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논문KCI 등재

방사선요법으로 치료한 자궁목의 침윤성 편평세포암종에서 HIF-1α 단백 발현

Expression of Hypoxia Inducible Factor-1α in Invasive Squamous Cell Carcinoma of Uterine Cervix Treated byRadiotherapy

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참고문헌

주제분류병리학

초록

Abstract

Background : Hypoxia-inducible factor-1 (HIF-1 ) is an intrinsic marker of tumor hypoxia, and this is associated with reduced radiosensitivity. Furthermore, HIF-1 can increase a tumor''s aggressiveness by promoting neoangiogenesis, cell proliferation and survival, and invasion. Methods : The expression of HIF-1 was was investigated by performing immunohistochemistry on the cervical tissue specimens obtained from 57 patients who had received radiotherapy combined with or without chemotherapy for stages I-III cervical squamous cell carcinoma. The staining results were compared with anemia, the stage, the radiotherapy response and patient survival by univariate and multivariate analysis. Results : In 57 patients, the expression of HIF-1 was seen in the tissue specimens of 46 patients (81.7%). Among them, 25 (54.3%), 14 (30.4%), and 7 (15.2%) of the patients'' tissue specimens showed weak, moderate and strong expressions, respectively. Six patients had a partial response after radiotherapy. Twelve patients (21.1%) died of cervical cancer. The increased expression of HIF-1 was significantly associated (p<0.05) with the disease stage and anemia. There were significant positive correlations between the increased expression of HIF-1 and the poor response after radiotherapy and the patients'' survival. Conclusions : The present result suggests that the overexpression of HIF-1 in the uterine cervix could be used as a prognostic indicator for the patients treated with radiotherapy.

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관련 논문AI추천

자궁목의 병기 I과 II 편평세포암종에서 Hypoxia-inducible Factor-1α 단백의 발현 : p53 단백 및 VEGF 발현과의 관련성서강석, 서동수, 윤만수, 이창훈대한병리학회 · Journal of Pathology and Translational Medicine2003 · 제37권 제2호자궁목암종에서 Hypoxia Inducible Factor-1α의 발현과 Cyclin A1, Cyclin B1 발현 및 임상병리학적 인자들과의 연관성김영태, 김현기, 박종필, 조남훈, 조재호, 표주연대한병리학회 · Journal of Pathology and Translational Medicine2009 · 제43권 제1호자궁목의 편평상피내병터와 침윤편평세포암종에서 Stromelysin-3의 발현남종희, 박은정, 박창수, 최유덕대한병리학회 · Journal of Pathology and Translational Medicine2002 · 제36권 제6호자궁경부암 환자의 임상병리학적 분석 및예후에 관한 연구김승보, 박성재, 이선경, 임명철대한산부인과학회 · Obstetrics & Gynecology Science2005 · 제48권 제2호자궁경부암종에서 방사선치료의 반응성과 p53, bcl-2 및 bax 단백질 발현박찬용, 석원익, 이광범, 이규찬, 이의돈, 이종민, 이지성, 최준렬, 하승연대한산부인과학회 · Obstetrics & Gynecology Science2002 · 제45권 제10호고위험 자궁경부암의 수술 후 보조요법으로서 Paclitaxel과Carboplatin 동시 항암화학방사선요법의 효능과 안전성강순범, 김재원, 박노현, 송용상, 이효표, 조현일대한산부인과학회 · Obstetrics & Gynecology Science2004 · 제47권 제5호

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