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논문KCI 등재

급성 세포성 이식거부반응을 동반한 이식신의 면역 관련 단백의 발현 양상

Immunohistochemical Profile of Acute Cellular Rejectionin Renal Allograft

조영미|박수길|유은실|한덕종|변승운|박종하
대한병리학회|2007.02|Journal of Pathology and Translational Medicine|제41권 제1호|pp. 15-20

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참고문헌

주제분류병리학

초록

Abstract

Background : We wanted to find an adjunctive marker(s) in renal allograft biopsies for predicting acute cellular rejection (ACR), and so the expression patterns of immune-related molecules were compared between ACR, borderline ACR and non-ACR cases. Methods : The expression patterns of Fas ligand (FasL), HLA-DR, granzyme B, caspase-3, CD56, interferon stimulated growth factor-3 (ISGF-3), and CD53 were assessed via immunohistochemical study in 75 allograft biopsies from patients with ACR (n=19), borderline ACR (n=22), and non-ACR (n=34). Results : Compared to those of the non-ACR group, the ACR group revealed an elevated number of FasL positive interstitial inflammatory cells, HLA-DR positive tubular inflammatory cells, cytoplasmic caspase-3 positive tubular epithelial cells, granzyme B positive interstitial mononuclear inflammatory cells and CD53 positive interstitial inflammatory cells. The expression patterns of the borderline ACR group were similar to those of non-ACR group, except for the intensity of FasL in the tubular epithelial cells. Conclusions : Immunohistochemical investigations of the adjunctive markers FasL, HLA-DR, granzyme B, caspase-3 and CD56 can be useful for making the diagnosis of ACR.

참고문헌 (27)

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