Expression of MUC1 and MUC4 in Gallbladder Adenocarcinoma
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Recent reports have indicated that overexpression of mucin (MUC) 1 and/or MUC4 correlates with the occurrence and progression of extra-hepatobiliary malignancy. In this study, we investigated the expression of MUC1 and MUC4 and their prognostic significance in gallbladder adenocarcinoma. Methods: We examined 54 surgical gallbladder adenocarcinoma samples by immunohistochemistry for MUC1 and MUC4 expression. Staining was evaluated as a sum score of extent and intensity, dividing the samples into low and high expression groups. Results: The low expression group for both MUC1 and MUC4 was 10 samples (18.5%), and the high expression group was 44 samples (81.5%). High MUC1 expression was significantly correlated with more differentiated tumors (p=0.033), whereas high expression of MUC4 correlated with negative nodal status (p=0.012). Other pathological features were not correlated with MUC expression. Multivariate cox regression analysis showed that neither MUC1 nor MUC4 expression correlated with survival. Conclusions: Although there were some correlations found, a prognostic role for either MUC1 or MUC4 expression in gallbladder carcinoma was not identified in this study. Further investigation is required.
Abstract
Background: Recent reports have indicated that overexpression of mucin (MUC) 1 and/or MUC4 correlates with the occurrence and progression of extra-hepatobiliary malignancy. In this study, we investigated the expression of MUC1 and MUC4 and their prognostic significance in gallbladder adenocarcinoma. Methods: We examined 54 surgical gallbladder adenocarcinoma samples by immunohistochemistry for MUC1 and MUC4 expression. Staining was evaluated as a sum score of extent and intensity, dividing the samples into low and high expression groups. Results: The low expression group for both MUC1 and MUC4 was 10 samples (18.5%), and the high expression group was 44 samples (81.5%). High MUC1 expression was significantly correlated with more differentiated tumors (p=0.033), whereas high expression of MUC4 correlated with negative nodal status (p=0.012). Other pathological features were not correlated with MUC expression. Multivariate cox regression analysis showed that neither MUC1 nor MUC4 expression correlated with survival. Conclusions: Although there were some correlations found, a prognostic role for either MUC1 or MUC4 expression in gallbladder carcinoma was not identified in this study. Further investigation is required.
참고문헌 (30)
- Misra S, "Carcinoma of the gallbladder", Lancet Oncol, 4, pp.167~176 (2003)
- Kimura K, "Association of gallbladder carcinoma and anomalous pancreaticobiliary ductal union", Gastroenterology, 89, pp.1258~1265 (1985)
- Hanada K, "Gene mutations of K-ras in gallbladder mucosae and gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct", Am J Gastroenterol, 94, pp.1638~1642 (1999)
- Yonezawa S, "Expression profiles of MUC1, MUC2, and MUC4 mucins in human neoplasms and their relationship with biological behavior", Proteomics, 8, pp.3329~3341 (2008)
- Higashi M, "Expression of MUC1 and MUC2 mucin antigens in intrahepatic bile duct tumors: its relationship with a new morphological classification of cholangiocarcinoma", Hepatology, 30, pp.1347~1355 (1999)
- Tamada S, "Expression of MUC1 and MUC2 mucins in extrahepatic bile duct carcinomas: its relationship with tumor progression and prognosis", Pathol Int, 52, pp.713~723 (2002)
- Saitou M, "MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas", J Clin Pathol, 58, pp.845~852 (2005)
- Tamada S, "MUC4 is a novel prognostic factor of extrahepatic bile duct carcinoma", Clin Cancer Res, 12(14 Pt 1), pp.4257~4264 (2006)
- 권건영, "Expression of MUC1 and MUC4 and Its Prognostic Significance in Non-Small Cell Lung Carcinoma", The Korean Journal of Pathology, 44(4), pp.397~403 (2010), 대한병리학회
- Singh AP, "Aberrant expression of transmembrane mucins, MUC1 and MUC4, in human prostate carcinomas", Prostate, 66, pp.421~429 (2006)
- Jonckheere N, "The membrane-bound mucins: from cell signalling to transcriptional regulation and expression in epithelial cancers", Biochimie, 92, pp.1~11 (2010)
- Kawamoto T, "Expression of MUC1 recognized by a monoclonal antibody MY.1E12 is a useful biomarker for tumor aggressiveness of carcinoma of the gallbladder", Clin Exp Metastasis, 21, pp.353~362 (2004)
- Yamato T, "Expression of MUC1 and MUC2 mucin core proteins and their messenger RNA in gall bladder carcinoma: an immunohistochemical and in situ hybridization study", J Pathol, 188, pp.30~37 (1999)
- Ghosh M, "MUC 1 core protein as a marker of gallbladder malignancy", Eur J Surg Oncol, 31, pp.891~896 (2005)
- Yonezawa S, "Mucins in human neoplasms: clinical pathology, gene expression and diagnostic application", Pathol Int, 61, pp.697~716 (2011)
- Miyahara N, "MUC4 interacts with ErbB2 in human gallbladder carcinoma: potential pathobiological implications", Eur J Cancer, 44, pp.1048~1056 (2008)
- Shibahara H, "MUC4 is a novel prognostic factor of intrahepatic cholangiocarcinoma-mass forming type", Hepatology, 39, pp.220~229 (2004)
- Workman HC, "The membrane mucin Muc4 inhibits apoptosis induced by multiple insults via ErbB2-dependent and ErbB2-independent mechanisms", Cancer Res, 69, pp.2845~2852 (2009)
- Albrecht H, "MUC1 and MUC4: switching the emphasis from large to small", Cancer Biother Radiopharm, 26, pp.261~271 (2011)
- Hollingsworth MA, "Mucins in cancer: protection and control of the cell surface", Nat Rev Cancer, 4, pp.45~60 (2004)
- Hilkens J, "Cell membrane-associated mucins and their adhesion-modulating property", Trends Biochem Sci, 17, pp.359~363 (1992)
- Wang RQ, "Alterations of MUC1 and MUC3 expression in gastric carcinoma: relevance to patient clinicopathological features", J Clin Pathol, 56, pp.378~384 (2003)
- Hattrup CL, "MUC1 alters oncogenic events and transcription in human breast cancer cells", Breast Cancer Res, 8, pp.37~ (2006)
- Takao S, "Mucin core protein expression in extrahepatic bile duct carcinoma is associated with metastases to the liver and poor prognosis", Cancer, 86, pp.1966~1975 (1999)
- Chauhan SC, "Aberrant expression of MUC4 in ovarian carcinoma: diagnostic significance alone and in combination with MUC1 and MUC16 (CA125)", Mod Pathol, 19, pp.1386~1394 (2006)
- Weed DT, "MUC4 and ERBB2 expression in major and minor salivary gland mucoepidermoid carcinoma", Head Neck, 26, pp.353~364 (2004)
- Weed DT, "MUC4 and ErbB2 expression in squamous cell carcinoma of the upper aerodigestive tract: correlation with clinical outcomes", Laryngoscope, 114(8 Pt 2 Suppl 101), pp.1~32 (2004)
- Andrianifahanana M, "Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance", Clin Cancer Res, 7, pp.4033~4040 (2001)
- Xiong L, "Expressive levels of MUC1 and MUC5AC and their clinicopathologic significances in the benign and malignant lesions of gallbladder", J Surg Oncol, 105, pp.97~103 (2012)
- Vandenhaute B, "Mucin gene expression in biliary epithelial cells", J Hepatol, 27, pp.1057~1066 (1997)