The New 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification of Lung Adenocarcinoma in Resected Specimens: Clinicopathologic Relevance and Emerging Issues
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Pathologists play an increasingly important role in personalized medicine for patients with lung cancer as a result of the newly recognized relationship between histologic classification and molecular change. In 2011, the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) proposed a new architectural classification for invasive lung adenocarcinomas to provide uniform terminology and diagnostic criteria. This review highlighted the evolution of the classification of lung adenocarcinomas in resected specimens with special respect to both histologic subtyping and invasion. Histologic subtyping of lung adenocarcinoma has been updated based on five major predominant patterns. New concepts of adenocarcinoma in situ and minimally invasive adenocarcinomas have been introduced to define the condition of patients who are expected to have excellent survival. Although the new IASLC/ATS/ERS classification has promising clinical relevance, significant clarification remains necessary for the definitions of subtyping and invasion. More precise definitions and subsequent better education on the interpretation of terminology will be helpful for future studies.
Abstract
Pathologists play an increasingly important role in personalized medicine for patients with lung cancer as a result of the newly recognized relationship between histologic classification and molecular change. In 2011, the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) proposed a new architectural classification for invasive lung adenocarcinomas to provide uniform terminology and diagnostic criteria. This review highlighted the evolution of the classification of lung adenocarcinomas in resected specimens with special respect to both histologic subtyping and invasion. Histologic subtyping of lung adenocarcinoma has been updated based on five major predominant patterns. New concepts of adenocarcinoma in situ and minimally invasive adenocarcinomas have been introduced to define the condition of patients who are expected to have excellent survival. Although the new IASLC/ATS/ERS classification has promising clinical relevance, significant clarification remains necessary for the definitions of subtyping and invasion. More precise definitions and subsequent better education on the interpretation of terminology will be helpful for future studies.
참고문헌 (43)
- World cancer report 2008, "Boyle P", International Agency for Research on Cancer, ~ (2008)
- Jemal A, "Cancer statistics, 2010", CA Cancer J Clin, 60, pp.277~300 (2010)
- Travis WD, "International Association for the Study of Lung Cancer", American Thoracic Society, J Thorac Oncol, pp.2011, 6[DOI]
- Travis WD, "World Health Organization classification of tumours: pathology and genetics of tumours of the lung, pleura, thymus and heart" (2004), IARC Press
- Yoshizawa A, "Impact of proposed IASLC", ATS, Mod Pathol, pp.2011, 24[DOI]
- Yoshizawa A, "Validation of the IASLC", ATS, J Thorac Oncol, pp.2013, 8[DOI]
- Warth A, "The novel histologic International Association for the Study of Lung Cancer", American Thoracic Society, J Clin Oncol, pp.2012, 30[DOI]
- Woo T, "Prognostic value of the IASLC", ATS, Pathol Int, pp.2012, 62[DOI]
- von der Thüsen JH, "Prognostic significance of predominant histologic pattern and nuclear grade in resected adenocarcinoma of the lung: potential parameters for a grading system", J Thorac Oncol, 8, pp.37~44 (2013)
- Yoshizawa A, "Validation of the IASLC", ATS, Mod Pathol, pp.2011, 24(Suppl 1)[DOI]
- Hwang I, "Histologic patterns and prognostic significance of invasive adenocarcinoma of lung: analyzed by 2010 IASLC", ATS, The 63rd Annual Fall Meeting of the Korean Society of Pathologists, pp.2011[DOI]
- Russell PA, "Does lung adenocarcinoma subtype predict patient survival?: A clinicopathologic study based on the new International Association for the Study of Lung Cancer", American Thoracic Society, J Thorac Oncol, pp.2011, 6[DOI]
- Thunnissen E, "Reproducibility of histopathological subtypes and invasion in pulmonary adenocarcinoma: an international interobserver study", Mod Pathol, 25, pp.1574~1583 (2012)
- Warth A, "Training increases concordance in classifying pulmonary adenocarcinomas according to the novel IASLC", ATS, Virchows Arch, pp.2012, 461[DOI]
- Warth A, "Interobserver variability in the application of the novel IASLC", ATS, Eur Respir J, pp.2012, 40[DOI]
