Langerhans Cell Sarcoma Arising in a Lymph Node - A Case Report and Review of the Literature -
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
We report a case of Langerhans cell sarcoma presented as a solitary mass in the left supraclavicular area in a 31-year-old woman. Computed tomography revealed a relatively well-defined and lightly enhancing mass in the left supraclavicular area, measuring 5.5×4.5×3.2 cm. Excision was subsequently performed. Microscopically, the specimen consisted of an enlarged and partially effaced lymph node. Nests of different size composed of atypical tumor cells were located in the paracortex and the medulla of the lymph node. The tumor cells exhibited abundant eosinophilic or clear cytoplasm and displayed marked nuclear atypia and increased mitotic figures. Infiltration of many eosinophils was identified in the periphery and between the tumor cells. The tumor cells were reactive for CD1a and S100 protein. Ultrastructually, they were found to have Birbeck granules in the cytoplasm.
Abstract
We report a case of Langerhans cell sarcoma presented as a solitary mass in the left supraclavicular area in a 31-year-old woman. Computed tomography revealed a relatively well-defined and lightly enhancing mass in the left supraclavicular area, measuring 5.5×4.5×3.2 cm. Excision was subsequently performed. Microscopically, the specimen consisted of an enlarged and partially effaced lymph node. Nests of different size composed of atypical tumor cells were located in the paracortex and the medulla of the lymph node. The tumor cells exhibited abundant eosinophilic or clear cytoplasm and displayed marked nuclear atypia and increased mitotic figures. Infiltration of many eosinophils was identified in the periphery and between the tumor cells. The tumor cells were reactive for CD1a and S100 protein. Ultrastructually, they were found to have Birbeck granules in the cytoplasm.
참고문헌 (19)
- Jaffe R, "Tumours derived from Langerhans cells, in WHO classification of tumours of haematopoietic and lymphoid tissues", pp.358~360 (2008), IARC Press
- Pileri SA, "Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases", Histopathology, 41, pp.1~29 (2002)
- Kawase T, "CD56", NCAM-positive Langerhans cell sarcoma: a clinicopathologic study of 4 cases, 2005, pp.81, 323~329
- Itoh H, "Primary cutaneous Langerhans cell histiocytosis showing malignant phenotype in an elderly woman: report of a fatal case", J Cutan Pathol, 28, pp.371~378 (2001)
- Tani M, "Malignant Langerhans cell tumour", Br J Dermatol, 126, pp.398~403 (1992)
- Misery L, "Malignant Langerhans cell tumor: a case with a favorable outcome associated with the absence of blood dendritic cell proliferation", J Am Acad Dermatol, 49, pp.527~529 (2003)
- Ferringer T, "Langerhans cell sarcoma", Am J Dermatopathol, 28, pp.36~39 (2006)
- Jülg BD, "Pulmonary manifestation of a Langerhans cell sarcoma: case report and review of the literature", Virchows Arch, 448, pp.369~374 (2006)
- Jong Sil Lee, "Langerhans Cell Sarcoma Arising from Langerhans Cell Histiocytosis: A Case Report", Journal of Korean Medical Science, 21(3), pp.577~580 (2006), 대한의학회
- Bohn OL, "Cutaneous Langerhans cell sarcoma: a case report and review of the literature", Int J Hematol, 85, pp.116~120 (2007)
- López-Ferrer P, "Fine needle aspiration cytology of Langerhans cell sarcoma", Cytopathology, 19, pp.59~61 (2008)
- Sumida K, "Leukemic transformation of Langerhans cell sarcoma", Int J Hematol, 87, pp.527~531 (2008)
- Deng A, "Primary cutaneous Langerhans cell sarcoma without Birbeck granules: indeterminate cell sarcoma", J Cutan Pathol, 35, pp.849~854 (2008)
- Diaz-Sarrio C, "Langerhans cell sarcoma in a patient who underwent transplantation", J Eur Acad Dermatol Venereol, 21, pp.973~976 (2007)
- Zhao G, "Langerhans cell sarcoma involving gallbladder and peritoneal lymph nodes: a case report", Int J Surg Pathol, 17, pp.347~353 (2009)
- Uchida K, "Langerhans cell sarcoma emanating from the upper arm skin: successful treatment by MAID regimen", J Orthop Sci, 13, pp.89~93 (2008)
- Ben-Ezra J, "Malignant histiocytosis X: a distinct clinicopathologic entity", Cancer, 68, pp.1050~1060 (1991)
- Howarth DM, "Langerhans cell histiocytosis: diagnosis, natural history, management, and outcome", Cancer, 85, pp.2278~2290 (1999)
- Newton WA Jr, "Histiocytosis: a histologic classification with clinical correlation", Perspect Pediatr Pathol, 1, pp.251~283 (1973)