Adenocarcinoma Arising from Heterotopic Gastric Mucosain Cervical Esophagus- A Case Report -
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Heterotopic gastric mucosa (HGM) of the upper esophagus, referred as ‘‘cervical inlet patch (CIP)’’, is a benign lesion that is present in 3.8-10% of the adult population. Adenocarcinomas arising from HGM of the upper esophagus are exceedingly rare. The authors report one additional case of histologically confirmed adenocarcinoma arising from a CIP. The patient had concomitant primary adenocarcinoma of the colon. The right hemicolectomy specimen and total esophagectomy specimen after preoperative chemoradiotherapy showed histologically different adenocarcinomas. The residual esophageal tumor was characterized by large mucin pools, fibrous septa, and floating tumor cells. HGM of both the fundic and antral types was seen on the surface and sides of the tumor. The independent origins of the two cancers were confirmed by immunohistochemical studies for cytokeratins 7 and 20. Without further treatment, the patient remained free of disease after 29 months of follow-up.
Abstract
Heterotopic gastric mucosa (HGM) of the upper esophagus, referred as ‘‘cervical inlet patch (CIP)’’, is a benign lesion that is present in 3.8-10% of the adult population. Adenocarcinomas arising from HGM of the upper esophagus are exceedingly rare. The authors report one additional case of histologically confirmed adenocarcinoma arising from a CIP. The patient had concomitant primary adenocarcinoma of the colon. The right hemicolectomy specimen and total esophagectomy specimen after preoperative chemoradiotherapy showed histologically different adenocarcinomas. The residual esophageal tumor was characterized by large mucin pools, fibrous septa, and floating tumor cells. HGM of both the fundic and antral types was seen on the surface and sides of the tumor. The independent origins of the two cancers were confirmed by immunohistochemical studies for cytokeratins 7 and 20. Without further treatment, the patient remained free of disease after 29 months of follow-up.
참고문헌 (18)
- Faintuch J, "Adenocarcinoma and other unusual variants of esophageal cancer", Semin Oncol, 11, pp.196~202 (1984)
- von Rahden BH, "Esophageal adenocarcinomas in heterotopic gastric mucosa: review and report of a case with complete response to neoadjuvant radiochemotherapy", Dig Surg, 22, pp.107~112 (2005)
- Lauwers GY, "Adenocarcinoma of the upper esophagus arising in cervical ectopic gastric mucosa: rare evidence of malignant potential of so-called ‘‘inlet patch’’", Dig Dis Sci, 43, pp.901~907 (1998)
- von Rahden BH, "Liebermann-Meffert D, Siewert JR. Heterotopic gastric mucosa of the esophagus: literature-review and proposal of a clinicopathologic classification", Am J Gastroenterol, 99, pp.543~551 (2004)
- Tang P, "Inlet patch: prevalence, histologic type, and association with esophagitis, Barrett esophagus and antritis", Arch Pathol Lab Med, 128, pp.444~447 (2004)
- Jabbari M, "The inlet patch: heterotopic gastric mucosa in the upper esophagus", Gastroenterology, 89, pp.352~356 (1985)
- Sperling RM, "Adenocarcinoma arising in an inlet patch of the esophagus", Am J Gastroenterol, 90, pp.150~152 (1995)
- Galan AR, "Acid secretion from an esophageal inlet patch demonstrated by ambulatory pH monitoring", Gastroenterology, 115, pp.1574~1576 (1998)
- Buse PE, "Cervical esophageal web associated with a patch of heterotopic gastric mucosa", Abdom Imaging, 18, pp.227~228 (1993)
- Nakajima H, "pH profile of esophagus in patients with inlet patch of heterotopic gastric mucosa after tetragastrin stimulation: an endoscopic approach", Dig Dis Sci, 38, pp.1915~1919 (1993)
- Noguchi T, "Primary adenocarcinoma of the cervical esophagus arising from heterotopic gastric mucosa", J Gastroenterol, 3, pp.704~709 (2001)
- Noguchi T, "Primary adenocarcinoma of the cervical esophagus arising from heterotopic gastric mucosa", J Gastroenterol, 3, pp.704~709 (2001)
- Lee JM, "A case of primary esophageal adenocarcinoma originated from ectopic gastric mucosa in the upper esophagus", Korean J Gastroenterol, 4, pp.224~228 (2003)
- Chirieac LR, "Signet-ring cell or mucinous histology after preoperative chemoradiation and survival in patients with esophageal or esophagogastric junction adenocarcinoma", Clin Cancer Res, 11, pp.2229~2236 (2005)
- Cho KJ, "Pathologic observations in locally advanced gastric carcinomas after preoperative chemotherapy", J Korean Cancer Assoc, 24, pp.541~548 (1992)
- Ormsby AH, "The utility of cytokeratin subsets in distinguishing Barrett’s-related oesophageal adenocarcinoma from gastric adenocarcinoma", Histopathology, 38, pp.307~311 (2001)
- Lauwers GY, "Cytokeratins 7 and 20 and mucin core protein expression in esophageal cervical inlet patch", Am J Surg Pathol, 29, pp.437~442 (2005)
- Wang NP, "Coordinate expression of cytokeratins 7 and 20 defines unique subsets of carcinomas", Appl Immunohistochem Mol Morphol, 5, pp.216~222 (1997)