- Wang C, "Complex acinar pattern: a distinct morphologic subtype and a poor prognostic indicator in primary lung adenocarcinoma", Mod Pathol, 26(Suppl 2), pp.469~ (2013)
- Wells JM, "Application of the new proposed adenocarcinoma classification: a reproducibility study", Mod Pathol, 26(Suppl 2), pp.469~ (2013)
- Joubert P, "Complex glands (cribriform and fused glands) are patterns of high grade adenocarcinoma in the lung", Mod Pathol, 26(Suppl 2), pp.456~ (2013)
- Travis WD, "New pathologic classification of lung cancer: relevance for clinical practice and clinical trials", J Clin Oncol, 31, pp.992~1001 (2013)
- Travis WD, "Diagnosis of lung adenocarcinoma in resected specimens: implications of the 2011 International Association for the Study of Lung Cancer", American Thoracic Society, Arch Pathol Lab Med, pp.2013, 137[DOI]
- Travis WD, "Histological typing of lung and pleural tumours" (1999), Springer
- Shim HS, "Histopathologic characteristics of lung adenocarcinomas with epidermal growth factor receptor mutations in the International Association for the Study of Lung Cancer", American Thoracic Society, Arch Pathol Lab Med, pp.2011, 135[DOI]
- Inamura K, "EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers", J Thorac Oncol, 3, pp.13~17 (2008)
- Yoshida A, "Frequent ALK rearrangement and TTF-1", p63 co-expression in lung adenocarcinoma with signet-ring cell component, 2011, pp.72, 309~315
- McLeer-Florin A, "Dual IHC and FISH testing for ALK gene rearrangement in lung adenocarcinomas in a routine practice: a French study", J Thorac Oncol, 7, pp.348~354 (2012)
- Paik JH, "Clinicopathologic implication of ALK rearrangement in surgically resected lung cancer: a proposal of diagnostic algorithm for ALK-rearranged adenocarcinoma", Lung Cancer, 76, pp.403~409 (2012)
- ". Augusta: United States & Canadian Academy of Pathology"[URL]
- Miyoshi T, "Early-stage lung adenocarcinomas with a micropapillary pattern, a distinct pathologic marker for a significantly poor prognosis", Am J Surg Pathol, 27, pp.101~109 (2003)
- Amin MB, "Micropapillary component in lung adenocarcinoma: a distinctive histologic feature with possible prognostic significance", Am J Surg Pathol, 26, pp.358~364 (2002)
- Sica G, "A grading system of lung adenocarcinomas based on histologic pattern is predictive of disease recurrence in stage I tumors", Am J Surg Pathol, 34, pp.1155~1162 (2010)
- De Oliveira Duarte Achcar R, "Micropapillary lung adenocarcinoma: EGFR, K-ras, and BRAF mutational profile", Am J Clin Pathol, 131, pp.694~700 (2009)
- Maeshima AM, "Histological scoring for small lung adenocarcinomas 2 cm or less in diameter: a reliable prognostic indicator", J Thorac Oncol, 5, pp.333~339 (2010)
- Nakazato Y, "Interobserver agreement in the nuclear grading of primary pulmonary adenocarcinoma", J Thorac Oncol, 8, pp.736~743 (2013)
- Noguchi M, "Small adenocarcinoma of the lung: histologic characteristics and prognosis", Cancer, 75, pp.2844~2852 (1995)
- Sakurai H, "Grade of stromal invasion in small adenocarcinoma of the lung: histopathological minimal invasion and prognosis", Am J Surg Pathol, 28, pp.198~206 (2004)
- Suzuki K, "Prognostic significance of the size of central fibrosis in peripheral adenocarcinoma of the lung", Ann Thorac Surg, 69, pp.893~897 (2000)
- Borczuk AC, "Invasive size is an independent predictor of survival in pulmonary adenocarcinoma", Am J Surg Pathol, 33, pp.462~469 (2009)
- Yim J, "Histologic features are important prognostic indicators in early stages lung adenocarcinomas", Mod Pathol, 20, pp.233~241 (2007)
- Terasaki H, "Lung adenocarcinoma with mixed bronchioloalveolar and invasive components: clinicopathological features, subclassification by extent of invasive foci, and immunohistochemical characterization", Am J Surg Pathol, 27, pp.937~951 (2003)
- 김철환, "Naked Cuticle Drosophila 1 Expression in Histologic Subtypes of Small Adenocarcinoma of the Lung", Journal of Pathology and Translational Medicine, 47(3), pp.211~218 (2013), 대한병리학회
- Xu L, "Adenocarcinomas with prominent lepidic spread: retrospective review applying new classification of the American Thoracic Society", Am J Surg Pathol, 36, pp.273~282 (2012)
- Anami Y, "Bronchioloalveolar carcinoma (lepidic growth) component is a more useful prognostic factor than lymph node metastasis", J Thorac Oncol, 4, pp.951~958 (2009)
- Xu L, "‘Bronchioloalveolar carcinoma’: is the term really dead? A critical review of a new classification system for pulmonary adenocarcinomas", Pathology, 44, pp.497~505 (2012)