Congenital Peribronchial Myofibroblastic Tumor: A Case Study and Literature Review
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Congenital peribronchial myofibroblastic tumor (CPMT) is a benign pulmonary spindle cell neoplasm of intrauterine and perinatal period, which is thought to arise from primitive peribronchial mesenchyme. We present a case detected incidentally in a one-month-old infant. The solid and partially necrotic tumor involved the right middle and lower lobes of the lung with extension to the diaphragm. Histologically, the tumor was composed of fasciculated monotonous spindle cells, proliferating peribronchiolar cartilage and round cells with rich vasculature, and high mitotic activity was identified in the round cell area. Immunohistochemical and electron microscopic studies showed that the spindle cells were myofibroblastic in phenotype. Although the tumor showed several malignant pathological features, recurrence was not observed in the two-year follow-up period, consistent with the benign clinical behavior of CPMT.
Abstract
Congenital peribronchial myofibroblastic tumor (CPMT) is a benign pulmonary spindle cell neoplasm of intrauterine and perinatal period, which is thought to arise from primitive peribronchial mesenchyme. We present a case detected incidentally in a one-month-old infant. The solid and partially necrotic tumor involved the right middle and lower lobes of the lung with extension to the diaphragm. Histologically, the tumor was composed of fasciculated monotonous spindle cells, proliferating peribronchiolar cartilage and round cells with rich vasculature, and high mitotic activity was identified in the round cell area. Immunohistochemical and electron microscopic studies showed that the spindle cells were myofibroblastic in phenotype. Although the tumor showed several malignant pathological features, recurrence was not observed in the two-year follow-up period, consistent with the benign clinical behavior of CPMT.
참고문헌 (20)
- McGinnis M, "Congenital peribronchial myofibroblastic tumor (so-called “congenital leiomyosarcoma”): a distinct neonatal lung lesion associated with nonimmune hydrops fetalis", Mod Pathol, 6, pp.487~492 (1993)
- Pettinato G, "Primary bronchopulmonary fibrosarcoma of childhood and adolescence: reassessment of a low-grade malignancy. Clinicopathologic study of five cases and review of the literature", Hum Pathol, 20, pp.463~471 (1989)
- Robb D, "A case of neonatal fibrosarcoma of lung", Br J Surg, 46, pp.173~174 (1958)
- Jimenez JF, "Primary bronchopulmonary leiomyosarcoma in childhood", Arch Pathol Lab Med, 110, pp.348~351 (1986)
- Guccion JG, "Bronchopulmonary leiomyosarcoma and fibrosarcoma: a study of 32 cases and review of the literature", Cancer, 30, pp.836~847 (1972)
- Khong TY, "Massive congenital mesenchymal malformation of the lung: another cause of non-immune hydrops", Histopathology, 16, pp.609~611 (1990)
- Warren JS, "Massive congenital mesenchymal malformation of the lung: a case report with ultrastructural study", Pediatr Pathol, 3, pp.321~328 (1985)
- Haller JO, "Congenital mesenchymal tumour of the lung", Br J Radiol, 50, pp.217~219 (1977)
- Jones CJ, "Unusual hamartoma of the lung in a newborn infant", Arch Pathol (Chic), 48, pp.150~154 (1949)
- Kuhnen C, "Congenital pulmonary fibrosarcoma: differential diagnosis of infantile pulmonary spindle cell tumors", Pathologe, 22, pp.151~156 (2001)
- An J, "Primary neoplasms of the lung in children and adolescents: 22 cases from a single institute", J Lung Cancer, 8, pp.103~110 (2009)
- Horikoshi T, "Fetal hydrops associated with congenital pulmonary myofibroblastic tumor", J Obstet Gynaecol Res, 31, pp.552~555 (2005)
- Reiss A, "Congenital pulmonary myofibroblastic tumor: pathology and prenatal sonographic appearance", Prenat Diagn, 25, pp.1064~1066 (2005)
- "Congenital pulmonary myofibroblastic tumor" (2008)[URL]
- de Noronha L, "Congenital peribronchial myofibroblastic tumor: a case report", Pediatr Dev Pathol, 13, pp.243~246 (2010)
- Huppmann AR, "Congenital peribronchial myofibroblastic tumor: comparison of fetal and postnatal morphology", Pediatr Dev Pathol, 14, pp.124~129 (2011)
- Alobeid B, "Congenital pulmonary myofibroblastic tumor: a case report with cytogenetic analysis and review of the literature", Am J Surg Pathol, 21, pp.610~614 (1997)
- Dishop MK, "Primary and metastatic lung tumors in the pediatric population: a review and 25-year experience at a large children’s hospital", Arch Pathol Lab Med, 132, pp.1079~1103 (2008)
- Savas C, "Acute respiratory distress due to fibrosarcoma of the carina in a child", Pediatr Pulmonol, 38, pp.355~357 (2004)
- Sahin D, "Congenital pulmonary fibrosarcoma in a newborn with hypoglycemia and respiratory distress: case report", Turk J Pediatr, 52, pp.325~329 (2010)