복합혈관내피종 - 1예 보고 -
Composite Hemangioendothelioma- A Case Report -
1
조회
0
다운로드
1
인용
0
참고문헌
초록
Abstract
Composite hemangioendothelioma (CHE) is a recently described vascular tumor of low-grade malignancy. We report a case of CHE in an 18-year-old woman who presented with a 2-month history of an enlarging palpable mass in the left axilla. Grossly, the excised tumor was relatively circumscribed, nodular, firm, and soft. It measured 6.0×4.5×4.0 cm. The cut surface revealed a whitish gray solid area and a dark red to tan cystic area containing necrotic material. Histologically, the tumor demonstrated variably intermixed benign and malignant vascular components. The benign components showed features of an arteriovenous malformation, capillary hemangioma, spindle cell hemangioma and cavernous hemangioma. The malignant components were composed of areas resembling retiform hemangioendothelioma, epithelioid hemangioendothelioma, Kaposiform hemangioendothelioma, and angiosarcoma. The angiosarcoma component showed a mixed epithelioid and spindle shaped cell morphology with moderate differentiation. A nearly imperceptible transition between the benign and malignant components was noted.
참고문헌 (15)
- Nayler S, "Compositehemangioendothelioma:a complex,low-grade vascular lesion mimickingangiosarcoma", 24, pp.352~361 (2000)
- Reis-Filho JS, "Congenital composite hemangioendothelioma:case report and reappraisal of the hemangioendotheliomaspectrum", 29, pp.226~231 (2002)
- Biagioli M, "Composite cutaneoushemangioendothelioma:case report and review of the literature", 30, pp.385~387 (2005)
- Mandahl N, "Trisomy 5 and loss of the Y chromosomeas the sole cytogenetic anomalies in a cavernous hemangioma", angiosarcoma, 1990, pp.1, 315~316
- McRae RD, "Malignant transformationin a laryngeal hemangioma", 99, pp.562~5
- Tohme C, "Cavernous hemangioma of theliver associated with angiosarcoma:malignant transformation", 15, pp.83~6 (1991)
- Damiani S, "Primary angiosarcomaof the parotid gland arising from benign congenital hemangioma", 96, pp.66~69 (2003)
- Rossi S, "Angiosarcoma arising in hemangioma", vascularmalformation:report of four cases and review of the literature, 2002, pp.26, 1319~1329
- Amo Y, "Expression of vascularendothelial growth factor in a human hemangiosarcoma cellline(ISO-HAS)", 293, pp.296~301 (2001)
- Zietz C, "MDM-2 oncoprotein overexpression,p53 gene mutation,and VEGF up-regulation in angiosarcomas", 153, pp.1425~1433 (1998)
- Masuzawa M, "Establishment of a humanhemangiosarcoma cell line(ISO-HAS)", 81, pp.305~308 (1999)
- Chaudhuri B, "Angiosarcoma arising in aplexiform neurofibroma:a case report", 46, pp.605~10 (1980)
- Meis-Kindblom JM, "Angiosarcoma of soft tissue:astudy of 80 cases", 22, pp.683~697 (1998)
- Trapella G, "Metastatic carcinomato artero-venous haemangioma", 37, pp.35~8
- Yegappan S, "Angiotropic lymphoma:an immunophenotypically and clinically heterogeneous lymphoma", 14, pp.1147~1156 (2001)