44 is an independent prognostic factor in conventional renal cell carcinomas", 161, pp.1984~7 (1999)
  9. "CD44s and CD44v6 expression in localized T1-T2 conventional renal cell carcinomas", 193, pp.345~9 (2001)
  10. "CD44v6 expression is related to progression in renal epithelial tumours", 33, pp.39~45 (1998)
  11. "Prognostic significance of morphologic parameters in renal cell carcinoma", 6, pp.655~63 (1982)
  12. "The current state of renal cell carcinoma grading and the American Joint Committee on Cancer", pp.977~80
  13. "TNM staging of renal cell carcinoma and the American Joint Committee on Cancer", 80, pp.992~3
  14. "Reassessment of the 1997 TNM classification system for renal cell carcinoma", 98, pp.2329~34 (2003)
  15. "Tissue microarrays for high-throughput molecular profiling of tumor specimens", 4, pp.844~7 (1998)
  16. "A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells", 65, pp.13~24 (1991)
  17. "Expression of CD44 isoforms in renal cell tumors", 148, pp.453~63 (1996)
  18. "Expression and prognostic value of CD44 isoforms in transitional cell carcinoma of renal pelvis and ureter", 161, pp.805~9 (1999)
  19. "Expression and modulation of CD44 variant isoforms in humans", 124, pp.71~82 (1994)
  20. "Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12", 24, pp.489~501 (2005)
  21. "Binding and degradation of hyaluronan by human breast cancer cell lines expressing different forms of CD44:correlation with invasive potential", 160, pp.275~86 (1994)
  22. "CD44:the hyaluronan receptor", 103, pp.293~8 (1992)
  23. "and the American Joint Committee on Cancer", pp.994~6, Cancer
  24. "Renal cell carcinoma", 61, pp.1639~51 (1988)
  25. "Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma", 27, pp.612~24 (2003)
  26. "Expression ofCD44 isoforms in human renal cell carcinomas", 428, pp.267~73
  27. "Prognostic value of the expression of Ki-67", pp.1087~93
  28. "Clinical significance of cell proliferation,microvessel density,and CD44 adhesion molecule expression in renal cell carcinoma", 32, pp.1209~15 (2001)
  29. "Mesenchymal stem cells can be differentiated into endothelial cells in vitro", 22, pp.377~84 (2004)
  30. "Actin microdomains on endothelial cells:association with CD44,ERM proteins,and signaling molecules during quiescence and wound healing", 121, pp.361~9 (2004), Histochem Cell Biol

관련 논문AI추천

신세포암종에서 Osteopontin 발현의 예후 인자로서 의의김태숙, 윤길숙, 이향란, 홍희연대한병리학회 · Journal of Pathology and Translational Medicine2006 · 제40권 제3호비소세포폐암종에서 CD44s, CD44v5 및 CD44v6 발현의 임상병리학적 의의김재균, 송진미, 이경민, 이창훈대한병리학회 · Journal of Pathology and Translational Medicine2004 · 제38권 제2호위암에서 CD44s와 CD44v6 발현과 임상병리학적 상관관계에 관한 연구이주호, 임정화, 전호종대한병리학회 · Journal of Pathology and Translational Medicine2003 · 제37권 제5호림프절 전이 양성 및 음성 유방암종의 CD44 변이형들의 발현 차이에 관한 비교 연구박인애, 이호창, 조수연대한병리학회 · Journal of Pathology and Translational Medicine2005 · 제39권 제3호신세포암종에서 cDNA Microarray를 이용한 유전자 발현에 관한 연구 - Decorin 발현의 임상병리학적 분석김지연, 박도윤, 서강석, 이진숙, 최경운대한병리학회 · Journal of Pathology and Translational Medicine2003 · 제37권 제4호비소세포 폐암종의 CD44s 와 Cycylooxygenase-2 발현김정연, 김현정, 박경미, 임성직대한병리학회 · Journal of Pathology and Translational Medicine2006 · 제40권 제1호

이 간행물의 다른 논문 (12건)

간세포암종에서 Thrombospondin-1 및 -2의 발현: 종양 혈관신생 및 p53 과발현과의 연관성박호성, 손현진, 문우성, 강명재, 정재신pp. 215-221곧창자 샘암종에서 p53, bcl-2, Ki-67 발현과 세포자멸사에 대한 연구: 수술 전 방사선화학 치료 반응과의 상관관계유진영, 진형민, 김준기, 이정용, 김수지, 강석진, 조현민, 전정수, 강창석, 김성환pp. 222-228간내선암종 감별을 위한 종양표지단백의 발현 양상윤길숙, 배한익, 서인수, 엄지현, 김태숙, 이영화, 김미성, 김선주pp. 229-235Loss of PTEN Expression in Breast Cancers장선희, 최혜영, 이시내, 문병인, 한운섭, 조민선, 서현숙, 성순희, 임석아, 구혜수pp. 236-241대장의 샘종 및 샘암종에서 Osteopontin, ZO-1 및 E-cadherin의 발현임성철, 서재홍, 이미자, 기근홍, 정유경, 전호종pp. 242-250
원문 보기